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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Perspectives on Virus–Host Interactions
edited by
submission deadline 20 Nov 2025 | 6 articles | Viewed by 5887 | Submission Open
Keywords: viral manipulation of host metabolics; virus– host interactions; host– pathogen co-evolution; susceptibility and resistance to viral infection; novel antiviral strategies
(This special issue belongs to the Section Molecular Microbiology)
Recent Progress in Molecular Mechanisms of Sperm Metabolism and Development
edited by Karl Kerns
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5861 | Submission Open
Keywords: sperm development  ; germ cell proliferation  ; sperm cell metabolism  ; seminal fluid biochemical composition  ; spermatogenesis  ; epididymal maturation  ; sperm capacitation  ; oocyte activation  
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms and New Markers of Cancer
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 5847 | Submission Open
Keywords: molecular pathology; molecular mechanisms; immunotherapy; cancer; oncology; pathology; biomarkers
(This special issue belongs to the Section Molecular Oncology)
The Role of miRNA in Human Diseases
edited by and Seeun Ha
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5808 | Submission Open
Keywords: miRNA; diabetes; obesity; fatty liver disease; gastrointestinal disease
(This special issue belongs to the Section Molecular Genetics and Genomics)
Microbiota and Cancer: 4th Edition submission deadline 20 Nov 2025 | 2 articles | Viewed by 5805 | Submission Open
Keywords: gut microbiota; cancer; hematopoietic stem cell transplantation; human microbiome; immune system; colon cancer; carcinogenesis; nutrition; short-chain fatty acids; metagenomic; dysbiosis
(This special issue belongs to the Section Molecular Oncology)
The Application of Machine Learning to Molecular Dynamics Simulations
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 5803 | Submission Open
Keywords: molecular dynamics simulations; machine learning; AI in drug discovery; pharmacokinetics prediction; protein folding simulations; toxicity prediction using ML; free energy calculations; virtual screening; protein– ligand interactions; protein– protein interactions
(This special issue belongs to the Section Molecular Informatics)
The Molecular Basis of Plant–Microbe Interactions submission deadline 20 Nov 2025 | 3 articles | Viewed by 5657 | Submission Open
Keywords: plant immune and defense responses; microbe and microbiome function; microbial biodiversity; abiotic and biotic stress mitigation; gene regulatory mechanisms; plant hormones in plant– microbe interactions; molecular mechanisms of plant growth and microbe interactions; chemical communication in plant– microbe interactions; microbe effects on fruit quality; OMICs approaches (metagenomics; metatranscriptomics; epigenomics; transcriptomics; metabolomics); bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Bioactive Compounds from Agro-Industrial Waste Biomass submission deadline 20 Nov 2025 | 2 articles | Viewed by 5656 | Submission Open
Keywords: by-product; biocompound; bioactivity; component analysis; in vitro/in vivo experiments; circular economy; sustainability; biomass residues valorization
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Emerging Therapies in Neurovascular Disease
edited by Leonidas D. Panos
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5494 | Submission Open
Keywords: neurovascular diseases; blood– brain barrier; endothelial dysfunction; cellular signaling; gene therapy
(This special issue belongs to the Section Molecular Neurobiology)
Basic Mechanisms of Physiological and Pathological Autoimmunity and Their Role in the Development of Autoimmune Diseases
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5435 | Submission Open
Keywords: physiologic autoimmunity; autoimmune diseases; natural immune system; pathologic autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Advancements in Alzheimer’s Disease Treatment: Exploring Novel Approaches and Strategies
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 5338 | Submission Open
Keywords: Alzheimer’ s disease; bioinformatics; novel compounds; in vitro; in vivo; clinical study; Alzheimer’ s disease models
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Molecular Pathophysiology of Diabetes, Hypertension and Cardiovascular Diseases
edited by Alessandro Durante
submission deadline 20 Nov 2025 | 1 articles | Viewed by 5196 | Submission Open
