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Sjogren's Syndrome: Complications and Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 980

Special Issue Editors


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Guest Editor
Rheumatology Clinic, Department of Medical Area, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy
Interests: sjogren’s syndrome; psoriatic arthritis; ultrasonography; rheumatoid arthritis; gout; ostheoarthritis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Rheumatology Clinic, Department of Medical Area, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy
Interests: psoriatic arthritis; psoriasis; rheumatoid arthritis; ultrasonography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Primary Sjögren’s syndrome (pSS) is an autoimmune systemic disease characterized by the destruction of exocrine glands. The lack of saliva and persistent ocular dryness result in increased susceptibility to teeth cavities and corneal damage.

Beyond the dryness discomfort, the systemic nature of pSS implies its potential to impact diverse organs, including the lungs, kidneys, nervous system, and musculoskeletal system. Lymphoma is the most fearable and severe complication, usually localized in the major salivary gland. Parotid swelling is a major predictor of lymphoproliferative disease; therefore, ultrasonographic assessment may provide an early diagnosis, leading to a focused biopsy, contributing to an early diagnosis. Given the wide spectrum of clinical manifestations and complications, disease diagnosis can often be challenging.

From a therapeutic standpoint, there are strategies to alleviate symptoms. At present, local moisturizing treatment can provide relief for dry eyes and mouth, whereas immunosuppressive medications may be prescribed to manage the autoimmune response and reduce inflammation; however, no specific treatment for pSS is currently available.

Considering these challenges, we encourage researchers to submit original research articles and reviews  focusing on the early diagnosis of the disease and its complications. Additionally, contributions related to novel immunomodulatory therapeutic interventions and symptom relief are welcome for submission.

Dr. Ivan Giovannini
Dr. Alen Zabotti
Guest Editors

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Keywords

  • lymphoma
  • ultrasonography
  • core needle biopsy
  • immunosuppressive treatment
  • parotid swelling

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Published Papers (1 paper)

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Research

10 pages, 465 KiB  
Article
Invisible, Uncontrollable, Unpredictable: Illness Experiences in Women with Sjögren Syndrome
by Andrea Herrera, Loreto Leiva, Iris Espinoza, Matías Ríos-Erazo, Nailah Shakhtur, Pamela Wurmann and Gonzalo Rojas-Alcayaga
J. Clin. Med. 2024, 13(11), 3228; https://doi.org/10.3390/jcm13113228 - 30 May 2024
Viewed by 684
Abstract
Background/Objectives: Sjögren’s Syndrome (SS) is a chronic degenerative rheumatic disease. Because of its chronic nature, it significantly affects the quality of life of those who suffer from it. Methods: This qualitative study investigated disease experience among women suffering from SS to [...] Read more.
Background/Objectives: Sjögren’s Syndrome (SS) is a chronic degenerative rheumatic disease. Because of its chronic nature, it significantly affects the quality of life of those who suffer from it. Methods: This qualitative study investigated disease experience among women suffering from SS to understand its impact on their overall well-being. In-depth interviews were conducted with 15 women who suffer from SS. Interviews were analyzed using the Grounded Theory methodology, using open, axial, and selective coding. Results: Three central phenomena of disease experience were identified: invisibility; uncontrollability; and unpredictability. Conclusions: SS disease experience has a strong imprint on emotional well-being and sense of self-control among middle-aged women. Understanding SS impacts on women’s lives is important to better understand the disease and contribute to recognizing potential areas of management and social support in relevant windows of opportunity within the health-disease continuum. Full article
(This article belongs to the Special Issue Sjogren's Syndrome: Complications and Treatment)
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