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Advances in Spine Disease Research
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Advances in Spine Disease Research

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 25 June 2025 | Viewed by 3841

Special Issue Editor

Dr. Sebastian Głowiński

E-Mail Website
Guest Editor
Institute of Health Sciences, Slupsk Pomeranian University, Westerplatte 64, 76200 Slupsk, Poland
Interests: exoskeletons; spine problems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Spinal disorders and disabilities are among the leading causes of work loss, suffering, and health care expenditure throughout the industrialized world. This Special Issue is focused on the following topics:

  • Degenerative disc disease is a common spinal condition characterized by the breakdown of intervertebral discs. Manuscripts should be focused on understanding the molecular mechanisms underlying disc degeneration, with an emphasis on genetic factors, inflammation, and mechanical stress. Advances in regenerative therapies, such as stem cell treatments and tissue engineering, offer promising avenues for halting or reversing disc degeneration.
  • Spinal stenosis is defined as a narrowing of the spinal canal, leading to compression of the spinal cord and nerves. Manuscripts should concentrate on diagnostic techniques, including advanced imaging methods and biomarkers, to detect and assess the severity of stenosis.
  • Herniated discs occur when the soft inner core of an intervertebral disc protrudes through the outer layer, often causing pain and nerve compression. Manuscripts should focus on minimally invasive surgical techniques, such as endoscopic discectomy, as well as non-surgical options like physical therapy and pain management.
  • Scoliosis is a complex condition characterized by abnormal curvature of the spine. Research should be focused on immunological mechanisms, genetic predisposition, and the development of targeted biologic therapies to manage symptoms and slow disease progression.
  • Spinal cord injury often results in long-term disability. We are interested in research dedicated to finding ways to restore function, e.g., rehabilitation with exoskeleton technology, which hold promise for increasing mobility in paralyzed patients.

I am looking forward to receiving your submission.

Dr. Sebastian Głowiński
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spine diseases
  • low back pain
  • neck back pain
  • spinal biomechanics
  • spine deformity

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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15 pages, 838 KiB  
Article
Association Between Higher Body Mass Index and the Risk of Lumbar Spinal Stenosis in Korean Populations: A Nationwide Cohort Study
by Ji-Hyun Ryu, Kyungdo Han and Ju-Yeong Kim
J. Clin. Med. 2024, 13(23), 7397; https://doi.org/10.3390/jcm13237397 - 4 Dec 2024
Viewed by 476
Abstract
Background/Objectives: Despite the increasing prevalence of both spinal stenosis and obesity, their association remains controversial. This study aimed to investigate the relationship between body mass index (BMI) and the risk of lumbar spinal stenosis in the Korean population using nationwide data. Methods: We [...] Read more.
Background/Objectives: Despite the increasing prevalence of both spinal stenosis and obesity, their association remains controversial. This study aimed to investigate the relationship between body mass index (BMI) and the risk of lumbar spinal stenosis in the Korean population using nationwide data. Methods: We analyzed data from 2,161,684 adults aged ≥40 years who underwent health examinations in 2009 using the Korean National Health Insurance System database. Participants were categorized by BMI into five groups: underweight (<18.5), normal weight (18.5–22.9), overweight (23.0–24.9), obesity class I (25.0–29.9), and obesity class II and above (≥30). Cox proportional hazards models were used to evaluate the association between BMI and lumbar spinal stenosis risk, adjusting for demographic characteristics, lifestyle factors, and comorbidities. Results: During the 10-year follow-up period, the incidence rate of lumbar spinal stenosis increased progressively with higher BMI categories, from 32.77 per 1000 person-years in the underweight group to 51.51 in the obesity class II and above group. In the fully adjusted model, compared to the normal weight group, the hazard ratios (95% confidence intervals) were 0.801 (0.787–0.815) for underweight, 1.132 (1.126–1.139) for overweight, 1.245 (1.238–1.252) for obesity class I, and 1.348 (1.331–1.366) for obesity class II and above. The association was stronger in females and participants aged <65 years. Conclusions: A higher BMI was independently associated with an increased risk of lumbar spinal stenosis in the Korean population. This association remained robust after adjusting for various confounding factors, suggesting BMI as a significant risk factor for spinal stenosis. Full article
(This article belongs to the Special Issue Advances in Spine Disease Research)
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10 pages, 1111 KiB  
Article
Impact of Implant Size and Position on Subsidence Degree after Anterior Cervical Discectomy and Fusion: Radiological and Clinical Analysis
by Adam Bębenek, Maciej Dominiak, Grzegorz Karpiński, Tomasz Pawełczyk and Bartosz Godlewski
J. Clin. Med. 2024, 13(4), 1151; https://doi.org/10.3390/jcm13041151 - 18 Feb 2024
Cited by 1 | Viewed by 1167
Abstract
Background: Implant subsidence is recognized as a complication of interbody stabilization, although its relevance remains ambiguous, particularly in terms of relating the effect of the position and depth of subsidence on the clinical outcome of the procedure. This study aimed to evaluate how [...] Read more.
Background: Implant subsidence is recognized as a complication of interbody stabilization, although its relevance remains ambiguous, particularly in terms of relating the effect of the position and depth of subsidence on the clinical outcome of the procedure. This study aimed to evaluate how implant positioning and size influence the incidence and degree of subsidence and to examine their implications for clinical outcomes. Methods: An observational study of 94 patients (157 levels) who underwent ACDF was conducted. Radiological parameters (implant position, implant height, vertebral body height, segmental height and intervertebral height) were assessed. Clinical outcomes were evaluated using the Visual Analogue Scale (VAS) and Neck Disability Index (NDI). Subsidence was evaluated in groups according to its degree, and statistical analyses were performed. Results: The findings revealed that implant-to-endplate ratio and implant height were significant risk factors associated with the incidence and degree of subsidence. The incidence of subsidence varied as follows: 34 cases (41.5%) exhibited displacement of the implant into the adjacent endplate by 2–3 mm, 32 cases (39%) by 3–4 mm, 16 cases (19.5%) by ≥4 mm and 75 (47.8%) cases exhibited no subsidence. Conclusions: The findings underscore that oversized or undersized implants relative to the disc space or endplate length elevate the risk and severity of subsidence. Full article
(This article belongs to the Special Issue Advances in Spine Disease Research)
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Review

