Hematopoietic and Lymphoid Tissue Involvement in Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 5683
Special Issue Editor
Interests: myelodysplastic syndrome; autoimmunity; lymphoma; Sjogren syndrome; leukemia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hematopoietic and lymphoid tissue involvement in autoimmune diseases is a well-established phenomenon. Hematologic abnormalities affecting one or more cell lines are common manifestations of autoimmune disease and can be reflective of disease activity. It has been suggested that there is an elevated risk of monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma in the presence of "any autoimmune disease". There is also a relationship between chronic immune dysregulation and lymphomagenesis, likely reflecting chronic immune activation and a resultant lymphoproliferative drive.
Abnormal immune regulation and persistent inflammation are hallmarks of autoimmune diseases. In addition to the production, maturation and activation of neutrophils, monocytes/macrophages and B cells, bone marrow plays a central role in regulating the immune response. It has been proposed that a defect of stem cells can ultimately cause functional changes in the immune cells derived and differentiated from them. Therefore, some researchers regard SLE as a “stem cell disorder”. Furthermore, there is strong evidence for the role of bone marrow and neutrophils in the pathogenesis of some autoimmune diseases, suggesting additional pathways for potential therapeutic modulation targeted at effector cells to minimize tissue injury.
Rheumatoid arthritis, Sjögren syndrome, systemic lupus erythematosus, celiac disease, and chronic thyroiditis have all been consistently linked to increased risks of lymphoma. The identification, validation, and use of lymphoma predictors in the setting of autoimmunity has been a matter of extensive research over the past few decades. Extensive efforts in the basic research field have revealed several novel biomarkers for lymphoma prediction, while the major cellular and molecular mechanisms of the evolutionary transition of B cells towards malignancy are under investigation.
In this Special Issue of the International Journal of Molecular Sciences, we seek to unveil the mysterious nature of the hematopoietic and lymphoid cells’ involvement in autoimmune diseases and exploit our continuously expanding knowledge to optimize therapeutics.
Dr. Michael Voulgarelis
Guest Editor
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Keywords
- autoimmune diseases
- lymphoma
- cytopenias
- bone marrow
- hematopoietic stem cell
- mesenchymal stem cells
- signaling pathways
- lymphomagenesis predictors
- immune deregulation
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