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Management of Recurrent Gastroesophageal Reflux Disease (GERD)
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Management of Recurrent Gastroesophageal Reflux Disease (GERD)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (10 January 2024) | Viewed by 6181

Special Issue Editors

Dr. Ahamed Khalyfa

E-Mail Website
Guest Editor
Internal Medicine, Franciscan Health, Olympia Fields, Mishawaka, IN, USA
Interests: gastrointestinal disorders; GERD; therapeutic endoscopy; gastroenterology; hepatology; inflammatory bowel disease; advanced endoscopy; microbiome; gastrointestinal malignancies
Dr. Kamran Ayub

E-Mail Website
Guest Editor
Silver Cross Medical Center, Oak Brook, New Lenox, IL, USA
Interests: gastroesophageal reflux disease; upper endoscopy; transoral incisionless fundoplication; anti reflux mucosectomy and resection plication; barrett esophagus; proton pump inhibitor therapy

Special Issue Information

Dear Colleagues,

Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal conditions. In most cases, proton pump inhibitors (PPIs) are effective in healing esophageal lesions and improving symptoms. However, up to 40% of GERD patients do not respond well to PPI treatment. With this in mind, recurrent GERD is a challenging problem given its negative effects on patients’ quality of life. In addition to PPI therapy, many other pharmacologic therapies have been suggested for recurrent GERD, such as histamine-2 receptor blockers, prokinetics, gamma aminobutyric acid-B receptor blockers, and pain modulators. If medical therapy fails, surgical interventions such as laparoscopic anti reflux surgery (LARS), and endoscopic interventions, including endoscopic transoral incisionless fundoplication (TIF), magnetic sphincter augmentation (LINX), or radiofrequency therapy (Stretta) have been utilized. However, much remains to be discovered regarding these therapies in order to be able to provide these patients with long-term relief from GERD.

The present Special Issue aims to highlight recent advances in the management of recurrent gastroesophageal reflux disease, focusing on updates in pharmacologic and interventional therapies that are available for this patient population. 

Dr. Ahamed Khalyfa
Dr. Kamran Ayub
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • GERD
  • recurrent GERD
  • transoral incisionless fundoplication
  • magnetic sphincter augmentation
  • pharmacologic treatment of recurrent GERD
  • endoscopic full thickness plication
  • radiofrequency therapy for GERD

Published Papers (3 papers)

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Research

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6 pages, 543 KiB  
Article
Utilization of Antireflux Mucosectomy and Resection and Plication: A Novel Approach for the Management of Recurrent Gastroesophageal Reflux Disease after Prior Nissen Fundoplication or Transoral Incisionless Fundoplication
by Navkiran Randhawa, Ahamed Khalyfa, Mahnoor Khan, Christopher Roebuck, Mahnoor Inam and Kamran Ayub
J. Clin. Med. 2022, 11(23), 7141; https://doi.org/10.3390/jcm11237141 - 1 Dec 2022
Cited by 1 | Viewed by 1584
Abstract
Background: Nissen Fundoplication (NF) and Transoral Incisionless Fundoplication (TIF) are established procedures for the treatment of gastroesophageal reflux disease (GERD). However, the surgically induced plication can loosen over time. This multicenter study aims to evaluate the safety and efficacy of Antireflux Mucosectomy [...] Read more.
Background: Nissen Fundoplication (NF) and Transoral Incisionless Fundoplication (TIF) are established procedures for the treatment of gastroesophageal reflux disease (GERD). However, the surgically induced plication can loosen over time. This multicenter study aims to evaluate the safety and efficacy of Antireflux Mucosectomy (ARMS) and Resection and Plication (RAP) in symptomatic patients with prior NF or TIF that has become loose. Patients and methods: Eighteen patients were enrolled in the study. Ten had prior TIF, while eight had prior NF. Half of these patients had a Hill Grade 3 Valve while the other half had a Hill Grade 2 valve. Endoscopic submucosal dissection (ESD) was performed in six patients, while endoscopic mucosal resection (EMR) was performed in twelve patients. A follow-up endoscopy was performed at 4–12 weeks. Results: At follow-up, 11 patients had a Hill Grade 1 valve, and seven patients had a Hill Grade 2 valve. All patients had improvement in symptoms for up to 32 months. Conclusions: In this pilot study, ARMS/RAP appears to be an effective option in patients who had prior NF or TIF with recurrent GERD symptoms. Full article
(This article belongs to the Special Issue Management of Recurrent Gastroesophageal Reflux Disease (GERD))
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Review

