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Journal of Clinical Medicine, Volume 13, Issue 12

2024 June-2 - 273 articles

Cover Story: Human cytomegalovirus (hCMV) is the most common etiological agent of congenital infections seen in newborns. Ocular complications of congenital CMV (cCMV) are a topic rarely addressed in the literature. English-language literature published between April 2000 and November 2023 was analyzed for ocular complications of cCMV. Ophthalmic complications of cCMV can cause severe visual disturbances. Ophthalmic diagnosis in newborns should include hCMV PCR testing, which has the highest sensitivity and specificity. In the symptomatic form of cCMV, treatment should be instituted according to recommendations. A consensus should be established for the screening of primary hCMV infection in pregnant women, the way in which to define the symptomatic form of cCMV, and the appropriateness and standards of treatment for primary hCMV infection in pregnant women. View this paper
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Articles (273)

  • Article
  • Open Access
3 Citations
2,787 Views
15 Pages

20 June 2024

Background: Chronic kidney disease (CKD) elevates the risk of cardiovascular disease (CVD) and mortality. Uremic cardiomyopathy, frequently observed in CKD and end-stage renal disease (ESRD), involves alterations in cardiac structure and function, wh...

  • Article
  • Open Access
3,048 Views
15 Pages

Bone Scintigraphy for Guidance of Targeted Treatment of Vertebral Compression Fractures

  • Elite Arnon-Sheleg,
  • Daniel Weiner,
  • Saeda Haj,
  • Alon Rod and
  • Nimrod Rahamimov

20 June 2024

Background: Vertebral compression fractures (VCFs) are prevalent in the elderly population and might be the source of back pain if they are fresh and yet unhealed. In many cases, it is a diagnostic challenge to differentiate fresh VCFs from healed un...

  • Article
  • Open Access
2 Citations
2,122 Views
12 Pages

Validation of Tracheal Sound-Based Respiratory Effort Monitoring for Obstructive Sleep Apnoea Diagnosis

  • Mireia Muñoz Rojo,
  • Renard Xaviero Adhi Pramono,
  • Nikesh Devani,
  • Matthew Thomas,
  • Swapna Mandal and
  • Esther Rodriguez-Villegas

20 June 2024

Background: Respiratory effort is considered important in the context of the diagnosis of obstructive sleep apnoea (OSA), as well as other sleep disorders. However, current monitoring techniques can be obtrusive and interfere with a patient’s n...

  • Article
  • Open Access
2,512 Views
11 Pages

Assessing the Impact of Simulated Color Vision Deficiency on Ophthalmologists’ Ability to Differentiate between Choroidal Melanoma and Choroidal Nevus

  • Yacoub A. Yousef,
  • Fawzieh Alkhatib,
  • Mutasem Elfalah,
  • Saif Aldeen AlRyalat,
  • Mona Mohammad,
  • Omar AlHabahbeh,
  • Reem AlJabari,
  • Sandrine Zweifel,
  • Ibrahim AlNawiaseh and
  • Mario Damiano Toro
  • + 1 author

20 June 2024

Background: Color vision deficiency (CVD) is an often-overlooked issue within the medical community, and its consequences remain insufficiently explored. We aim to evaluate how CVD affects diagnostic accuracy and distinguish between malignant choroid...

  • Article
  • Open Access
1 Citations
1,397 Views
10 Pages

The ‘Radiant Effect’: Recent Sonographic Image-Enhancing Technique and Its Impact on Nuchal Translucency Measurements

  • Arne Bergsch,
  • Jan Degenhardt,
  • Rüdiger Stressig,
  • Heiko Dudwiesus,
  • Oliver Graupner and
  • Jochen Ritgen

20 June 2024

Background: This study assesses the effects of the ‘Radiant’ image enhancement technique on fetal nuchal translucency (NT) measurements during first-trimester sonographic exams. Methods: A retrospective analysis of 263 ultrasound images o...

  • Article
  • Open Access
4 Citations
2,314 Views
11 Pages

20 June 2024

Background/Objectives: Dyslipidemia is a well-established risk factor for cardiovascular disease (CVD). However, among available drug treatments, only those targeted at lowering LDL-C and consequently TC have demonstrated efficacy in preventing CVD....

