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Current Advances in Endometriosis: An Update
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Current Advances in Endometriosis: An Update

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 2074

Special Issue Editors

Dr. Mislav Mikuš

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Clinical Hospital Center Zagreb, Zagreb, Croatia
Interests: minimally invasive surgery; endometriosis; adenomyosis
Special Issues, Collections and Topics in MDPI journals
Dr. Mario Ćorić

E-Mail Website
Guest Editor
1. Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, Zagreb, Croatia
2. School of Medicine, University of Zagreb, Zagreb, Croatia
Interests: gynecology and obstetrics; urine incontinence; pelvic floor disorders; lower urinary tract symptom; endometriosis; dysmenorrhea; dyspareunia; yolk sac tumor; dysgerminoma; teratoma
Dr. Antonio Simone Laganà

E-Mail Website
Guest Editor
1. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy
2. Unit of Obstetrics and Gynecology, “Paolo Giaccone” Hospital, 90127 Palermo, Italy
Interests: endometriosis; infertility; minimally invasive surgery; assisted reproduction technology; gynecological endocrinology; reproductive immunology; laparoscopy; hysteroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometriosis is one of the most common gynecological diseases. Despite its benign nature, it is associated with a considerable clinical, social, and financial burden on the healthcare system, mainly due to its undetectability and chronic course. Despite its high prevalence and cost and many published articles, the pathogenesis of endometriosis remains controversial due to a lack of robust evidence. Furthermore, despite current research efforts, diagnosis and treatment options remain difficult.

This Special Issue’s aim is to create a collection of manuscripts that provide an overview of current evidence-based knowledge on endometriosis, covering all important endometriosis and adenomyosis topics, including diagnosis, classification systems, and conservative and surgical therapies for pain and infertility. We also welcome scholars and experts to contribute original research, review articles, or meta-analyses dealing with less common topics, such as endometriosis in adolescence and menopause or outside the pelvis, primary and secondary prevention strategies, new non-invasive diagnostic approaches, or complementary and alternative therapies.

We look forward to receiving your contributions.

Dr. Mislav Mikuš
Dr. Mario Ćorić
Dr. Antonio Simone Laganà
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • gynecological diseases
  • adenomyosis
  • classification
  • diagnosis
  • treatment
  • alternative therapies

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Published Papers (3 papers)

