Current Advances in Endometriosis: An Update

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 25 March 2025 | Viewed by 793

Special Issue Editors


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Guest Editor
1. Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, Zagreb, Croatia
2. School of Medicine, University of Zagreb, Zagreb, Croatia
Interests: gynecology and obstetrics; urine incontinence; pelvic floor disorders; lower urinary tract symptom; endometriosis; dysmenorrhea; dyspareunia; yolk sac tumor; dysgerminoma; teratoma

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Guest Editor
1. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy
2. Unit of Obstetrics and Gynecology, “Paolo Giaccone” Hospital, 90127 Palermo, Italy
Interests: endometriosis; infertility; minimally invasive surgery; assisted reproduction technology; gynecological endocrinology; reproductive immunology; laparoscopy; hysteroscopy
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Special Issue Information

Dear Colleagues,

Endometriosis is one of the most common gynecological diseases. Despite its benign nature, it is associated with a considerable clinical, social, and financial burden on the healthcare system, mainly due to its undetectability and chronic course. Despite its high prevalence and cost and many published articles, the pathogenesis of endometriosis remains controversial due to a lack of robust evidence. Furthermore, despite current research efforts, diagnosis and treatment options remain difficult.

This Special Issue’s aim is to create a collection of manuscripts that provide an overview of current evidence-based knowledge on endometriosis, covering all important endometriosis and adenomyosis topics, including diagnosis, classification systems, and conservative and surgical therapies for pain and infertility. We also welcome scholars and experts to contribute original research, review articles, or meta-analyses dealing with less common topics, such as endometriosis in adolescence and menopause or outside the pelvis, primary and secondary prevention strategies, new non-invasive diagnostic approaches, or complementary and alternative therapies.

We look forward to receiving your contributions.

Dr. Mislav Mikuš
Dr. Mario Ćorić
Dr. Antonio Simone Laganà
Guest Editors

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Keywords

  • endometriosis
  • gynecological diseases
  • adenomyosis
  • classification
  • diagnosis
  • treatment
  • alternative therapies

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Published Papers (1 paper)

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Research

12 pages, 904 KiB  
Article
The Role of Inflammatory Markers NLR and PLR in Predicting Pelvic Pain in Endometriosis
by Oana Maria Gorun, Adrian Ratiu, Cosmin Citu, Simona Cerbu, Florin Gorun, Zoran Laurentiu Popa, Doru Ciprian Crisan, Marius Forga, Ecaterina Daescu and Andrei Motoc
J. Clin. Med. 2025, 14(1), 149; https://doi.org/10.3390/jcm14010149 - 30 Dec 2024
Cited by 1 | Viewed by 514
Abstract
Background/Objectives: Chronic inflammation plays a critical role in pelvic pain among endometriosis patients. This study examines the association between inflammatory markers—specifically the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)—and pelvic pain in endometriosis. Methods: We conducted a retrospective analysis of endometriosis [...] Read more.
Background/Objectives: Chronic inflammation plays a critical role in pelvic pain among endometriosis patients. This study examines the association between inflammatory markers—specifically the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)—and pelvic pain in endometriosis. Methods: We conducted a retrospective analysis of endometriosis patients, assessing NLR and PLR levels in those with and without pelvic pain. Diagnostic utility was evaluated using ROC curves, and logistic regression determined associations between these markers, pain presence, and endometriosis severity. Results: Patients with pelvic pain had significantly higher median levels of both NLR and PLR (p < 0.05). NLR demonstrated moderate diagnostic accuracy with an AUC of 0.63, sensitivity of 59%, and specificity of 71% at a cut-off of 1.85. PLR, with a cut-off of 139.77, showed an AUC of 0.60, with a specificity of 82% and sensitivity of 40%, indicating better utility for excluding pain. Logistic regression analysis revealed that NLR > 1.85 was significantly associated with pelvic pain (OR = 3.06, 95% CI: 1.45–6.49, p = 0.003), as was PLR > 139.77 (OR = 2.84, 95% CI: 1.18–6.82, p = 0.02). Advanced rASRM stages (III and IV) also correlated with elevated NLR and PLR values. Conclusions: Elevated NLR and PLR are associated with pelvic pain and advanced stages of endometriosis, suggesting these ratios are potential markers for assessing inflammation and disease severity. Further studies should explore combining NLR and PLR with other biomarkers to improve diagnostic accuracy in endometriosis. Full article
(This article belongs to the Special Issue Current Advances in Endometriosis: An Update)
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