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Clinical Updates in Allergic Rhinitis, Asthma and Other Respiratory Allergies
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Clinical Updates in Allergic Rhinitis, Asthma and Other Respiratory Allergies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: closed (15 November 2024) | Viewed by 2734

Special Issue Editors

Prof. Dr. Michele Miraglia del Giudice

E-Mail Website
Guest Editor
Department of Woman, Child and of General and Specialized Surgery. University of Campania ”Luigi Vanvitelli”, Naples, Italy
Interests: respiratory disease; asthma; atopic dermatitis; food and respiratory allergies
Dr. Cristiana Indolfi

E-Mail Website
Guest Editor
Department of Woman, Child and General and Specialized Surgery, University of Campania ‘Luigi Vanvitelli’, 80138 Naples, Italy
Interests: children; asthma; respiratory allergy; food allergy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue aims to navigate the rapidly evolving landscape of allergic respiratory conditions, offering a comprehensive means of exploring recent clinical developments. From innovative diagnostic approaches to emerging therapeutic interventions, the collection addresses key challenges in managing allergic rhinitis, asthma, and related respiratory allergies. As the prevalence of these conditions rises, particularly in children, our Special Issue provides a platform for researchers and clinicians to share cutting-edge insights, bridge knowledge gaps, and enhanced patient care. We invite contributions in the form of original articles or reviews, fostering a collaborative exchange that contributes to the ongoing progress in the field.

Prof. Dr. Michele Miraglia del Giudice
Dr. Cristiana Indolfi
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergic rhinitis
  • asthma
  • respiratory allergies
  • clinical updates
  • interventional therapies
  • allergen immunotherapy
  • biomarkers in allergy
  • children
  • asthma management
  • biological drugs

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Published Papers (2 papers)

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Research

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9 pages, 659 KiB  
Article
Venom Immunotherapy Does Not Affect Survival of Patients with Malignant Tumor in Poland
by Marta Chełmińska, Krzysztof Specjalski, Ewa Jassem, Joanna Polańska, Karolina Kita, Lucyna Górska, Joanna Didkowska, Urszula Wojciechowska, Marita Nittner-Marszalska, Piotr Kuna, Maciej Kupczyk, Jerzy Kruszewski, Aleksander Zakrzewski, Ewa Czarnobilska, Marcin Stobiecki, Rafał Krenke, Andrzej Dąbrowski, Artur Kwaśniewski, Jerzy Jarząb, Andrzej Bożek, Anna Bodzenta-Łukaszyk, Mateusz Łukaszyk, Marek Kowalski, Ewa Smorawska-Sabanty, Andrzej Fal, Katarzyna Przybyłowska, Zbigniew Bartuzi, Krzysztof Pałgan and Marek Niedoszytkoadd Show full author list remove Hide full author list
J. Clin. Med. 2024, 13(11), 3152; https://doi.org/10.3390/jcm13113152 - 28 May 2024
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Abstract
Background: Allergen immunotherapy (AIT) is a well-established and efficient method of causative treatment for allergic rhinitis, asthma and insect venom allergy. Traditionally, a recent history of malignant neoplasm is regarded as a contraindication to AIT due to concerns that AIT might stimulate tumor [...] Read more.
Background: Allergen immunotherapy (AIT) is a well-established and efficient method of causative treatment for allergic rhinitis, asthma and insect venom allergy. Traditionally, a recent history of malignant neoplasm is regarded as a contraindication to AIT due to concerns that AIT might stimulate tumor growth. However, there are no data confirming that the silencing of the Th2 response affects prognosis in cancer. Objectives: The aim of this study was to investigate frequency of malignant tumors in patients undergoing AIT and the association between AIT and cancer-related mortality. Patients and Methods: A group of 2577 patients with insect venom allergy undergoing AIT in 10 Polish allergology centers was screened in the Polish National Cancer Registry. Data on cancer type, diagnosis time and patients’ survival were collected and compared with the general population. Results: In the study group, 86 cases of malignancies were found in 85 patients (3.3% of the group). The most common were breast (19 cases), lung (9 cases), skin (8 cases), colon and prostate cancers (5 cases each). There were 21 cases diagnosed before AIT, 38 during and 27 after completing AIT. Laplace’s crude incidence rate was 159.5/100,000/year (general population rate: 260/100,000/year). During follow-up, 13 deaths related to cancer were revealed (15% of patients with cancer). Laplace’s cancer mortality rate was 37.3/100,000/year (general population rate: 136.8/100,000/year). Conclusions: Malignancy was found in patients undergoing immunotherapy less often than in the general population. Patients with cancer diagnosed during or after AIT did not show a lower survival rate, which suggests that AIT does not affect the prognosis. Full article
(This article belongs to the Special Issue Clinical Updates in Allergic Rhinitis, Asthma and Other Respiratory Allergies)
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Review

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14 pages, 1948 KiB  
Review
A Modern Approach to Clinical Outcome Assessment in Allergy Management: Advantages of Allergen Exposure Chambers
by Magdalena Zemelka-Wiacek
J. Clin. Med. 2024, 13(23), 7268; https://doi.org/10.3390/jcm13237268 - 29 Nov 2024
Viewed by 836
Abstract
Allergic diseases triggered by airborne allergens such as allergic rhinitis and conjunctivitis are increasingly prevalent, posing significant challenges for both patients and healthcare systems. Assessing the efficacy of allergen immunotherapy and other anti-allergic treatments requires precise and reproducible methods. Allergen exposure chambers (AECs) [...] Read more.
Allergic diseases triggered by airborne allergens such as allergic rhinitis and conjunctivitis are increasingly prevalent, posing significant challenges for both patients and healthcare systems. Assessing the efficacy of allergen immunotherapy and other anti-allergic treatments requires precise and reproducible methods. Allergen exposure chambers (AECs) have emerged as advanced tools for evaluating clinical outcomes, offering controlled conditions that address many limitations of traditional field-based studies. This review explores the advantages of AECs in allergy management, emphasizing their role in providing standardized allergen exposure for both clinical research and routine assessments. AECs deliver consistent and reproducible data comparable to the nasal allergen challenge and natural allergen exposure, making them a valuable addition to the diagnosis and treatment effectiveness of allergic diseases. Although they are well suited to early-stage clinical trials, further standardization and validation are needed to gain broader acceptance in pivotal phase III studies. Future research should focus on refining AEC protocols and integrating them into regulatory frameworks, ensuring their role in the advancement of therapeutic approaches for allergic diseases. Full article
(This article belongs to the Special Issue Clinical Updates in Allergic Rhinitis, Asthma and Other Respiratory Allergies)
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