  • Case Report
  • Open Access
2,434 Views
15 Pages

Raghib Syndrome and Pulmonary Arterial Hypertension in a Pediatric Patient: Case Report and Literature Review

  • Liliana Gozar,
  • Maria Oana Săsăran,
  • Marius Cătălin Cosma,
  • Daniela Toma,
  • Andreea Georgiana Nan and
  • Horea Gozar

20 June 2024

Background: Raghib syndrome is a rare malformation complex consisting of the drainage of the left superior vena cava (LSVC) into the left atrium, ostial atresia of the coronary sinus and an atrial septal defect (ASD). Case Report: This report aims to...

  • Feature Paper
  • Article
  • Open Access
2 Citations
1,654 Views
12 Pages

Prognostic Role of OX40, LAG-3, TIM-3 and PD-L1 Expression in Bone and Soft Tissue Sarcomas

  • Bediz Kurt İnci,
  • Elif Acar,
  • Fatih Gürler,
  • Ayşegül İlhan,
  • Fatih Yıldız,
  • Fisun Ardıç,
  • Berna Öksüzoğlu,
  • Nuriye Özdemir,
  • Ahmet Özet and
  • Ozan Yazıcı
  • + 1 author

20 June 2024

Introduction: The current study aims to evaluate the OX40, TIM-3, LAG-3, and PD-L1 targeted pathways in the regulation of T-cell activity in sarcoma patients to determine their relationship with overall survival (OS). Method: This study included one...

  • Article
  • Open Access
1 Citations
1,882 Views
14 Pages

Lower Abdominal vs. Lateral Thigh Perforator Flaps in Microsurgical Sarcoma Reconstruction: The Aesthetics of Donor Site Matters

  • Beniamino Brunetti,
  • Rosa Salzillo,
  • Riccardo De Bernardis,
  • Valeria Petrucci,
  • Matteo Pazzaglia,
  • Chiara Camilloni,
  • Alessandra Putti,
  • Marco Morelli Coppola,
  • Stefania Tenna and
  • Paolo Persichetti

20 June 2024

Introduction: Sarcoma resection often leaves patients with big defects only amenable through microsurgical reconstruction. In such cases, it is hard for the surgeon to uphold low donor-site morbidity with an aesthetic result. The purpose of this stud...

  • Systematic Review
  • Open Access
7 Citations
3,978 Views
22 Pages

Effects of Exercise Rehabilitation on Cardiorespiratory Fitness in Long-COVID-19 Survivors: A Meta-Analysis

  • Sothida Nantakool,
  • Piangkwan Sa-nguanmoo,
  • Supatcha Konghakote and
  • Busaba Chuatrakoon

20 June 2024

Background: Poor cardiorespiratory fitness poses the highest risk of mortality. Long-COVID-19 survivors exhibit a reduced cardiorespiratory fitness (CRF). While exercise rehabilitation, such as cardiopulmonary exercise, is used for long-COVID-19 surv...

  • Article
  • Open Access
1 Citations
1,648 Views
12 Pages

20 June 2024

Blowout fractures are common midfacial fractures in which one or several of the bones of orbital vault break. This is usually caused by a direct trauma to the eye with a blunt object such as a fist. Fracturing of the fragile orbital bones can lead to...

  • Article
  • Open Access
7 Citations
2,369 Views
10 Pages

20 June 2024

Objective: Catheter-related bladder discomfort (CRBD) due to indwelling urinary catheterization in patients undergoing transurethral resection of the prostate (TURP) is difficult to tolerate and needs to be treated. This randomized prospective study...

  • Article
  • Open Access
2 Citations
1,478 Views
10 Pages

Improving Spiritual Well-Being of Polish Pain Outpatients: A Feasibility Mixed Methods Study

  • Maciej Wiktor Klimasiński,
  • Ewa Baum,
  • Katarzyna Wieczorowska-Tobis and
  • Bogusław Stelcer

20 June 2024

Introduction: A physician in a chronic pain treatment clinic must recognize that the relationship between pain and spirituality is bidirectional. Chronic pain can decrease the level of spiritual well-being, and low spiritual well-being can also signi...

  • Article
  • Open Access
2 Citations
1,390 Views
11 Pages

20 June 2024

Background: Shorter hip stems have shown promising mid-term results but lack long-term data. High rates of distal cortical hypertrophy (CH) have been described, suggesting a more diaphyseal load transmission. This study aimed to determine patient-spe...