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13 pages, 261 KiB  
Review
Extracorporeal Shock Wave Therapy (eSWT) in Spinal Cord Injury—A Narrative Review
by Józef Opara, Robert Dymarek, Mirosław Sopel and Małgorzata Paprocka-Borowicz
J. Clin. Med. 2024, 13(17), 5112; https://doi.org/10.3390/jcm13175112 - 28 Aug 2024
Viewed by 1657
Abstract
Background: Injury of the spinal cord causes motor and sensory dysfunction as well as pathological reflexes, leading to paraplegia or tetraplegia. The sequelae of traumatic spinal cord injury (SCI) are a significant burden and impact on healthcare systems. Despite constant progress in medicine, [...] Read more.
Background: Injury of the spinal cord causes motor and sensory dysfunction as well as pathological reflexes, leading to paraplegia or tetraplegia. The sequelae of traumatic spinal cord injury (SCI) are a significant burden and impact on healthcare systems. Despite constant progress in medicine, traumatic SCI still remains irreversible. To date, no satisfying treatment that can enable neuronal regeneration and recovery of function at the damaged level has been found. Hundreds of experiments have been conducted on various possibilities of influencing spinal regeneration; some of them have yielded promising results, but unfortunately, the successes obtained in experimental animals have not translated into humans. Methods: This narrative review article presents the application of extracorporeal shock wave therapy (eSWT) in patients with SCI. The article has been divided into parts: 1) use of extracorporeal shock wave therapy for regeneration of the spinal cord after traumatic spinal cord injury; 2) application of extracorporeal shock wave therapy in spasticity after spinal cord injury. In both cases, the hypotheses of possible mechanisms of action will be described. Results and conclusions: A small number of clinical trials have demonstrated the potential of eSWT to influence the regeneration of the spine, as an innovative, safe, and cost-effective treatment option for patients with SCI. Some reports have shown that eSWT can improve spasticity, walking ability, urological function, quality of life, and independence in daily life. Full article
(This article belongs to the Special Issue Advances in Spine Disease Research)
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