Stem Cell Therapy for Periodontal Disease

Dear Colleagues,

Periodontal disease is characterized by the chronic inflammation and reduction of tooth-supporting periodontal tissues. Periodontal regeneration using stem cells has been attracting attention for the past 20 years. While numerous animal and clinical studies have reported that stem-cell transplantation leads to the regeneration of periodontal tissues, little information is available on the mechanism of the regeneration. Additionally, some problems related to stem-cell transplantation have also come to light, such as the risk of tumorigenicity, limited cell sources, difficulty in controlling the behavior of transplanted cells, and cost of culturing transplanted cells. Therefore, periodontal regeneration using stem cells now requires ingenuity and new attempts to become a realistic treatment. These may include the search for new cell sources, the possibility of cell-free treatment, the validation of new regeneration mechanisms with stem cells, and the development of new materials for periodontal regeneration.

This Special Issue invites papers on the verification of new attempts to regenerate periodontal tissues and the clarification of regenerative mechanisms, inspired by stem-cell transplantation.

Dr. Kengo Iwasaki
Guest Editor

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