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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on Enzymes in Biocatalysis

edited by

Simona Varriale

Samuel De Visser

and

Salvatore Fusco

submission deadline 31 Aug 2025 | Viewed by 159 | Submission Open

Keywords: biocatalysis; bioprocess; enzyme immobilization; enzyme production; response surface methodology (RSM); enzymatic-assisted extraction; enzymatic-catalyzed synthesis; enzyme modelling; bioreactor; bioconversion; cascade biocatalysis; enzymatic kinetic; enzyme engineering; ultrasound-assisted enzymatic reaction; directed evolution; machine learning-assisted enzyme engineering; waste-to-value bioprocesses

(This special issue belongs to the Section Biochemistry)

Endocrinology of Pregnancy

edited by

Georgios Valsamakis

submission deadline 31 Aug 2025 | Viewed by 157 | Submission Open

Keywords: pregnancy; endocrine system; fetal development; maternal health; metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Neurodegenerative Disorders: Advances in Mechanisms, Models, and Therapeutics

edited by Craig Bennett

submission deadline 31 Aug 2025 | Viewed by 156 | Submission Open

Keywords: TDP-43; C9orf72; dipeptide repeat; proteotoxicity; cryptic exon exclusion; L-BMAA

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into the Molecular Pathogenesis of Myeloproliferative Neoplasms

edited by

Laura Georgiana Necula

submission deadline 31 Aug 2025 | 1 articles | Viewed by 151 | Submission Open

Keywords: myeloproliferative neoplasms; molecular diagnostic; targeted therapy; biomarkers; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Selected Papers from the 1st RNA and RNase International Meeting and Related Research

edited by

Ester Boix

submission deadline 31 Aug 2025 | Viewed by 151 | Submission Open

Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA binding proteins; RNA recognition patterns; RNA catalysis

(This special issue belongs to the Section Biochemistry)

Molecular Regulation and Mechanisms of Nitric Oxide in Endothelial Cells

edited by

Roberto Berra-Romani

and

Francesco Moccia

submission deadline 31 Aug 2025 | Viewed by 150 | Submission Open

Keywords: nitric oxide (NO); endothelial cells; endothelial nitric oxide synthase (eNOS); vascular homeostasis; vasodilation; endothelial dysfunction; molecular signaling; vascular diseases; reactive oxygen species (ROS); nitric oxide regulation

(This special issue belongs to the Section Biochemistry)

Recent Progress in Synthesis, Properties, and Applications of Polyoxometalates and Their Nanocrystals

edited by

Xiang Ma

and

Pengtao Ma

submission deadline 31 Aug 2025 | Viewed by 150 | Submission Open

Keywords: polyoxometalates; POMs; metal cluster compound; inorganic chemistry; nanocrystals

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Biological Barriers: Consciousness and Mental Illness

edited by

Adonis Sfera

submission deadline 31 Aug 2025 | Viewed by 147 | Submission Open

Keywords: cell membranes; transport protein regulation; blood– brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood– saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 31 Aug 2025 | Viewed by 142 | Submission Open

Keywords: genetic diseases; genotype– phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 31 Aug 2025 | Viewed by 141 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell– cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Angiogenesis: Mechanisms, Signaling, and Therapeutic Horizons

edited by Edgar Delgado-Eckert

submission deadline 31 Aug 2025 | Viewed by 137 | Submission Open

Keywords: angiogenesis; VEGF; intracellular signaling in vascular biology; anti-angiogenic therapy for cancer; artery disease; age-related macular degeneration

(This special issue belongs to the Section Molecular Biology)

Microbiome-Immunity Crosstalk and Its Role in Health and Disease

edited by

Ana Isabel Beltrán-Velasco

and Sara Uceda

submission deadline 31 Aug 2025 | Viewed by 135 | Submission Open

Keywords: gut microbiota; immune system; nutrition; inflammatory processes; dysbiosis; neurodegenerative diseases

(This special issue belongs to the Section Molecular Microbiology)

