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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research Progress of Optoelectronic Materials and Devices
edited by Moon Jong Han
submission deadline 20 Feb 2026 | Viewed by 369 | Submission Open
Keywords: semiconductors; multifunctionalities; optoelectronics; structure-driven properties; thin films; polymers
(This special issue belongs to the Section Materials Science)
Fungal Genetics and Functional Genomics Research
edited by and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 366 | Submission Open
Keywords: enzymes; fungal genetics; fungi; gene editing; regulation; secondary metabolites; synthetic biology; transcription
(This special issue belongs to the Section Molecular Genetics and Genomics)
Osteoporosis: From Molecular Research to Novel Therapies
edited by and Anastasia Xourafa
submission deadline 20 Feb 2026 | Viewed by 364 | Submission Open
Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis and Transformations of Bioactive Cyclic Imides
edited by
submission deadline 20 Feb 2026 | Viewed by 361 | Submission Open
Keywords: PROTAC; phthalimides; maleimides; cyclic imides; targeted protein degradation; protein labeling; antibody–drug conjugates; drug design and synthesis; drug conjugation
(This special issue belongs to the Section Biochemistry)
Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment
edited by
submission deadline 20 Feb 2026 | Viewed by 355 | Submission Open
Keywords: alcohol; addiction; abuse; inflammation; neurodegeneration; cognition; neuroimmunology; oxidative stress
(This special issue belongs to the Section Molecular Biology)
Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy
edited by
submission deadline 20 Feb 2026 | Viewed by 342 | Submission Open
Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake
(This special issue belongs to the Section Molecular Nanoscience)
The Neuro and Immune Mechanisms Behind Cannabinoids Effects
edited by
submission deadline 20 Feb 2026 | Viewed by 340 | Submission Open
Keywords: cannabinoids; neuroinflammation; endocannabinoid system (ECS); non-cannabinoid receptors; immune modulation; synaptic plasticity
(This special issue belongs to the Section Biochemistry)
The Translation Process, Molecular Mechanism, and Recognition Methods of Post-Translational Modifications of Proteins
edited by
submission deadline 20 Feb 2026 | Viewed by 334 | Submission Open
Keywords: DNA replication; repair; and transcription; post-translational modifications; chromatin; acetylation; methylation; phosphorylation; ubiquitination and ubiquitin-like modifiers; histone modifications
(This special issue belongs to the Section Molecular Informatics)
Artificial Intelligence in Nano- and Bio-Technology Systems: Focus on Molecular Research
edited by
submission deadline 20 Feb 2026 | Viewed by 330 | Submission Open
Keywords: artificial intelligence; nanotechnology; biotechnology; medicine; energy systems; blockchain
(This special issue belongs to the Section Molecular Nanoscience)
Recent Advances in Natural Compounds: Biosynthesis and Application
edited by , Marya Raji and El Habib Ait Addi
submission deadline 20 Feb 2026 | Viewed by 328 | Submission Open
Keywords: natural compounds; chemical composition; biological activities; biosynthesis; bioconversion; application
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Diverse Biomolecular Probes in the Development of Single-Molecule Biosensors submission deadline 20 Feb 2026 | Viewed by 322 | Submission Open
Keywords: biomolecular probes; single-molecule method; biosensors; diseases diagnosis; biomarkers; nanotechnology
(This special issue belongs to the Section Materials Science)
The Roles of Oxidative Stress in Metabolic Syndrome submission deadline 20 Feb 2026 | Viewed by 322 | Submission Open
Keywords: oxidative stress; metabolic syndrome; inflammation; antioxidants; human chronic diseases; cardiometabolic diseases; nutrition; lifestyle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurodegenerative Disorders: Advances in Mechanisms, Models, and Therapeutics
edited by Craig Bennett
submission deadline 20 Feb 2026 | Viewed by 316 | Submission Open
Keywords: TDP-43; C9orf72; dipeptide repeat; proteotoxicity; cryptic exon exclusion; L-BMAA
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Molecular Biology of Ovarian Cancer
edited by and Cinzia Garofalo
submission deadline 20 Feb 2026 | Viewed by 308 | Submission Open
Keywords: ovarian cancer; signaling pathways; transcription factors; cancer metabolism; chemoresistance; tumor microenvironment; ovarian cancer stem cells; cancer therapies
(This special issue belongs to the Section Molecular Oncology)
PD-L1 – PD1 Signaling Axis: From Mechanism to Therapeutics submission deadline 20 Feb 2026 | Viewed by 302 | Submission Open
Keywords: PD-L1/PD1 immune checkpoints; cancer; mechnistic insights and resistances; adaptive immune regulation; therapeutic strategies
(This special issue belongs to the Section Molecular Oncology)
Advanced Research on Nanosensors for Molecular Sensing Applications
edited by
submission deadline 20 Feb 2026 | Viewed by 294 | Submission Open
Keywords: nanostructure; microfabrication; nanoparticles; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; molecular recognition; biosensor; sensing mechanism; nanowires; affinity sensor