  • Feature Paper
  • Article
  • Open Access
2 Citations
1,670 Views
13 Pages

20 June 2024

Neck pain is a pathology with a high impact in terms of physical disability in modern society. The position of the head is related to neck pain. The Frankfort plane determines the position of the skull in space. The profile photograph of the subjects...

  • Article
  • Open Access
2,478 Views
11 Pages

The Chimeric LFC and DCIA Flap in Combined Mandibular and Condylar Head and Neck Reconstruction—A Case Series

  • Christoph Steiner,
  • Maximilian Neubert,
  • Gian B. Bottini,
  • Shinnosuke Nogami,
  • Katharina Zeman-Kuhnert and
  • Alexander Gaggl

20 June 2024

Background: Defects of the ascending ramus of the mandible, including the condylar head and neck or the whole temporomandibular joint (TMJ), are difficult to reconstruct. Reconstruction is mainly based on the use of alloplastic joint prosthesis, cost...

  • Systematic Review
  • Open Access
6 Citations
3,962 Views
19 Pages

Combined Central and Peripheral Demyelination (CCPD) Associated with MOG Antibodies: Report of Four New Cases and Narrative Review of the Literature

  • Marianna Papadopoulou,
  • Dimitrios Tzanetakos,
  • Christos Moschovos,
  • Anastasia Korona,
  • George Vartzelis,
  • Konstantinos Voudris,
  • Stella Fanouraki,
  • Evangelia-Makrina Dimitriadou,
  • Georgios Papadimas and
  • Georgios Tsivgoulis
  • + 2 authors

20 June 2024

Background/Objectives: Myelin oligodendrocyte glycoprotein (MOG) is exclusively expressed in the central nervous system (CNS) and is found on the outer surface of oligodendrocytes. Antibodies to MOG are associated with CNS demyelination, whereas peri...

  • Review
  • Open Access
15 Citations
13,823 Views
35 Pages

Novel Treatment Strategies for Hormone Receptor (HR)-Positive, HER2-Negative Metastatic Breast Cancer

  • Antonella Ferro,
  • Michela Campora,
  • Alessia Caldara,
  • Delia De Lisi,
  • Martina Lorenzi,
  • Sara Monteverdi,
  • Raluca Mihai,
  • Alessandra Bisio,
  • Mariachiara Dipasquale and
  • Yari Ciribilli
  • + 1 author

20 June 2024

Estrogen receptor (ER)-positive breast cancer (BC) is the most common BC subtype. Endocrine therapy (ET) targeting ER signaling still remains the mainstay treatment option for hormone receptor (HR)-positive BC either in the early or in advanced setti...

  • Review
  • Open Access
12 Citations
6,932 Views
13 Pages

20 June 2024

Viscoelastic testing is increasingly being used in clinical and research settings to assess hemostasis. Indeed, there are potential situations in which viscoelastic testing is reportedly superior to standard routine laboratory testing for hemostasis....

  • Article
  • Open Access
3 Citations
3,495 Views
11 Pages

20 June 2024

Background: The goal of this study was to evaluate the effect of extracorporeal membrane oxygenation (ECMO) on mortality in patients with cardiogenic shock excluding Impella and IABP use. Method: The large Nationwide Inpatient Sample (NIS) database w...

  • Article
  • Open Access
2 Citations
2,032 Views
10 Pages

Clinical Characteristics of Cutaneous Pain in Psoriasis

  • Magdalena Kotewicz,
  • Piotr K. Krajewski,
  • Andrzej K. Jaworek and
  • Jacek C. Szepietowski

20 June 2024

Background: Psoriasis is a common inflammatory disease that is often associated with itch and pain. This study aimed to evaluate the clinical characteristics of skin pain among patients with psoriasis. Materials: A total of 106 patients diagnosed wit...

  • Article
  • Open Access
1 Citations
2,083 Views
12 Pages

Is Feto-Maternal Transfusion after Cesarean Delivery Different in Singleton and Twin Pregnancy?

  • Anna Stachurska-Skrodzka,
  • Damian Mielecki,
  • Anna Fijałkowska,
  • Kinga Żebrowska,
  • Monika Kasperczak and
  • Katarzyna Kosińska-Kaczyńska

20 June 2024

Background: The aim of the study was to investigate if feto-maternal transfusion was related to the size of the fetal-maternal interface, and, therefore, was larger in twin pregnancy in comparison with singleton pregnancy. Methods: Blood samples from...

