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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Study on Organellar Genomes of Vascular Plants submission deadline 30 Nov 2024 | Viewed by 98 | Submission Open
Keywords: mitochondrial DNA (mtDNA); chloroplast DNA (cpDNA); plant evolution; plant organellar genome; genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions (2nd Edition)
edited by
submission deadline 30 Nov 2024 | Viewed by 96 | Submission Open
Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety
(This special issue belongs to the Section Molecular Neurobiology)
Preclinical Models for Novel Drug Combination in Advanced Ovarian Cancer
edited by
submission deadline 30 Nov 2024 | Viewed by 95 | Submission Open
Keywords: ovarian cancer; drug treatment; clinical trials; PARP inhibitors; 3D cell models
(This special issue belongs to the Section Molecular Oncology)
Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases
edited by
submission deadline 30 Nov 2024 | Viewed by 95 | Submission Open
Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase
(This special issue belongs to the Section Molecular Biology)
Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases, 3rd Edition
edited by
submission deadline 30 Nov 2024 | Viewed by 91 | Submission Open
Keywords: cardiovascular diseases; metabolic diseases; cellular and molecular mechanisms
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Insights into Bioactive Compounds from Microalgae submission deadline 30 Nov 2024 | Viewed by 89 | Submission Open
Keywords: microalgae; biotechnology; cyanobacteria; chlamydomonas; separation and purification; bioactive secondary metabolites; biomass
(This special issue belongs to the Section Bioactives and Nutraceuticals)
G-protein Coupled Receptors
edited by
submission deadline 30 Nov 2024 | Viewed by 87 | Submission Open
Keywords: G-protein-coupled receptors; GPCR; therapeutic drugs
(This special issue belongs to the Section Biochemistry)
Advances in Plant Saline-Alkali Stress
edited by Zhengwei Liang
submission deadline 30 Nov 2024 | Viewed by 87 | Submission Open
Keywords: saline-alkali stress; plant physiology changes; stress tolerance; stress signaling pathways; genetic regulation; plant hormones
(This special issue belongs to the Section Molecular Plant Sciences)
Innovations in Seizure Management: Exploring New Antiseizure Medications and Targeted Therapies
edited by Antonio Gennaro Nicotera and Gabriella Di Rosa
submission deadline 30 Nov 2024 | Viewed by 78 | Submission Open
Keywords: antiseizure medications; targeted therapies; epilepsy; monogenic epilepsies; new antiseizures medications; developmental and epileptic encephalopathies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Enzymes in Metabolic Processes
edited by
submission deadline 1 Dec 2024 | 2 articles | Viewed by 2397 | Submission Open
Keywords: enzyme; metabolism; glycolysis; mitochondria; kinase; cell growth; carcinogenesis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Biology of Cancer—Implications for Diagnosis and Treatment: 2nd Edition submission deadline 5 Dec 2024 | 15 articles | Viewed by 24889 | Submission Open
Keywords: genomics; epigenetics; translational research; oncology precision medicine
(This special issue belongs to the Section Molecular Oncology)
Tissue Engineering and Cell Therapy: Recent Progress
edited by
submission deadline 10 Dec 2024 | 3 articles | Viewed by 7571 | Submission Open
Keywords: biomaterials and cell sources for tissue engineering and cell therapy; tissue engineering of substitutes in vitro; functional testing of tissues reconstructed in vitro; extracellular matrix; mechanical characteristics; biological and histological characterization; translational research
(This special issue belongs to the Section Biochemistry)
A Molecular Perspective on Reproductive Health, 2nd Edition submission deadline 10 Dec 2024 | 1 articles | Viewed by 627 | Submission Open
Keywords: reproductive function; molecular bases; male; female; reproductive pathology; reproductive physiology
(This special issue belongs to the Section Biochemistry)
