The Role of Reactive Oxygen Species (ROS) in the Immune System and Health

Dear Colleagues, 

The dual role of reactive oxygen species (ROS) in human health is proposed in the literature. Under physiological conditions, endogenous levels of ROS are tightly controlled by various antioxidant systems; however, they form even more free radicals, resulting in oxidative stress, which can damage DNA, proteins, and lipid-based cellular membranes. Despite the danger posed by high levels of ROS, several studies implicated moderate levels as critical mediators of intracellular signaling pathways in various immune cells. ROS play an extensive role in T cells activation, apoptosis, and hypo-responsiveness; they have large impact through various molecular targets and sensitive pathways, including the regulation of protein phosphorylation, ion channels, and transcription factors. Additionally, a growing number of studies suggested the direct anti-tumor role of ROS in cancer conditions. Therefore, understanding the state of ROS-based molecular targets, which play a pivotal role in downstream regulation of various signaling pathways in immunity and health, is crucial in the potential management of a plethora of diseases. Here, we are pleased to invite you to participate in this Special Issue, entitled "The role of reactive oxygen species (ROS) in immune system and health", by presenting your most recent research on the physiological and pathological role of ROS in both immune and tumor conditions. Experimental papers, up-to-date review articles, and commentaries are all welcome.

Dr. Pawan Sirwan Faris
Dr. Roberto Berra-Romani
Guest Editors

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• reactive oxygen species
• Ca²⁺ signaling
• ion channels
• TRP channels
• immune system
• cancers
• molecular pathways