  • Brief Report
  • Open Access
1,455 Views
6 Pages

Discontinuation of Palliative Brain Radiotherapy in Patients with Brain Metastases: A Case–Control Study

  • Paul Windisch,
  • Jamie Lütscher,
  • Robert Förster,
  • Daniel R. Zwahlen and
  • Christina Schröder

20 June 2024

Background: Discontinuation of radiotherapy is rarely discussed in the scientific literature. The goal of this study was, therefore, to estimate the frequency of and reasons for treatment discontinuations in patients receiving radiotherapy for brain...

  • Article
  • Open Access
2 Citations
7,335 Views
10 Pages

Efficacy of Vonoprazan vs. Intravenous Proton Pump Inhibitor in Prevention of Re-Bleeding of High-Risk Peptic Ulcers: A Randomized Controlled Pilot Study

  • Tanawat Pattarapuntakul,
  • Thanawin Wong,
  • Panu Wetwittayakhlang,
  • Nisa Netinatsunton,
  • Suriya Keeratichananont,
  • Apichat Kaewdech,
  • Sawangpong Jandee,
  • Naichaya Chamroonkul,
  • Pimsiri Sripongpun and
  • Peter L. Lakatos

20 June 2024

Background: Proton pump inhibitor (PPI) therapy is well-established for its effectiveness in reducing re-bleeding in high-risk peptic ulcer patients following endoscopic hemostasis. Vonoprazan (VPZ) has demonstrated the capacity to achieve gastric pH...

  • Article
  • Open Access
2 Citations
2,740 Views
14 Pages

Reliability of the AI-Assisted Assessment of the Proximity of the Root Apices to Mandibular Canal

  • Wojciech Kazimierczak,
  • Natalia Kazimierczak,
  • Kamila Kędziora,
  • Marta Szcześniak and
  • Zbigniew Serafin

20 June 2024

Background: This study evaluates the diagnostic accuracy of an AI-assisted tool in assessing the proximity of the mandibular canal (MC) to the root apices (RAs) of mandibular teeth using computed tomography (CT). Methods: This study involved 57 patie...

  • Article
  • Open Access
2 Citations
4,527 Views
20 Pages

Diagnostic Performance of F-18 FDG PET/CT in the Detection of Recurrent Colorectal Cancer: Correlation with Biochemical Markers and Conventional Imaging Modalities

  • Jasna Mihailović,
  • Jelena Roganović,
  • Ivana Starčević,
  • Ivan Nikolić,
  • Nataša Prvulović Bunović and
  • Zoran Nikin

20 June 2024

Background/Objectives: Although the role of PET/CT imaging is well established in oncology, its diagnostic value in routine monitoring for recurrent colorectal cancer (CRC) is still controversial. The aim was to evaluate the diagnostic value of F-18...

  • Article
  • Open Access
4 Citations
2,442 Views
9 Pages

Socioeconomic Status and Clinical Outcomes in Chronic Kidney Disease: Bootstrap Validation of a Simple Indicator

  • Annalisa Pitino,
  • Graziella D’Arrigo,
  • Carmela Marino,
  • Patrizia Pizzini,
  • Graziella Caridi,
  • Francesca Mallamaci,
  • Giovanni Tripepi and
  • Carmine Zoccali

20 June 2024

Background: Chronic Kidney Disease (CKD) is a complex health condition that interacts significantly with socioeconomic determinants, particularly income status and education. This study developed a simple indicator of socioeconomic status (SES), whic...

  • Article
  • Open Access
1 Citations
2,164 Views
10 Pages

The Potential Role of CA-125 as a Biomarker for Short-Term Mortality Risk in Patients with Acute Symptomatic Pulmonary Embolism

  • Crhistian-Mario Oblitas,
  • Francisco Galeano-Valle,
  • Marta-Olimpia Lago-Rodríguez,
  • Marina López-Rubio,
  • Jesús Baltasar-Corral,
  • Mercedes García-Gámiz,
  • Angielys Zamora-Trillo,
  • Luis-Antonio Alvarez-Sala Walther and
  • Pablo Demelo-Rodríguez

20 June 2024

Background: Antigen carbohydrate 125 (CA-125) is a complex glycoprotein extensively studied as a prognostic biomarker in heart failure, yet its potential role in the short-term prognosis of an acute pulmonary embolism (PE) remains unexplored. Methods...