(This special issue belongs to the Section Molecular Nanoscience)
Gene Mining and Germplasm Innovation for the Important Traits in Rice (Second Edition)
edited by and
submission deadline 20 Feb 2026 | Viewed by 293 | Submission Open
Keywords: rice; gene mining; important traits; molecular design; gene editing; germplasm innovation
(This special issue belongs to the Section Molecular Plant Sciences)
Anticancer Agents of the Future: From Specific Molecular Targets to Individual Patient Profile
edited by
submission deadline 20 Feb 2026 | Viewed by 289 | Submission Open
Keywords: anticancer drug research; selective antitumor therapy; tumor cell molecular targets; tumor healthy cells selectivity; cancer cell metabolism; anticancer drug delivery; individual anticancer therapy; dual targeting anticancer therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Targets in Alzheimer’s Disease: From Mechanisms to Therapeutic Strategies submission deadline 20 Feb 2026 | Viewed by 286 | Submission Open
Keywords: amyloid beta; neurodegeneration; neuroinflammation; microglia; mitochondrial dysfucntion; oxidative stress; molecular pathway; biomarkers of AD
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms, Therapeutic Challenges, and Pathogenesis of Complications in Liver Cirrhosis
edited by
submission deadline 20 Feb 2026 | Viewed by 286 | Submission Open
Keywords: muscle spasm; pruritus; sleep disturbances; sarcopenia; osteoporosis; infection; hepatopulmonary syndrome; hepatorenal syndrome; cirrhotic cardiomyopathy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Herpesviruses (2nd Edition)
edited by
submission deadline 20 Feb 2026 | Viewed by 283 | Submission Open
Keywords: α -herpesviridae; β -herpesviridae; γ -herpesviridae; herpesviruses associated diseases
(This special issue belongs to the Section Molecular Microbiology)
Purine Signaling as a Therapeutic Target in Human Diseases
edited by
submission deadline 20 Feb 2026 | Viewed by 279 | Submission Open
Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development
edited by Gabriela Verónica Salamone
submission deadline 20 Feb 2026 | 1 articles | Viewed by 273 | Submission Open
Keywords: gliomas tumor microenvironment immune
(This special issue belongs to the Section Molecular Oncology)
Advances in Ferrocene-Based Molecular Research: Synthesis, Properties, and Applications submission deadline 20 Feb 2026 | Viewed by 272 | Submission Open
Keywords: ferrocene; organometallic chemistry; bioorganometallic chemistry; ferrocene derivatives; synthesis; applications; bioconjugates
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Autophagy and Viral Infections: The Era of New Therapeutical Strategies
edited by
submission deadline 20 Feb 2026 | Viewed by 272 | Submission Open
Keywords: autophagy; macroautophagy system; virus; viral infection; influenzae virus
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Mycorrhizal Research for Promoting Plant Growth Under Abiotic Stress submission deadline 20 Feb 2026 | Viewed by 271 | Submission Open
Keywords: plant-mycorrhizal symbiosis; climate changes; environmental stress; plant stress-tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Locus Coeruleus in Regulating Sudden Cortical States and Preventing Neurodegeneration
edited by
submission deadline 20 Feb 2026 | Viewed by 269 | Submission Open
Keywords: reticular formation; norepinephrine; neuroplasticity; neuroprotection; neurodegenerations; adrenergic receptors; dementia; parkinson's disease; autism; affective disorders; addiction; psychostimulants
(This special issue belongs to the Section Molecular Neurobiology)
Drug Development and Discovery for Alzheimer's Disease
edited by Martha Cecilia Rosales-Hernández
submission deadline 20 Feb 2026 | Viewed by 266 | Submission Open
Keywords: Alzheimer's disease; drug design; repurposed molecules; therapeutic targets; amyloid-β ; β -secretase; acetylcholin-esterase; in silico studies; oxidative stress; chemical synthesis
(This special issue belongs to the Section Molecular Neurobiology)
Pain: From Bench to Bedside
edited by and Robert J. Yong
submission deadline 20 Feb 2026 | Viewed by 264 | Submission Open
Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research     TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Application of Large Language Model and Agents in Molecular Medicine and Molecular Biology
edited by and Hao Lv
submission deadline 20 Feb 2026 | Viewed by 254 | Submission Open
Keywords: large language models; artificial intelligence; agents; biological data; medical data
(This special issue belongs to the Section Molecular Informatics)
New Advances in Natural Product Synthesis and Emerging Biotechnology Applications
edited by Katarzyna Kotwica-Mojzych
submission deadline 20 Feb 2026 | Viewed by 249 | Submission Open
Keywords: natural compounds; natural product synthesis; chemical analysis; molecular technologies; biotechnology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Acute Myeloid Leukemia: From Molecular Insights to Therapeutic Innovations
edited by
submission deadline 20 Feb 2026 | Viewed by 239 | Submission Open
Keywords: acute myeloid leukemia; AML; epigenetic Mechanisms; genetics; epigenetic regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges submission deadline 20 Feb 2026 | Viewed by 237 | Submission Open
Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy
(This special issue belongs to the Section Materials Science)
Roles of Exosomes in Health and Disease
edited by
submission deadline 20 Feb 2026 | Viewed by 229 | Submission Open
Keywords: exosomes; extracellular vesicles; intercellular communication; diagnostics; therapeutics; disease; biomarkers; cellular biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms
edited by and
submission deadline 20 Feb 2026 | Viewed by 227 | Submission Open
Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Development Biology of Immune Cells
edited by Jacek Z. Kubiak
submission deadline 20 Feb 2026 | Viewed by 226 | Submission Open
Keywords: immune cell development; macrophages; monocytes; B-cells; T-cells; dendritic cells; NK cells
(This special issue belongs to the Section Molecular Immunology)
Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment submission deadline 20 Feb 2026 | Viewed by 221 | Submission Open
Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment
(This special issue belongs to the Section Molecular Oncology)
Nanotechnology for Food Science—Innovations and Sustainable Solutions
edited by
submission deadline 20 Feb 2026 | Viewed by 221 | Submission Open
Keywords: nanotechnology; nanomaterial synthesis; food safety; food science; nano-engineered food additives; nano-sensors
(This special issue belongs to the Section Molecular Nanoscience)
The Role of the Gut and Oral Microbiota in Neurodevelopment: Molecular Biological Insights
edited by Ioannis Alexandros Charitos
submission deadline 20 Feb 2026 | Viewed by 215 | Submission Open
Keywords: neuroscience; central nervous system; peripheral nervous system; human microbiota; metabolome; gut– oral-microbiota– brain axis; neurodevelopment disorders; cognitive modulation; neurodegenerative diseases; psychobiotics
(This special issue belongs to the Section Molecular Microbiology)
New Advances in Plant Genetic Research
edited by
submission deadline 20 Feb 2026 | Viewed by 211 | Submission Open
Keywords: plant generative genomics; plant– microbe interaction gene-editing; single-cell omics in plants; plant non-coding RNAs; AI in plant science
(This special issue belongs to the Section Molecular Plant Sciences)
Electron or Ion Transport in Electrochemistry
edited by Simone Sanna
submission deadline 20 Feb 2026 | Viewed by 210 | Submission Open
Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Advances of Layered Double Hydroxides (LDH) for Corrosion Protection
edited by
submission deadline 20 Feb 2026 | Viewed by 210 | Submission Open
Keywords: layered double hydroxide (LDHs); corrosion resistance; coatings; corrosion products
(This special issue belongs to the Section Materials Science)
From Pathogenic Mechanisms to Therapy in Retinal Diseases submission deadline 20 Feb 2026 | Viewed by 209 | Submission Open
Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Development and Applications of Biodegradable and Bioactive Materials submission deadline 20 Feb 2026 | Viewed by 209 | Submission Open
Keywords: biopolymers; bioplastics; sustainability; food packaging; medicine and cosmetic; bioactive compounds; wound healing; active and intelligent packaging
(This special issue belongs to the Section Materials Science)
Advanced Research in Immune Cell Therapy
edited by
submission deadline 20 Feb 2026 | Viewed by 207 | Submission Open
Keywords: molecular biology; bioinformatics; proteomics; molecular mechanisms; genomics
(This special issue belongs to the Section Molecular Immunology)
NURR1 Biology in Neurological Disorders and Other Diseases submission deadline 20 Feb 2026 | Viewed by 204 | Submission Open
Keywords: NURR1; regulation; chronic diseases; inflammation; neurodegenerative diseases; neurological diseases; cancer; inflammatory diseases
(This special issue belongs to the Section Molecular Biology)
Theranostic Application of Reactive Oxygen Species-Sensitive Nanocarriers
edited by
submission deadline 20 Feb 2026 | Viewed by 201 | Submission Open
Keywords: ROS generation; ROS detection; ROS-sensitive nanoparticles; Photodynamic therapy (PDT)
(This special issue belongs to the Section Molecular Nanoscience)
Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets
edited by Uchenna John Unachukwu
submission deadline 20 Feb 2026 | Viewed by 200 | Submission Open
Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics
(This special issue belongs to the Section Molecular Biology)
Age-Dependence of Neuroimmune Reactions
edited by
submission deadline 20 Feb 2026 | Viewed by 194 | Submission Open
Keywords: age; neuroimmune dynamics; neuroimmune interaction; immune system; the central nervous system; age-related neuroinflammation; neurodegenerative diseases
(This special issue belongs to the Section Molecular Immunology)
Nutrition from Cereal Foods: Molecular Insights into Nutrition, Metabolism and Health Regulation
edited by Genyi Zhang
submission deadline 20 Feb 2026 | Viewed by 192 | Submission Open
Keywords: molecular breeding; cereal crops; bioactive compounds; metabolic syndrome; inflammation; gut health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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