Physiological and Pathological Hypoxia: The Battle between the Protective and Deleterious Effects of Oxygen Deprivation
edited by , , and Giacomo Strapazzon
submission deadline 10 Dec 2024 | Viewed by 143 | Submission Open
Keywords: physiological hypoxia; pathological hypoxia; hypoxia; signalling pathway; inflammation; oxygen transport
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Endocannabinoid Receptors in Human Health and Disease, 2nd Edition submission deadline 10 Dec 2024 | Viewed by 92 | Submission Open
Keywords: endocannaibnoid; cannabinoid; receptors; GPCR; TRP channels; nuclear receptors; PPARS; physiology; pathophysiology
(This special issue belongs to the Section Molecular Pharmacology)
Fungal Pathogen-Host Interactions
edited by Patricia Albuquerque
submission deadline 10 Dec 2024 | Viewed by 84 | Submission Open
Keywords: medical mycology; host– microbe interactions; macrophages; dendritic cells; neutrophils
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research in Aggressive Behavior submission deadline 13 Dec 2024 | Viewed by 207 | Submission Open
Keywords: aggressive behaviour; molecular mechanisms; agitation; mental disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pathogenesis and Treatment of Pregnancy Complications
edited by Radzisław Mierzyński and
submission deadline 15 Dec 2024 | 9 articles | Viewed by 9236 | Submission Open
Keywords: preterm delivery; intraamniotic infection; preeclampsia; hypertension; metabolic syndrome; maternal health; prematurity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Research on Neurotransmitters
edited by , and Jing-Ning Zhu
submission deadline 15 Dec 2024 | 3 articles | Viewed by 4593 | Submission Open
Keywords: neurotransmitter; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis
(This special issue belongs to the Section Molecular Neurobiology)
Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers, 3rd Edition
edited by , and Enikö Kallay
submission deadline 15 Dec 2024 | 4 articles | Viewed by 4066 | Submission Open
Keywords: drug design and discovery; antimicrobial drugs; antiviral drugs; antibiotics; cancer prevention and treatment; molecular modeling; molecular mechanisms; crystallography; preclinical studies; pharmacokinetics; pharmacodynamics; pharmacognosy; drug-protein interactions nuclear receptors; receptor agonists and antagonists; stem cells; activity profiling; vaccines; markers; and diagnostics; drug carriers; dosage form; anti-crystal engineering; nanoparticles; dissolution testing
(This special issue belongs to the Section Molecular Pharmacology)
Synthesis and Biological Activity of Heterocyclic Compounds
edited by
submission deadline 15 Dec 2024 | 2 articles | Viewed by 3515 | Submission Open
Keywords: heteroarenes; organic synthesis; new methodologies; functionalizations; drugs; enzyme inhibition; biological activity
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Signaling Pathways in Neurodegenerative Disorders
edited by
submission deadline 15 Dec 2024 | 2 articles | Viewed by 3493 | Submission Open
Keywords: Alzheimer's and Huntington's disease; human neurodegenerative diseases; gamma-aminobutyric acid (GABA) and glutamate signalling; estrogen signalling; neurotrophin signalling
(This special issue belongs to the Section Molecular Neurobiology)
Unraveling Sugar Signaling: Insights into Plant Stress Responses
edited by
submission deadline 15 Dec 2024 | 1 articles | Viewed by 1137 | Submission Open
Keywords: sugar signaling; glucose signaling; sucrose signaling; signal transduction pathways; plant response to stress; biotic stress; abiotic stress; plant physiology
(This special issue belongs to the Section Molecular Plant Sciences)
New Advances in Medical Microbiology
edited by
submission deadline 15 Dec 2024 | 1 articles | Viewed by 872 | Submission Open
Keywords: clinical microbiology; clinical virology; SARS-CoV-2; HPV; sexually transmitted infections; respiratory viruses; emerging pathogens; opportunistic infections
(This special issue belongs to the Section Molecular Microbiology)
Microbial Pigments: Diversity, Production and Applications
edited by