  • Article
  • Open Access
1 Citations
1,683 Views
8 Pages

Evaluation of a Semi-Automated Wound-Halving Algorithm for Split-Wound Design Studies: A Step towards Enhanced Wound-Healing Assessment

  • Paul Julius Georg,
  • Meret Emily Schmid,
  • Sofia Zahia,
  • Sebastian Probst,
  • Simone Cazzaniga,
  • Robert Hunger and
  • Simon Bossart

20 June 2024

Background: Chronic leg ulcers present a global challenge in healthcare, necessitating precise wound measurement for effective treatment evaluation. This study is the first to validate the “split-wound design” approach for wound studies u...

  • Article
  • Open Access
1 Citations
3,408 Views
15 Pages

Normative Values for Sternoclavicular Joint and Clavicle Anatomy Based on MR Imaging: A Comprehensive Analysis of 1591 Healthy Participants

  • Theo Morgan Languth,
  • Anne Prietzel,
  • Robin Bülow,
  • Till Ittermann,
  • René Laqua,
  • Lyubomir Haralambiev,
  • Axel Ekkernkamp and
  • Mustafa Sinan Bakir

19 June 2024

Background: The clavicle remains one of the most fractured bones in the human body, despite the fact that little is known about the MR imaging of it and the adjacent sternoclavicular joint. This study aims to establish standardized values for the dia...

  • Article
  • Open Access
6 Citations
9,859 Views
12 Pages

19 June 2024

Background: Human papilloma virus (HPV) infection and the management of its persistence is still a great medical challenge. Recently, scientific evidence has supported the potential therapeutic effects of four combined natural molecules—epigall...

  • Article
  • Open Access
12 Citations
3,436 Views
10 Pages

19 June 2024

Background: There is no consensus on whether mechanical alignment (MA) or kinematic alignment (KA) should be chosen for total knee arthroplasty (TKA) for coronal plane alignment of the knee (CPAK) Type I with a varus arithmetic HKA (aHKA) and apex di...

  • Article
  • Open Access
2 Citations
1,701 Views
10 Pages

Surgical Outcomes of Hugo™ RAS Robot-Assisted Partial Nephrectomy for Cystic Renal Masses: Technique and Initial Experience

  • Francesco Prata,
  • Andrea Iannuzzi,
  • Francesco Tedesco,
  • Alberto Ragusa,
  • Angelo Civitella,
  • Matteo Pira,
  • Marco Fantozzi,
  • Leonilde Sica,
  • Roberto Mario Scarpa and
  • Rocco Papalia

19 June 2024

Background: The Hugo™ Robot-Assisted Surgery (RAS) system is a new cutting-edge robotic platform designed for clinical applications. Nevertheless, its application for cystic renal tumors has not yet been thoroughly investigated. In this context...

  • Article
  • Open Access
6 Citations
2,691 Views
18 Pages

Evaluation of the Dimensional Accuracy of Robot-Guided Laser Osteotomy in Reconstruction with Patient-Specific Implants—An Accuracy Study of Digital High-Tech Procedures

  • Bilal Msallem,
  • Lara Veronesi,
  • Michel Beyer,
  • Florian S. Halbeisen,
  • Michaela Maintz,
  • Adrian Franke,
  • Paula Korn,
  • Adrian Dragu and
  • Florian M. Thieringer

19 June 2024

Background/Objective: With the rapid advancement in surgical technologies, new workflows for mandibular reconstruction are constantly being evaluated. Cutting guides are extensively employed for defining osteotomy planes but are prone to errors durin...

  • Article
  • Open Access
2 Citations
2,214 Views
11 Pages

19 June 2024

Background/Objectives: Preoperative fasting guidelines traditionally aim to reduce pulmonary aspiration risk. However, concerns over the adverse effects of prolonged fasting have led to exploring alternatives. This study aimed to investigate the impa...

  • Article
  • Open Access
3 Citations
2,078 Views
13 Pages

The Role of CyberKnife Stereotactic Radiosurgery in Recurrent Cranial Medulloblastomas across Pediatric and Adult Populations

  • Kelly H. Yoo,
  • Neelan J. Marianayagam,
  • David J. Park,
  • Aroosa Zamarud,
  • Xuejun Gu,
  • Erqi Pollom,
  • Scott G. Soltys,
  • Antonio Meola and
  • Steven D. Chang

19 June 2024

Background/Objectives: Medulloblastoma is the most common malignant brain tumor in children. In recent decades, the therapeutic landscape has undergone significant changes, with stereotactic radiosurgery (SRS) emerging as a promising treatment for re...