Exploring Molecular Mechanism in Infertility

edited by

Antonio Simone Laganà

and Andrea Etrusco

submission deadline 31 Aug 2025 | Viewed by 133 | Submission Open

Keywords: infertility; molecular mechanisms; reproductive biology; genomics; epigenetics; biomarkers; assisted reproductive technologies; transcriptomics; proteomics; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Targets in Alzheimer’s Disease: From Mechanisms to Therapeutic Strategies

edited by

Mohammad Ejaz Ahmed

submission deadline 31 Aug 2025 | Viewed by 127 | Submission Open

Keywords: amyloid beta; neurodegeneration; neuroinflammation; microglia; mitochondrial dysfucntion; oxidative stress; molecular pathway; biomarkers of AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics

edited by

Myrna Gloria Candelaria

submission deadline 31 Aug 2025 | Viewed by 127 | Submission Open

Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Emerging Insights into Lymphoid Organ Development, Regulation and Therapeutic Potential

edited by Hélia Neves

submission deadline 31 Aug 2025 | Viewed by 125 | Submission Open

Keywords: thymus; immune; signaling; molecular; pathways; epigenetics; organoids; bioengineering; regeneration; clinical application

(This special issue belongs to the Section Molecular Biology)

Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments

edited by

Katarzyna B. Lewandowska

and

Monika Szturmowicz

submission deadline 31 Aug 2025 | Viewed by 125 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biotransformation and Engineering of Fungals and Microalgae

edited by Alejandro Chamizo-Ampudia

submission deadline 31 Aug 2025 | Viewed by 122 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae– fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

Cardiovascular Research: From Molecular Mechanisms to Novel Therapies

edited by Piotr Musiałek, Monika M. Gladká and Lukasz Tekieli

submission deadline 31 Aug 2025 | Viewed by 117 | Submission Open

Keywords: cardiovascular diseases; cardiovascular repair and regeneration; molecular cardiology; gene and stem cell therapy; drug and gene delivery; advanced imaging; biomarkers; tissue engineering; thrombosis and clotting abnormalities; animal models of human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Targeted Therapy of Lymphedema and Lipedema

edited by

Raghu P. Kataru

and Geoffrey E. Hespe

submission deadline 31 Aug 2025 | Viewed by 116 | Submission Open

Keywords: secondary lymphedema; breast cancer related lymphedema; chronic CD4+ T cell inflammtion Th2 driven fribrosis; lymphatic pathophysiology; tissue fibrosis; lymphovenous bypass; lymph node transplanatation; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 31 Aug 2025 | Viewed by 116 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 31 Aug 2025 | Viewed by 116 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research in Wearable Self Diagnostics: Against Microbiology Infection

edited by Suw Young Ly

submission deadline 31 Aug 2025 | Viewed by 115 | Submission Open

Keywords: in vivo; in vitro; assay; molecule; skin; AI medical doctor; semiconductor; digital signal; unmanned diagnosis treatment

(This special issue belongs to the Section Molecular Microbiology)

Epigenetics and RNA Processing Involved in Disease

edited by

Naoyuki Kataoka

submission deadline 31 Aug 2025 | Viewed by 110 | Submission Open

Keywords: RNA processing; RNA splicing; epigenetics; DNA modification; histone modification; RNA modification; RNA diseases; genetic diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 31 Aug 2025 | Viewed by 108 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment

edited by

Marco Fiore

submission deadline 31 Aug 2025 | Viewed by 108 | Submission Open

Keywords: alcohol; addiction; abuse; inflammation; neurodegeneration; cognition; neuroimmunology; oxidative stress

(This special issue belongs to the Section Molecular Biology)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 31 Aug 2025 | Viewed by 108 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

Innovative Applications of Topical Probiotics in Dermatology: Addressing Multiple Skin Disorders

edited by

Mireia Mallandrich Miret

submission deadline 31 Aug 2025 | Viewed by 105 | Submission Open

Keywords: topical probiotics in dermatology; skin microbiome; skin disorders; therapeutic applications; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Hematology: Molecular Biology and Targeted Therapies

edited by Fabio Stagno and

Stefania Stella

submission deadline 31 Aug 2025 | Viewed by 105 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 31 Aug 2025 | Viewed by 104 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

Microbial Metabolism: From Pathway Analysis to Metabolic Engineering and Synthetic Biology

edited by

Elias R. Olivera

submission deadline 31 Aug 2025 | Viewed by 102 | Submission Open

Keywords: bacteria; fungi; archeobacteria; metabolic pathways; biodegradation; biosynthesis; biotransformation; omic sciences; metabolic engineering; synthetic regulatory circuits

(This special issue belongs to the Section Molecular Microbiology)

From Diet to Health: Which Molecules or Chemicals Are at Work?