submission deadline 15 Dec 2024 | Viewed by 747 | Submission Open
Keywords: astaxanthin; fungal pigments; melanin; phenazine; synthetic biology; bacterial pigment production; antioxidants; UV-protection; prodigiosin
(This special issue belongs to the Section Molecular Microbiology)
Bilirubin: Health Challenges and Opportunities
edited by
submission deadline 15 Dec 2024 | Viewed by 331 | Submission Open
Keywords: bilirubin; biomedical science; neurobiology; Parkinson’ s disease; brain neuroprotection
(This special issue belongs to the Section Molecular Biology)
Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease submission deadline 15 Dec 2024 | Viewed by 259 | Submission Open
Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning
(This special issue belongs to the Section Molecular Informatics)
Novel Treatment Strategies for Head and Neck Cancer
edited by
submission deadline 15 Dec 2024 | Viewed by 143 | Submission Open
Keywords: head and neck cancer; drug resistance; cancer initiation; biomarker
(This special issue belongs to the Section Molecular Oncology)
Microbiome Modulation through Probiotics: Molecular Insights and Therapeutic Applications
edited by
submission deadline 15 Dec 2024 | Viewed by 134 | Submission Open
Keywords: live bacterial cells; prebiotic agents; synbiotic formulations; probiotic formulations; microbial dysbiosis; inflammation; oxidative stress; host– microbe interactions
(This special issue belongs to the Section Molecular Microbiology)
New Research Insights in Cystic Fibrosis and CFTR-Related Diseases
edited by Judith A. Coppinger
submission deadline 15 Dec 2024 | Viewed by 118 | Submission Open
Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine
edited by
submission deadline 15 Dec 2024 | Viewed by 108 | Submission Open
Keywords: polymer-based nanoparticles; lipid nanoparticles; PLGA and chitosan nano/microparticles for gene therapy; targeted drug delivery; nucleic acid-loaded nanoparticles; siRNA nanoparticles; nanoparticle-mediated mirna delivery; nanoparticles in cancer therapy; nanoparticles in vaccine design; nanoparticle-mediated gene therapy
(This special issue belongs to the Section Molecular Pharmacology)
Coronavirus Disease (COVID-19): Pathophysiology 5.0 submission deadline 20 Dec 2024 | 9 articles | Viewed by 33936 | Submission Open
Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights in Natural Bioactive Compounds: 3rd Edition submission deadline 20 Dec 2024 | 15 articles | Viewed by 20666 | Submission Open
Keywords: inflammation; cytokines; ROS; oxidative stress; natural products; flavonoids; cannabinoids
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Research of Nanomaterials in Molecular Science
edited by
submission deadline 20 Dec 2024 | 11 articles | Viewed by 18228 | Submission Open
Keywords: nanomaterials; medical research; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy
(This special issue belongs to the Section Molecular Nanoscience)
Trends and Prospects of Flow Cytometry in Cell and Molecular Biology submission deadline 20 Dec 2024 | 10 articles | Viewed by 15637 | Submission Open
Keywords: biochemistry; molecular biology; cell function; cell metabolism; new cytometries; new applications; new methods; microbiology
(This special issue belongs to the Section Molecular Biology)
Molecular Physiological and Pathological Progression of Neurological Diseases
edited by
submission deadline 20 Dec 2024 | 11 articles | Viewed by 15442 | Submission Open
Keywords: neurological diseases; molecular pathways; spinal cord lesion; cognitive disabilities; epilepsy; stroke; motorneuron diseases; glioblastoma; autism; stem cells; organoids
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Responses to Heat Stress
edited by and
submission deadline 20 Dec 2024 | 7 articles | Viewed by 15408 | Submission Open
Keywords: high temperatures; thermotolerance; stress memory; temperature sensing; signal transduction; protein homeostasis; genomics; transcriptomics; proteomics; metabolomics; epigenetics; microrna; omics; warming; heat-stress priming; heat memory; alternative splicing; heat adaptation; heat tolerance; oxidative stress; photosynthesis; reactive oxygen species; signaling molecules; heat shock
