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Knee Osteoarthritis: Clinical Updates and Perspectives
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Knee Osteoarthritis: Clinical Updates and Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 2551

Special Issue Editors

Dr. Yoshitomo Saita

E-Mail Website1 Website2
Guest Editor
Regenerative Medicine for Locomotive Organ, Juntendo University School of Medicine, Tokyo 113-0033, Japan
Interests: knee osteoarthritis; prevention; pharmacological care; surgical intervention; physiotherapy; biotherapy; stem cell therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Shinnosuke Hada

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Guest Editor
Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan
Interests: knee surgery; osteoarthritis; sports medicine; regenerative medicine

Special Issue Information

Dear Colleagues,

I'm excited to announce that I will be serving as the Guest Editor for the upcoming Special Issue titled "Knee Osteoarthritis: Clinical Updates and Perspectives". I believe that the ultimate goal in the treatment of knee osteoarthritis is to extend the "healthy lifespan." There are diverse approaches to achieve this goal.

From a preventive standpoint, lifestyle improvements such as diet and exercise are crucial. Approaching populations at a higher risk of developing knee osteoarthritis in the future, considering genetic and anatomical factors, represents a novel concept. Additionally, knee-preserving osteotomies aiming for "joint preservation" have seen significant progress in recent years.

In the field of biotherapy, cell therapies using autologous platelet-rich plasma and mesenchymal stem cells, as well as treatments utilizing liquid factors such as extracellular vesicles and exosomes, have undergone explosive development. However, when considering the goal of extending a healthy lifespan, it is essential not to persist in conservative treatments unnecessarily but to perform joint replacement surgery at the appropriate time.

In the complex realm of knee joint care, where the causes of pain are intricate, the most crucial premise is to thoroughly assess the patient's physical condition and, in conjunction with imaging diagnostics, appropriately evaluate the causes of pain for effective intervention.

For this Special Issue, I aim to gather insights from specialists at the forefront of these clinical updates and perspectives. Contributions are welcomed from clinical research, basic research with clinical relevance, animal experiments, literature reviews or any other relevant fields. I encourage submissions that share cutting-edge knowledge aimed at extending the healthy lifespan of patients.

Dr. Yoshitomo Saita
Dr. Shinnosuke Hada
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • knee osteoarthritis
  • diagnosis
  • cell therapy
  • platelet-rich plasma
  • exosome
  • knee osteotomy
  • arthroplasty
  • physiotherapy
  • conservative treatment
  • surgical treatment

Published Papers (3 papers)