Keywords: diabetes; hypertension; cardiology; cardiovascular diseases; coronary artery diseases; athero-sclerosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antioxidant and Antibacterial Properties of Phytochemicals
edited by and Vytaute Starkute
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5192 | Submission Open
Keywords: phytochemicals; natural preservatives; antioxidants; antibacterial properties; food; cosmetics; pharmaceuticals; animal feed
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Catalytic Materials (Second Edition)
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5184 | Submission Open
Keywords: synthetic routes; nanomaterials; catalysis; sustainability; biomass; biofuel; photocatalysis; fine chemistry
(This special issue belongs to the Section Materials Science)
Endometriosis and Infertility
edited by Ludwig Kiesel
submission deadline 20 Nov 2025 | 2 articles | Viewed by 5145 | Submission Open
Keywords: endometriosis; infertility; subfertility; physiological mechanisms; treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Organic Synthesis in Drug Discovery submission deadline 20 Nov 2025 | 3 articles | Viewed by 5118 | Submission Open
Keywords: organic synthesis; drug design; heterocyclic chemistry; functionalization
(This special issue belongs to the Section Molecular Pharmacology)
Oral Cancer: Update on Molecular Pathology, Mechanisms and Treatments
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 5095 | Submission Open
Keywords: oral cancer; mechanisms of incidence and development of oral cancer; metastasis; diagnosis; biomarkers; treatments (active ingredients; medicines; biomedicines; and gene therapy)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products and Synthetic Derivatives in Cancer and Inflammatory Diseases
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 5053 | Submission Open
Keywords: angiogenesis inhibition; caspase activation; cytokine modulation; drug discovery; ethnopharmacology; plant metabolites; marine natural products; molecular docking; oxidative stress; tumor microenvironment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Cognitive Dysfunction from COVID-19 Infection and Other Respiratory Viruses
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 5046 | Submission Open
Keywords: long COVID; post-COVID; cognitive dysfunction; virus; cognition; brain; viral infection; virol-ogy; RNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Hematological Malignancies and Benign Hematological Disorders—3rd Edition submission deadline 20 Nov 2025 | 3 articles | Viewed by 5032 | Submission Open
Keywords: myeloproliferative neoplasms; leukemia; lymphoma; multiple myeloma; oxidative stress; inflammation; microbiome; genetics; molecular biology
(This special issue belongs to the Section Molecular Biology)
Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4939 | Submission Open
Keywords: molecular detection; analytical techniques; nanosensors; food science; DNA analysis
(This special issue belongs to the Section Biochemistry)
Hypertension: Mechanisms of Oxidative Stress and Antioxidant Regulation
edited by Rossana Scuri
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4899 | Submission Open
Keywords: arteriolar networks organization; blood flow supply; cardiovascular disease; endothelial dysfunction; eNOS regulatory activity; oxidative stress; polyphenols
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolomics in the Field of Autoimmune Diseases submission deadline 20 Nov 2025 | 2 articles | Viewed by 4862 | Submission Open
Keywords: metabolomics; proteomics; genomics; transcriptomics; biomarkers; autoimmune diseases; inflammatory diseases; nuclear magnetic resonance spectroscopy; mass spectrometry; precision medicine
(This special issue belongs to the Section Molecular Immunology)
New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes, 2nd Edition submission deadline 20 Nov 2025 | 2 articles | Viewed by 4832 | Submission Open
Keywords: extracellular vesicles; exosomes intercellular; crosstalk liquid biopsy carcinogenesis; cell differentiation tissue; homeostasis; organ remodeling; biomedicine; advanced diagnostics
(This special issue belongs to the Section Molecular Immunology)
Recent Developments in Omics Technologies Applied to Oncology Research
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4761 | Submission Open
Keywords: single‑cell genome sequencing; single‑cell epigenome sequencing; single‑cell CRISPR sequencing; imaging mass cytometry; RNAscope; digital spatial profiling; multiplex IHC; multiplex IF; omics technologies