  • Article
  • Open Access
2 Citations
1,751 Views
14 Pages

Functional and Radiological Results Following Revision Blade Plating and Cephalomedullary Nailing in Aseptic Trochanteric and Subtrochanteric Nonunion

  • Julia Rehme-Röhrl,
  • Andreas Brand,
  • Annika Dolt,
  • Dag Grünewald,
  • Reinhard Hoffmann,
  • Fabian Stuby,
  • Uwe Schweigkofler and
  • Christian von Rüden

19 June 2024

Background: Trochanteric and subtrochanteric fractures result in nonunion in more than 20% of cases. The aim of this study was to assess the functional and radiological results following revision cephalomedullary nailing and 95-degree angled blade pl...

  • Systematic Review
  • Open Access
11 Citations
10,968 Views
14 Pages

Comprehensive Insights into Metastasis-Associated Spinal Cord Compression: Pathophysiology, Diagnosis, Treatment, and Prognosis: A State-of-the-Art Systematic Review

  • Michail Vavourakis,
  • Evangelos Sakellariou,
  • Athanasios Galanis,
  • Panagiotis Karampinas,
  • Dimitrios Zachariou,
  • Georgios Tsalimas,
  • Vasileios Marougklianis,
  • Evangelia Argyropoulou,
  • Meletis Rozis and
  • Spiros G. Pneumatikos
  • + 1 author

19 June 2024

Background: Spinal cord compression is a formidable complication of advanced cancer, and clinicians of copious specialities often have to encounter significant complex challenges in terms of diagnosis, management, and prognosis. Metastatic lesions fr...

  • Article
  • Open Access
1,708 Views
12 Pages

Diagnostic Utility of Specific Frailty Questionnaire: The Kihon Checklist for Hippocampal Atrophy in COPD

  • Tsunahiko Hirano,
  • Shun Takahashi,
  • Ayumi Fukatsu-Chikumoto,
  • Kasumi Yasuda,
  • Takuya Ishida,
  • Tomohiro Donishi,
  • Kazuyoshi Suga,
  • Keiko Doi,
  • Keiji Oishi and
  • Kazuto Matsunaga
  • + 6 authors

19 June 2024

Background/Objectives: COPD patients who are frail have been reported to develop brain atrophy, but no non-invasive diagnostic tool has been developed to detect this condition. Our study aimed to explore the diagnostic utility of the Kihon Checklist...

  • Article
  • Open Access
9 Citations
4,001 Views
16 Pages

Twelve Years of the Gaucher Outcomes Survey (GOS): Insights, Achievements, and Lessons Learned from a Global Patient Registry

  • Deborah Elstein,
  • Nadia Belmatoug,
  • Bruno Bembi,
  • Patrick Deegan,
  • Diego Fernandez-Sasso,
  • Pilar Giraldo,
  • Özlem Göker-Alpan,
  • Derralynn Hughes,
  • Heather Lau and
  • Ari Zimran
  • + 7 authors

19 June 2024

Background: Long-term patient registries are important for evaluating treatment outcomes in patients with rare diseases, and can provide insights into natural disease history and progression in real-world clinical practice. Initiated in 2010, the Gau...

  • Article
  • Open Access
6 Citations
3,367 Views
18 Pages

The Effect of Obesity on Repolarization and Other ECG Parameters

  • Irena A. Dykiert,
  • Krzysztof Kraik,
  • Lidia Jurczenko,
  • Paweł Gać,
  • Rafał Poręba and
  • Małgorzata Poręba

19 June 2024

Background: Overweight and obesity are important risk factors in the development of cardiovascular diseases. New repolarization markers, such as the Tpeak-Tend interval and JTpeak intervals, have not yet been profoundly studied in obese patients. The...