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13 pages, 892 KiB  
Article
Implications of Stabilometric Assessment in Determining Functional Deficits in Patients with Severe Knee Osteoarthritis: Observational Study
by Marius Neculăeș, Pablo Hernandez-Lucas and Paul Lucaci
J. Clin. Med. 2024, 13(11), 3181; https://doi.org/10.3390/jcm13113181 - 29 May 2024
Viewed by 415
Abstract
Background: Osteoarthritis is one of the most frequent joint disorders in the world. The specialists in the field strongly support the role of physical exercise as a key component in the holistic management of arthrosis. The aim of the current study was [...] Read more.
Background: Osteoarthritis is one of the most frequent joint disorders in the world. The specialists in the field strongly support the role of physical exercise as a key component in the holistic management of arthrosis. The aim of the current study was to identify and assess the functional deficit of these patients and to identify means to alleviate it through pre-surgery physiotherapy programs. Methods: The study was conducted on two samples of patients: a witness sample, encompassing 126 subjects without pathologies at the level of their lower limbs, and a study sample, formed of 116 subjects diagnosed with severe gonarthrosis with total knee arthroplasty indication. The assessment protocol was accomplished with the GPS 400 stabilometric platform. Results: The barycenter differences within the support polygon, recorded for the two samples within sagittal deviation, emphasize that the barycenter shifting mainly towards the healthy lower limb will demand, from the individual, more intense rebalancing postural reactions that will place the center-of-gravity projection in the sagittal plane, closer to the central area of the support polygon. Conclusions: In the case of gonarthrosis and other joint disorders, the use of functional testing to assess body weight distribution and center-of-gravity imbalances represents a promising direction in the research on and management of these disorders, providing essential information for functional diagnosing and thus enabling the elaboration and monitoring of individualized functional rehabilitation plans. Full article
(This article belongs to the Special Issue Knee Osteoarthritis: Clinical Updates and Perspectives)
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15 pages, 1276 KiB  
Article
Injection of Autologous Adipose Stromal Vascular Fraction in Combination with Autologous Conditioned Plasma for the Treatment of Advanced Knee Osteoarthritis Significantly Improves Clinical Symptoms
by Markus Klingenberg, Antoniya Dineva, Annika Hoyer, Barbara Kaltschmidt, Philipp Leimkühler, Thomas Vordemvenne, Andreas Elsner and Dirk Wähnert
J. Clin. Med. 2024, 13(11), 3031; https://doi.org/10.3390/jcm13113031 - 22 May 2024
Viewed by 758
Abstract
(1) Background: Osteoarthritis (OA) is the most common joint disease in the world. It is chronic, systemic, progressive and disabling. Orthobiologics have the potential to positively alter the course of this disease. Therefore, the aim of this study is to evaluate the efficacy [...] Read more.
(1) Background: Osteoarthritis (OA) is the most common joint disease in the world. It is chronic, systemic, progressive and disabling. Orthobiologics have the potential to positively alter the course of this disease. Therefore, the aim of this study is to evaluate the efficacy of SVF/ACP in the treatment of advanced osteoarthritis of the knee in an unfiltered patient population. We hypothesize that this therapy can improve the symptoms associated with osteoarthritis of the knee. We also hypothesize that there are patient-related factors that influence the efficacy of therapy. (2) Methods: Two hundred and thirteen patients with moderate to severe OA of the knee and SVF/ACP injection were recruited for this study. Patients were excluded if they did not provide informed consent or were not receiving SVF/ACP therapy. Pain, function, symptoms and quality of life were assessed using standardized scores (KOOS, WOMAC) before and after treatment. (3) Results: The VAS pain score was significantly reduced by at least 30% (p < 0.001). Knee function, as measured by the KOOS daily activity and sport scores, showed significant increases of 21% and 45%, respectively, at 6 months (p < 0.04). (4) Conclusions: Treatment of knee OA with SVF/ACP injection positively modifies the disease by significantly reducing pain and improving function. Full article
(This article belongs to the Special Issue Knee Osteoarthritis: Clinical Updates and Perspectives)
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13 pages, 661 KiB  
Systematic Review
The Relevance of Implanted Percutaneous Electrical Nerve Stimulation in Orthopedics Surgery: A Systematic Review
by Sarthak Parikh, Alexandra C. Echevarria, Brandon R. Cemenski and Travis Small
J. Clin. Med. 2024, 13(13), 3699; https://doi.org/10.3390/jcm13133699 - 25 Jun 2024
Viewed by 882
Abstract
Background: Percutaneous peripheral nerve stimulation (PNS) is a form of neuromodulation that involves the transmission of electrical energy via metal contacts known as leads or electrodes. PNS has gained popularity in orthopedic surgery as several studies have supported its use as a [...] Read more.
Background: Percutaneous peripheral nerve stimulation (PNS) is a form of neuromodulation that involves the transmission of electrical energy via metal contacts known as leads or electrodes. PNS has gained popularity in orthopedic surgery as several studies have supported its use as a pain control device for patients suffering from pain due to orthopedic pathologies involving the knee, shoulder, and foot. The purpose of this systematic review is to summarize the literature involving peripheral nerve stimulation in orthopedic surgery. The existing body of literature provides support for further research regarding the use of PNS in the management of knee pain, hip pain, shoulder pain, foot pain, and orthopedic trauma. Notably, the evidence for its efficacy in addressing knee and shoulder pain is present. Methods: This study was conducted following PRISMA guidelines. Seven hundred and forty-five unique entries were identified. Two blinded reviewers assessed each article by title and abstract to determine its relevance and categorized them as “include”, “exclude”, and “maybe”. After a preliminary review was completed, reviewers were unblinded and a third reviewer retrieved articles labeled as “maybe” and those with conflicting labels to determine their relevance. Twenty-eight articles were included, and seven hundred and seventeen articles were excluded. Articles discussing the use of PNS in the field of orthopedic surgery in patients > 18 years of age after 2010 were included. Exclusion criteria included neuropathic pain, phantom limb pain, amputation, non-musculoskeletal related pathology, non-orthopedic surgery related pathology, spinal cord stimulator, no reported outcomes, review articles, abstracts only, non-human subjects. Results: A total of 16 studies analyzing 69 patients were included. All studies were either case series or case reports. Most articles involved the application of PNS in the knee (8) and shoulder (6) joint. Few articles discussed its application in the foot and orthopedic trauma. All studies demonstrated that PNS was effective in reducing pain. Discussion: Peripheral nerve stimulation can be effective in managing postoperative or chronic pain in patients suffering from orthopedic pathology. This systematic review is limited by the scarcity of robust studies with substantial sample sizes and extended follow up periods in the existing literature. Full article
(This article belongs to the Special Issue Knee Osteoarthritis: Clinical Updates and Perspectives)
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