(This special issue belongs to the Section Molecular Oncology)
Therapeutic Potential of Natural Compounds: Insights into Mechanisms, Molecular Docking, and Biological Activities, 2nd Edition submission deadline 20 Nov 2025 | 6 articles | Viewed by 4745 | Submission Open
Keywords: natural compounds; synthetic derivatives of natural compounds; biological activity; mechanism of action; molecular docking; therapeutic potential; anticancer; antimicrobial; antiviral; anti-civilization diseases; antiobesity; antidiabetes; preventing the development of cardiovascular diseases; including myocardial infarction; hypertension and ischemic heart disease; food hypersensitivity; antiallergy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Genome Structure, Function and Dynamic Regulation of Cell Fate
edited by Georg Hildenbrand and
submission deadline 20 Nov 2025 | 1 articles | Viewed by 4718 | Submission Open
Keywords: genome structure and organization; DNA sequence patterning and functional genomics; epigenetic regulation and chromatin remodeling; DNA damage response and cellular developments; cellular differentiation and cell fate; transcriptional control; chromatin architecture
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Micro- and Nanomaterials for Biomedical Applications
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4704 | Submission Open
Keywords: biomaterials; medical applications; natural and synthetic polymers; tissue engineering; hydrogels; bone cement; drug delivery systems; dendrimers; micro- and nanocomposites; nanotechnology; bioceramics; biopharmaceutics; biosensing
(This special issue belongs to the Section Molecular Nanoscience)
Therapeutics and Pathophysiology of Cognitive Dysfunction
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 4620 | Submission Open
Keywords: cognition; neurologic diseases; neuroinflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
FTIR Miscrospectroscopy: Opportunities and Challenges
edited by Simona Sabbatini
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4572 | Submission Open
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Hematological Malignancies: Molecular Mechanisms and Therapy, 2nd Edition
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 4569 | Submission Open
Keywords: hematological malignancies; molecular pathways; genetics; immunopathogenesis; biomarkers; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Cardiovascular Disease, 3rd Edition submission deadline 20 Nov 2025 | 5 articles | Viewed by 4558 | Submission Open
Keywords: atherosclerosis; cardiovascular disease; endothelial cells; matrix metalloproteinases; biomarkers; miRNAs; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lignocellulose Bioconversion and High-Value Utilization
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 4491 | Submission Open
Keywords: lignocellulosic biomass; including seed husks from grains; enzymes; microorganisms producing enzymes; chemical catalysts; biomass conversion; biofuels; bioproducts; fermentable sugars; biomass-based functional materials; lignocellulose nanoparticles
(This special issue belongs to the Section Macromolecules)
Genetic and Epigenetic Analyses in Cancer
edited by Jing Gong
submission deadline 20 Nov 2025 | 4 articles | Viewed by 4402 | Submission Open
Keywords: epigenetics; genetic mutations; chromosomal instability; DNA methylation; histone modifications; non-coding rnas; multi-omics; transcriptomics; proteomics; drug resistance in cancer; cancer biomarkers; therapeutic targets in cancer
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Therapeutic Targets for Neuroinflammation and Neurodegeneration
edited by Muhammad Sohail Khan and
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4391 | Submission Open
Keywords: neurodegenerative diseases; inflammatory response; nervous system; neuroinflammations
(This special issue belongs to the Section Molecular Neurobiology)
Plant-Derived Bioactive Compounds for Pharmacological Applications submission deadline 20 Nov 2025 | 5 articles | Viewed by 4310 | Submission Open
Keywords: plant-derived bioactive compounds; pharmacological applications; antioxidant activity; anti-inflammatory agents; antimicrobial properties; neuroprotective effects; drug discovery; high-throughput screening; extraction and isolation techniques; structural characterization; CRISPR technology; genome editing; bioprocess engineering; bioreactor production; therapeutic potential; metabolite profiling
