Clinical Diagnostics and Treatment of Macular Degeneration
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".
Deadline for manuscript submissions: 25 February 2025 | Viewed by 52
Special Issue Editors
Interests: medical and surgical retina; AMD, inherited retinal diseases; multi-modal retinal imaging; retinal gene therapy
Interests: widefield OCT; adaptive optics OCT; diabetic retinopathy; age-related macular degeneration; multimodal imaging; minimally invasive vitreoretinal surgery; retinal pigment epithelium
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly, fueling advancements in diagnostics and treatment. Multi-modal retinal imaging enables early detection, subtype characterization, and treatment response assessment. Integrating artificial intelligence (AI) with these imaging modalities enhances precision, allowing quantitative measurements and predictive algorithms for risk stratification and therapy response.
Novel treatments for neovascular AMD and geographic atrophy have expanded the therapeutic options for retinal specialists. Dual inhibition targeting both VEGF and Ang-2, along with high-dose aflibercept, provides longer durability and improved efficacy. Anti-VEGF biosimilars offer cost-effective alternatives with comparable safety profiles. Long-term release devices like the port delivery system (PDS) and gene therapy strategies aim to improve outcomes and reduce injection frequency.
For geographic atrophy, the recent U.S. approval of complement factor 5 and 3 inhibitors marks a significant step, despite ongoing debates about their efficacy and safety. Complement inhibition seeks to slow disease progression, offering new therapeutic avenues. Photobiomodulation, particularly for early-stage disease, leverages light therapy to modulate cellular functions and mitigate disease progression. These innovations reflect the dynamic landscape of AMD treatment, offering new hope and opportunities for better patient outcomes.
Dr. Moreno Menghini
Dr. Andreas Pollreisz
Guest Editors
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Keywords
- age-related macular degeneration
- AMD
- geographic atrophy
- optical coherence tomography
- OCT
- artificial intelligence
- AI
- anti-VEGF
- anti-ANG2
- complement inhibition
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