  • Article
  • Open Access
2 Citations
1,601 Views
12 Pages

Non-Surgical Periodontal Therapy’s Influence on Alpha-Synuclein and Inflammatory Marker Levels: A Pilot Study

  • Patrícia Lyra,
  • João Botelho,
  • Silvia Rota,
  • Karolina Poplawska-Domaszewicz,
  • Vanessa Machado,
  • Daniela Guerreiro,
  • Luís Proença,
  • Helena Barroso,
  • José João Mendes and
  • Kallol Ray Chaudhuri

19 June 2024

Background: Microbial dysbiosis may contribute to alpha-synuclein (α-Syn) homeostasis disruption, yet the burden of inflammatory periodontal infection and its treatment have never been studied in this regard. We aimed to compare the cytokine an...

  • Article
  • Open Access
3 Citations
1,888 Views
13 Pages

Working Memory Recovery in Adolescents with Concussion: Longitudinal fMRI Study

  • Anna Manelis,
  • João P. Lima Santos,
  • Stephen J. Suss,
  • Cynthia L. Holland,
  • Courtney A. Perry,
  • Robert W. Hickey,
  • Michael W. Collins,
  • Anthony P. Kontos and
  • Amelia Versace

19 June 2024

Background: Understanding the behavioral and neural underpinnings of the post-concussion recovery of working memory function is critically important for improving clinical outcomes and adequately planning return-to-activity decisions. Previous studie...

  • Article
  • Open Access
2 Citations
2,492 Views
14 Pages

Assessing Residual Gastric Fluid Volume after Administering Diluted Oral Contrast until One Hour Prior to Anesthesia in Children: An Observational Cohort Study

  • Suryakumar Narayanasamy,
  • Robert J. Fleck,
  • Ali I. Kandil,
  • Boma Afonya,
  • Hana Mahmoud,
  • Jiwon Lee,
  • Lili Ding and
  • Mohamed A. Mahmoud

19 June 2024

Background: Gastric fluid volume has been used as a surrogate marker for pulmonary aspiration risk in studies evaluating fasting protocol safety. This study measured residual gastric fluid volume in children using a protocol in which diluted oral con...

  • Article
  • Open Access
7 Citations
1,583 Views
14 Pages

The Identification and Evaluation of Interleukin-7 as a Myokine Biomarker for Peripheral Artery Disease Prognosis

  • Ben Li,
  • Farah Shaikh,
  • Abdelrahman Zamzam,
  • Muzammil H. Syed,
  • Rawand Abdin and
  • Mohammad Qadura

19 June 2024

Background/Objectives: Myokines have been demonstrated to be associated with cardiovascular diseases; however, they have not been studied as biomarkers for peripheral artery disease (PAD). We identified interleukin-7 (IL-7) as a prognostic biomarker...

  • Review
  • Open Access
17 Citations
7,184 Views
15 Pages

19 June 2024

Dental implants have always played an important role in dentistry and have been used to replace missing teeth since around 600 AD. They can be classified into three groups: endosteal, subperiosteal, and transosteal. Over time, different materials hav...

  • Article
  • Open Access
4 Citations
2,419 Views
8 Pages

19 June 2024

Background: To determine the differences in the effects of intense pulsed light (IPL) treatment when including the upper and lower lid or lateral canthus area in patients with meibomian gland dysfunction (MGD). Methods: Patients who underwent three I...

  • Systematic Review
  • Open Access
2 Citations
7,000 Views
15 Pages

Gender-Affirming Surgery in Low- and Middle-Income Countries: A Systematic Review

  • Viraj Shah,
  • Bashar Hassan,
  • Rena Hassan,
  • Malory Alexis,
  • Myan Bhoopalam,
  • Lorreen Agandi and
  • Fan Liang

19 June 2024

Objectives: Fewer than one-fifth of all studies on gender-affirming care originate from low- and middle-income countries (LMICs). This is the first systematic review to examine surgical demographics and outcomes following gender-affirming surgery (GA...

  • Article
  • Open Access
1,613 Views
8 Pages

Assessment of the Retinal Ganglion Cell Layer after Uncomplicated Cataract Surgery

  • Bassam Abou-Jokh Rajab,
  • Carlos Doncel-Fernández,
  • Noelia Sánchez-Liñan and
  • Gracia Castro-Luna

19 June 2024

(1) Background: This research aimed to evaluate the changes in ganglion cell layer thickness (GCLT) after uncomplicated cataract surgery in patients without previous ocular pathology and the impact of the appearance of cystoid macular edema on the GC...

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J. Clin. Med. - ISSN 2077-0383