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Studies of Monogenic Diseases: Diagnostics, Mechanisms and Therapeutics
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 4223 | Submission Open
Keywords: cell death pathways; DNA sequencing; drug discovery; gene expression; gene mutation; genetic diagnosis; molecular signaling; molecular therapy; monogenic disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Perspectives in Lung Diseases: Pathogenesis, Diagnosis, and Treatment
edited by
submission deadline 20 Nov 2025 | 5 articles | Viewed by 4122 | Submission Open
Keywords: lung cancer models; cancer stem cells; tumor microenvironment; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Response to Drought, Heat, and Light Stress
edited by Mengzhu Lu and Shijiang Cao
submission deadline 20 Nov 2025 | 4 articles | Viewed by 4083 | Submission Open
Keywords: plant stress response; molecular biology techniques; bioinformatics; genetic mechanisms; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
Editorial Board Members’ Collection Series: “Protein Biophysics” submission deadline 20 Nov 2025 | 2 articles | Viewed by 4051 | Submission Open
Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation
(This special issue belongs to the Section Molecular Biophysics)
New Insights in Plant Cell Biology submission deadline 20 Nov 2025 | 4 articles | Viewed by 4005 | Submission Open
Keywords: chloroplasts; cell wall; vacuoles; microtubule cytoskeleton; plant-cell-specific structures
(This special issue belongs to the Section Molecular Plant Sciences)
Pharmacology and Toxicology of Synthetic and Natural Products
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 3825 | Submission Open
Keywords: pharmacology and toxicology; pharmacodynamics and pharmacokinetics; synthetic drugs; natural products; drug interactions; molecular mechanisms; therapeutic potential; adverse effects; dose– response relationship; drug safety and efficacy
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Biology of Soybean
edited by Zhengjun Xia
submission deadline 20 Nov 2025 | 5 articles | Viewed by 3759 | Submission Open
Keywords: soybean; growth and development; disease resistance; nodulation; nolecular mechanism; plant interaction
(This special issue belongs to the Section Molecular Plant Sciences)
Deciphering Molecular Complexity of Pancreatic Cancer submission deadline 20 Nov 2025 | 2 articles | Viewed by 3717 | Submission Open
Keywords: pancreatic cancer; intratumor heterogeneity; bulk and single-cell multiomics; tumor microenvironment; cancer immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer submission deadline 20 Nov 2025 | 1 articles | Viewed by 3643 | Submission Open
Keywords: TGF-beta; fibrosis; inflammation; cancer; immune cells; fibroblasts; EMT; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Unraveling Apoptosis: Deciphering Molecular Mechanisms
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3571 | Submission Open
Keywords: apoptosis; development; microenvironment; mitochondria dysfunction; molecular mechanisms; tumors; degenerative diseases; diabetes; metabolic diseases; neurodegenerative disease; novel pharmacological strategies
(This special issue belongs to the Section Biochemistry)
Molecular Research on Pathogenesis and Treatment of Pregnancy Complications
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 3546 | Submission Open
Keywords: hypertensive disorders of pregnancy; preeclampsia; molecular biology; biomarker; prevention; therapeutics; placenta
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products and Synthetic Compounds for Drug Development: 3rd Edition
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 3461 | Submission Open
Keywords: reactive oxygen; anti-inflammation; cancer; infectious diseases; liver diseases; lung disease; kidney disease; cardiac disease; neuro disease
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research and Potential Effects of Medicinal Plants
edited by
submission deadline 20 Nov 2025 | 4 articles | Viewed by 3453 | Submission Open
Keywords: medicinal plants; natural products; disease treatment; drug screening; bioassays
(This special issue belongs to the Section Molecular Plant Sciences)
Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets
edited by Jue Wang
submission deadline 20 Nov 2025 | 2 articles | Viewed by 3450 | Submission Open
Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular Oncology)
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