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Estrogen and Its Receptors in the Development and Therapy of Cancer submission deadline 20 Dec 2024 | 7 articles | Viewed by 14889 | Submission Open
Keywords: estrogen; estrogen receptor; breast cancer; anticancer therapy; cancer development; cancer progression; metastasis
(This special issue belongs to the Section Molecular Oncology)
Biophysical Characterization and Molecular Engineering of Multidomain Proteins 3.0 submission deadline 20 Dec 2024 | 7 articles | Viewed by 14492 | Submission Open
(This special issue belongs to the Section Molecular Biophysics)
High-Density Lipoproteins in Health and Disease
edited by
submission deadline 20 Dec 2024 | 6 articles | Viewed by 14246 | Submission Open
Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy
(This special issue belongs to the Section Molecular Biology)
New Players in the Research of Oxidative Stress and Cancer submission deadline 20 Dec 2024 | 6 articles | Viewed by 14175 | Submission Open
Keywords: cancer; oxidative stress; biomarkes; redox signaling pathway; therapy resistance
(This special issue belongs to the Section Biochemistry)
Therapeutic Potential of Antioxidants in the Prevention of Human Diseases
edited by
submission deadline 20 Dec 2024 | 7 articles | Viewed by 13730 | Submission Open
Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Development of Dopaminergic Neurons 3.0
edited by
submission deadline 20 Dec 2024 | 6 articles | Viewed by 13669 | Submission Open
Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell
(This special issue belongs to the Section Molecular Neurobiology)
From Nanotechnology to Nanomedicine: Past, Present and Future
edited by
submission deadline 20 Dec 2024 | 4 articles | Viewed by 13657 | Submission Open
Keywords: natural and synthetic polymers; composite materials; biomimetics; bionanotechnology; side products of biodegradation
(This special issue belongs to the Section Molecular Nanoscience)
Drug Resistance in Cancer: Molecular Mechanisms and Tackling Strategies, 2nd Edition
edited by
submission deadline 20 Dec 2024 | 8 articles | Viewed by 13598 | Submission Open
Keywords: apoptosis; cancer; clinical trials; chemotherapy; drug metabolism; drug resistance; drug delivery; heterogeneity; immunotherapy; microenvironment
(This special issue belongs to the Section Molecular Pharmacology)
Cellular Crosstalk in the Tumor Microenvironment submission deadline 20 Dec 2024 | 7 articles | Viewed by 13421 | Submission Open
Keywords: cancer; metastasis; inflammation; cancer-associated fibroblasts; biomarkers; multiplex imaging; in vitro models; animal models; immunotherapy
(This special issue belongs to the Section Biochemistry)
Natural Compounds and Oxidative Stress
edited by
submission deadline 20 Dec 2024 | 6 articles | Viewed by 13293 | Submission Open
Keywords: oxidative stress; natural compounds; bioactive compounds; chronic diseases; therapeutic agents
(This special issue belongs to the Section Bioactives and Nutraceuticals)
G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities
edited by J. Adolfo García-Sáinz
submission deadline 20 Dec 2024 | 9 articles | Viewed by 13246 | Submission Open
Keywords: GPCR; cell signaling; small molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode
(This special issue belongs to the Section Molecular Pharmacology)
The Promising Future of CAR-Based Therapies: A Matter of Molecular Details submission deadline 20 Dec 2024 | 5 articles | Viewed by 13235 | Submission Open
Keywords: CAR; genetic engineering; T; NK; CIK; ATMP; GMP manufacturing; off-the-shelf; TME; cell exhaustion
(This special issue belongs to the Section Molecular Immunology)
Peptides as Biochemical Tools and Modulators of Biological Activity
edited by
submission deadline 20 Dec 2024 | 4 articles | Viewed by 12998 | Submission Open
Keywords: peptides; phage display; stem cells; mesenchymal stromal cells; cancer; leukemia; tumor targeting; drug delivery
(This special issue belongs to the Section Molecular Biology)
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