The Role of Tissue-Nonspecific Alkaline Phosphatase in Inflammation and Metabolic Syndrome 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 May 2022) | Viewed by 5952
Special Issue Editor
Interests: vascular calcification; pathological bone formation; tissue-nonspecific alkaline phosphatase; inflammation; mineralization
Special Issues, Collections and Topics in MDPI journals
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Dear Colleagues,
Tissue-nonspecific alkaline phosphatase (TNAP) is mainly known for its necessary function during bone mineralization, due to the dephosphorylation of the mineralization inhibitor inorganic pyrophosphate (PPi). TNAP is however a relatively ubiquitous enzyme expressed in liver, kidney or brain that is present in the blood, both as a soluble form and at the membrane of neutrophils. Serum TNAP activity is elevated in individuals with metabolic syndrome and is associated with their increased mortality risk. This association may result from the function of TNAP in inflammation, relying on the dephosphorylation of adenosine nucleotides and lipopolysaccharide. It may also rely on the stimulation of cardiovascular calcification resulting from PPi hydrolysis in the blood and/or cardiovascular tissues.
This Special Issue of IJMS aims to cover recent findings on the regulation of TNAP/ALPL during metabolic syndrome, on its inflammatory functions, and the consequences of its activation on cardiovascular mortality. Original research articles, comprehensive reviews, and short communications are all welcome.
Prof. Dr. David Magne
Guest Editor
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Keywords
- tissue-nonspecific alkaline phosphatase (TNAP)
- inflammation
- adenosine nucleotides
- lipopolysaccharide
- metabolic syndrome
- vascular calcification
- alkaline phosphatase
- ALPL
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