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19 pages, 1245 KiB  
Review
Heartburn’s Hidden Impact: A Narrative Review Exploring Gastroesophageal Reflux Disease (GERD) as a Cardiovascular Disease Risk Factor
by Jacob J. Gries, Bing Chen, Salim S. Virani, Hafeez Ul Hassan Virk, Hani Jneid and Chayakrit Krittanawong
J. Clin. Med. 2023, 12(23), 7400; https://doi.org/10.3390/jcm12237400 - 29 Nov 2023
Cited by 1 | Viewed by 2211
Abstract
Gastroesophageal reflux disease (GERD) is a very common disease with an estimated 442 million cases worldwide. It is a well-documented independent risk factor for many gastrointestinal pathologies, however, its role in cardiovascular disease (CVD) is unclear, despite its high prevalence in patients with [...] Read more.
Gastroesophageal reflux disease (GERD) is a very common disease with an estimated 442 million cases worldwide. It is a well-documented independent risk factor for many gastrointestinal pathologies, however, its role in cardiovascular disease (CVD) is unclear, despite its high prevalence in patients with CVD. Although traditionally considered a causative agent of noncardiac chest pain, a common imitator of cardiac chest pain, or an incidentally shared comorbidity in patients with CVD, a number of studies have implicated GERD and its therapies as risk factors for CVD. This narrative review will explore the relationship between GERD and CVD, including medical and mechanical therapeutic approaches for GERD that could potentially impact the incidence, progression, and mortality of CVD. Full article
(This article belongs to the Special Issue Management of Recurrent Gastroesophageal Reflux Disease (GERD))
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23 pages, 2845 KiB  
Review
Gastroesophageal Reflux Disease in Obesity: Bariatric Surgery as Both the Cause and the Cure in the Morbidly Obese Population
by Muaaz Masood, Donald Low, Shanley B. Deal and Richard A. Kozarek
J. Clin. Med. 2023, 12(17), 5543; https://doi.org/10.3390/jcm12175543 - 25 Aug 2023
Cited by 4 | Viewed by 1730
Abstract
Gastrointestinal reflux disease (GERD) is a chronic, highly prevalent condition in the United States. GERD can significantly impact quality of life and lead to complications including aspiration pneumonia, esophageal stricture, Barrett’s esophagus (BE) and esophageal cancer. Obesity is a risk factor for GERD, [...] Read more.
Gastrointestinal reflux disease (GERD) is a chronic, highly prevalent condition in the United States. GERD can significantly impact quality of life and lead to complications including aspiration pneumonia, esophageal stricture, Barrett’s esophagus (BE) and esophageal cancer. Obesity is a risk factor for GERD, which often improves with weight loss and bariatric surgery. Though the incidence of bariatric surgery, in particular, minimally invasive sleeve gastrectomy, has risen in recent years, emerging data has revealed that the severity or new onset of GERD may follow bariatric surgery. We performed a literature review to provide a detailed analysis of GERD with an emphasis on bariatric surgery as both the cure and the cause for GERD in the morbidly obese population. We also describe the pathophysiological mechanisms, management approach and treatment strategies of GERD following bariatric surgery. Full article
(This article belongs to the Special Issue Management of Recurrent Gastroesophageal Reflux Disease (GERD))
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