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Research

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11 pages, 584 KiB  
Article
What Will We Learn if We Start Listening to Women with Menses-Related Chest Pain?
by Tomasz Marjanski, Aleksandra Czapla, Julia Niedzielska, Lena Grono, Jagoda Bobula, Renata Świątkowska-Stodulska and Ewa Milnerowicz-Nabzdyk
J. Clin. Med. 2025, 14(9), 2882; https://doi.org/10.3390/jcm14092882 - 22 Apr 2025
Viewed by 203
Abstract
Background. Thoracic endometriosis is thought to be the most common form of endometriosis occurring outside of the pelvis. We aimed to characterize thoracic symptoms of endometriosis in a population of patients not necessarily suffering from catamenial pneumothorax, which is most commonly identified [...] Read more.
Background. Thoracic endometriosis is thought to be the most common form of endometriosis occurring outside of the pelvis. We aimed to characterize thoracic symptoms of endometriosis in a population of patients not necessarily suffering from catamenial pneumothorax, which is most commonly identified as a symptom of thoracic endometriosis. Material and methods. We used a web-based survey addressed to users of two Polish endometriosis patient advocate organizations. The factor that qualified patients for the study was the presence of symptoms in the chest related to the menstrual cycle. Results. A total of 92 respondents were questioned. In this group, 96% (88/92) of patients were previously diagnosed with pelvic endometriosis, 20% (18/92) with thoracic endometriosis, and 18% (17/92) with diaphragmatic endometriosis. The percentage of patients diagnosed with both thoracic and diaphragmatic endometriosis was 15% (14/92). Ninety-eight percent of patients suffered from pain. The four most common symptoms reported by patients were chest pain, dyspnea, cough, and stunned limb, occurring in 96%, 67%, 52%, and 33%, respectively. The feeling of a stunned, weakened limb occurs in older women at 38.4 vs. 35.5 years of age (p = 0.021). There is a trend that women who suffer pain (36.7 vs. 31.3 years of age p = 0.053) and hemoptysis (41.0 vs. 36.2 years of age p = 0.059) are older than women without these symptoms. We identified two unique symptoms of thoracic endometriosis—pouring liquid sensation (13%) and popping sensation (12%)—which can be related to a small amount of gas and fluid in the pleural cavity. Conclusions. Patients who have endometriosis suffer from a constellation of thoracic symptoms related to menses. Full article
(This article belongs to the Special Issue Current Advances in Endometriosis: An Update)
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12 pages, 904 KiB  
Article
The Role of Inflammatory Markers NLR and PLR in Predicting Pelvic Pain in Endometriosis
by Oana Maria Gorun, Adrian Ratiu, Cosmin Citu, Simona Cerbu, Florin Gorun, Zoran Laurentiu Popa, Doru Ciprian Crisan, Marius Forga, Ecaterina Daescu and Andrei Motoc
J. Clin. Med. 2025, 14(1), 149; https://doi.org/10.3390/jcm14010149 - 30 Dec 2024
Cited by 1 | Viewed by 1009
Abstract
Background/Objectives: Chronic inflammation plays a critical role in pelvic pain among endometriosis patients. This study examines the association between inflammatory markers—specifically the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)—and pelvic pain in endometriosis. Methods: We conducted a retrospective analysis of endometriosis [...] Read more.
Background/Objectives: Chronic inflammation plays a critical role in pelvic pain among endometriosis patients. This study examines the association between inflammatory markers—specifically the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)—and pelvic pain in endometriosis. Methods: We conducted a retrospective analysis of endometriosis patients, assessing NLR and PLR levels in those with and without pelvic pain. Diagnostic utility was evaluated using ROC curves, and logistic regression determined associations between these markers, pain presence, and endometriosis severity. Results: Patients with pelvic pain had significantly higher median levels of both NLR and PLR (p < 0.05). NLR demonstrated moderate diagnostic accuracy with an AUC of 0.63, sensitivity of 59%, and specificity of 71% at a cut-off of 1.85. PLR, with a cut-off of 139.77, showed an AUC of 0.60, with a specificity of 82% and sensitivity of 40%, indicating better utility for excluding pain. Logistic regression analysis revealed that NLR > 1.85 was significantly associated with pelvic pain (OR = 3.06, 95% CI: 1.45–6.49, p = 0.003), as was PLR > 139.77 (OR = 2.84, 95% CI: 1.18–6.82, p = 0.02). Advanced rASRM stages (III and IV) also correlated with elevated NLR and PLR values. Conclusions: Elevated NLR and PLR are associated with pelvic pain and advanced stages of endometriosis, suggesting these ratios are potential markers for assessing inflammation and disease severity. Further studies should explore combining NLR and PLR with other biomarkers to improve diagnostic accuracy in endometriosis. Full article
(This article belongs to the Special Issue Current Advances in Endometriosis: An Update)
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Review

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14 pages, 260 KiB  
Review
Analysis of the Biopsychosocial Impacts Associated with Endometriosis to Improve Patient Care
by Aniela Roxana Noditi, Ioana-Stefania Bostan, Francesca Scurtu, Diana Ionescu, Andra Maria Mehedintu, Aida Petca, Claudia Mehedintu, Marinela Bostan and Ana Maria Rotaru
J. Clin. Med. 2025, 14(7), 2158; https://doi.org/10.3390/jcm14072158 - 21 Mar 2025
Viewed by 404
Abstract
Endometriosis is a non-malignant, inflammatory condition that impacts individuals across various hormonal stages, including before their first menstruation, throughout their reproductive years, and after menopause. This condition arises when tissue resembling the uterine lining grows outside the uterus, resulting in inflammation and a [...] Read more.
Endometriosis is a non-malignant, inflammatory condition that impacts individuals across various hormonal stages, including before their first menstruation, throughout their reproductive years, and after menopause. This condition arises when tissue resembling the uterine lining grows outside the uterus, resulting in inflammation and a range of symptoms, such as dysmenorrhea, pain during intercourse, chronic discomfort, and challenges with fertility. This review provides a comprehensive analysis of the medical strategies implemented to address the pathology of endometriosis, highlighting its significant impact on the quality of life of the individuals affected by this condition. Endometriosis can influence various aspects of life, including physical health, emotional well-being, social interactions, and professional performance. Usually, to assess the quality of life in women with endometriosis, validated instruments, such as different questionnaire types, are used to measure the physical, psychological, social, and reproductive health impacts. To improve the quality of life of the women experiencing endometriosis, several supportive strategies are proposed. The findings underscore the necessity of managing endometriosis through a multidisciplinary approach that encompasses both medical and surgical interventions, lifestyle modifications, and psychological support. Full article
(This article belongs to the Special Issue Current Advances in Endometriosis: An Update)
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