Advances in Surgeries for Treating Common Skin Cancers

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1036

Special Issue Editor


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Guest Editor
Dermatologic Department, Military Institute of Medicine–National Research Institute, Central Clinical Hospital Ministry of Defense, Warsaw, Poland
Interests: melanoma; non-melanoma skin cancer; dermoscopy; reflectance confocal microscopy; immunotherapy; targeted therapies; dermatologic adverse events of oncological treatment; ablative treatments
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Special Issue Information

Dear Colleagues,

Over the past few decades, there has been a large increase in the incidence of melanoma and non-melanoma skin cancers (NMSCs). Although great therapeutic progress has been made in the treatment of locally advanced and metastatic cases, mainly thanks to immunotherapy and targeted therapy, patients with a large number of skin cancers within the face and scalp, skin mets, or genetic syndromes remain a huge challenge. Neoadjuvant treatment significantly changed patient outcomes as it has the potential to downstage unresectable disease and allow for curativeintent operative resection. However, the precise preoperative diagnostics and mapping of negative margins remains challenging in lentigo maligna /lentigo maligna melanoma lesions. Reflectance confocal microscopy and Mohs microsurgery have been used as supports, although are still not widely available. The use of electrochemo-therapy and ablative treatments are alternatives for multiple NMSCs and melanoma skin metastases. New methods and techniques for reconstructive surgery of the resultant defects, supported by tissue engineering and 3D modeling, are becoming more available and continue to evolve. This Special Issue aims to present not only current achievements in the field of skin cancer surgery, but also in an interdisciplinary context along with changing therapeutic strategies.

Dr. Monika Slowinska
Guest Editor

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Keywords

  • melanoma
  • non-melanoma skin cancers
  • surgery
  • reconstruction
  • mohs microsurgery
  • ablative treatments
  • tissue engineering
  • pre-operative diagnostics

Published Papers (1 paper)

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Research

12 pages, 1917 KiB  
Article
The Long-Term Results of Electrochemotherapy in the Treatment of Patients with Locoregionally Advanced, Unresectable Melanoma
by Marcin Zdzienicki, Marcin Ziętek, Maria Krotewicz, Agnieszka Ewert-Krzemieniewska and Piotr Rutkowski
J. Clin. Med. 2024, 13(13), 3705; https://doi.org/10.3390/jcm13133705 - 25 Jun 2024
Viewed by 795
Abstract
Background/Objectives: Despite observing progress in recent years in the treatment of patients with advanced melanoma, the optimal management of locoregional recurrence has not been determined. Various methods are used to treat this group of patients. One of these methods is electrochemotherapy. The [...] Read more.
Background/Objectives: Despite observing progress in recent years in the treatment of patients with advanced melanoma, the optimal management of locoregional recurrence has not been determined. Various methods are used to treat this group of patients. One of these methods is electrochemotherapy. The present study presents the distant results in treating patients with the locoregional recurrence of melanoma, using the technique of electrochemotherapy. Methods: This study includes a retrospective analysis of 88 patients’ data with locoregional melanoma recurrence, treated with electrochemotherapy (ECT) between 2010 and 2023, in two reference centers. Results: Approximately 80% of patients responded to the ECT treatment, achieving partial or complete remission. In a multivariate analysis, statistically significant longer overall survival was found in the group of patients who achieved complete remission after ECT and were treated with immunotherapy. Discussion: The results may suggest the existence of synergy between ECT and immunotherapy. However, confirmation of this fact requires further prospective studies that will also establish the role of ECT in the combination treatment of patients with locoregional recurrence of melanoma. Full article
(This article belongs to the Special Issue Advances in Surgeries for Treating Common Skin Cancers)
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