edited by Sara Baldelli

submission deadline 31 Aug 2025 | Viewed by 99 | Submission Open

Keywords: balanced diet; functional nutrition; nutraceuticals; disease prevention; bioactive biomolecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Cervical Cancer and Its Therapy

edited by Ilaria Cuccu and

Violante Di Donato

submission deadline 31 Aug 2025 | Viewed by 99 | Submission Open

Keywords: cervical cancer; cervical cancer surgery; fertility-sparing techniques; targeted therapy; immunotherapy; immune checkpoint inhibitors; DNA damage repair inhibitors; antibody– drug conjugates; precision medicine; oncological outcomes

(This special issue belongs to the Section Molecular Oncology)

Molecular Genetics and Genomics of Ruminants—Second Edition

edited by

Brad A. Freking

submission deadline 31 Aug 2025 | Viewed by 98 | Submission Open

Keywords: ruminant genomics; structural genomics; functional genomics; epigenomics; gene expression; genome sequencing; genome evolution; genome-wide association study; genomic selection; marker-assisted selection

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 31 Aug 2025 | Viewed by 97 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 31 Aug 2025 | Viewed by 95 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Cell Biology and Biochemistry of Gynaecological Cancer: Pathways to Discovering Novel Treatments

edited by

Kenny Chitcholtan

submission deadline 31 Aug 2025 | Viewed by 94 | Submission Open

Keywords: gynaecological cancer; ovarian cancer; endometrial cancer; cervical cancer; cell biology; treatment; cell metastasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Cardiovascular Disease

edited by

John A. St. Cyr

submission deadline 31 Aug 2025 | Viewed by 94 | Submission Open

Keywords: myocardium; metabolism; ischemia; function; integrity; cardiovascular; disease; infarction; failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Development Biology of Immune Cells

edited by Jacek Z. Kubiak

submission deadline 31 Aug 2025 | Viewed by 93 | Submission Open

Keywords: immune cell development; macrophages; monocytes; B-cells; T-cells; dendritic cells; NK cells

(This special issue belongs to the Section Molecular Immunology)

Novel Mechanisms of Receptor Activation

edited by

Zong-Jie Cui

submission deadline 31 Aug 2025 | Viewed by 93 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure– function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “ orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way

edited by

Mariano Francesco Caratozzolo

submission deadline 31 Aug 2025 | Viewed by 93 | Submission Open

Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: Molecular Diagnosis and Treatment

edited by

Teresa Lettini

submission deadline 31 Aug 2025 | Viewed by 90 | Submission Open

Keywords: molecular pathology; melanoma; skin cancer; molecular pathway; dermatopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Pathogenic Mechanisms to Therapy in Retinal Diseases

edited by

Nan-Kai Wang

and

Eugene Yu Chuan Kang

submission deadline 31 Aug 2025 | Viewed by 88 | Submission Open

Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pharmacogenomics: The State of the Art and Future Perspectives

edited by

Satohiro Masuda

submission deadline 31 Aug 2025 | Viewed by 87 | Submission Open

Keywords: G-protein-coupled receptors; membrane transporters; drug-metabolizing enzyme; endocytosis receptors; companion diagnostic (CDx); data science in pharmacogenomics; precision medicine with pharmacogenomics; siRNA; microRNA; drug-induced organ injury; drug-induced adverse reactions

(This special issue belongs to the Section Molecular Pharmacology)

Focus on the Tryptophan Pathway

edited by

Burkhard Poeggeler

submission deadline 31 Aug 2025 | 1 articles | Viewed by 85 | Submission Open

Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan

(This special issue belongs to the Section Molecular Biology)

Molecular Techniques to Study Food Safety Challenges

edited by

María J. Andrade

and

Micaela Álvarez

submission deadline 31 Aug 2025 | Viewed by 85 | Submission Open

Keywords: food safety; hazards; foodborne pathogens; advanced microbial detection technologies; omics techniques; preventive measures

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Immunotherapy in Cancer

edited by Magdalena Król

submission deadline 31 Aug 2025 | Viewed by 82 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; monoclonal antibodies; cytokine signaling; tumor immune evasion; metabolic regulation in cancer; cell-based therapies

(This special issue belongs to the Section Molecular Immunology)

HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis

edited by

Rosemary Kiernan

submission deadline 31 Aug 2025 | Viewed by 82 | Submission Open

Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions

(This special issue belongs to the Section Molecular Immunology)

Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms

edited by

Dong-Sung Lee

and Chi-Su Yoon

submission deadline 31 Aug 2025 | Viewed by 82 | Submission Open

Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms

edited by

Ning Liu

submission deadline 31 Aug 2025 | Viewed by 81 | Submission Open

Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 1001-1050 on page 21 of 68.

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