Aphasia in Vascular and Degenerative Conditions: From Theory to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (1 April 2022) | Viewed by 18437

Special Issue Editors


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Guest Editor
Unit of Cognitive Neurology and Aphasia, Centro de Investigaciones Médico-Sanitarias, University of Malaga, 29010 Malaga, Spain
Interests: post-stroke aphasia; primary progressive aphasia; aphasia in degenerative disorders; neuropsychiatric-associated disorders; neuroimaging; neurophysiology; biological markers; computer modeling; eye tracking; predictors of recovery; outcome measures; aphasia therapy; pharmacotherapy; non-invasive brain stimulation

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Co-Guest Editor
Research Laboratory on the Neuroscience of Language, Faculty of Psychology and SpeechTherapy, University of Malaga, Malaga, Spain
Interests: post-stroke aphasia; primary progressive aphasia; aphasia in degenerative disorders; neuropsychiatric-associated disorders; neuroimaging; neurophysiology; biological markers; computer modeling; eye tracking; predictors of recovery; outcome measures; aphasia therapy; pharmacotherapy; non-invasive brain stimulation

E-Mail Website
Co-Guest Editor
Research Laboratory on the Neuroscience of Language, Faculty of Psychology and SpeechTherapy, University of Malaga, Malaga, Spain
Interests: post-stroke aphasia; primary progressive aphasia; aphasia in degenerative disorders; neuropsychiatric-associated disorders; neuroimaging; neurophysiology; biological markers; computer modeling; eye tracking; predictors of recovery; outcome measures; aphasia therapy; pharmacotherapy; non-invasive brain stimulation

Special Issue Information

Dear Colleagues,

Aphasia is a leading cause of disability and poor life quality in populations with stroke and neurodegenerative conditions. This disorder is multidimensional, affecting non-language domains and behavior (motivation, mood). In the last few decades, great advances have been achieved in understanding the neurobiology of language and in the diagnosis and treatment of aphasia. For example, research aiming to find biomarkers (behavioral profiles, genetic testing and neuroimaging) that aid prediction of aphasia recovery and/or treatment response is growing. Moreover, deficits in non-linguistic domains such as executive and attention functions, resulting from damage to widely distributed brain networks, can predict certain aspects of language recovery or treatment outcomes. Advances in the treatment of aphasia are also being obtained by applying neuroscience-based therapies used alone and in combination with pharmacological agents and non-invasive brain stimulation that heighten experience-dependent plasticity.

This Special Issue focuses on recent advances in aphasia spanning from theory to treatment. We are seeking publications covering the following topics: post-stroke aphasia, primary progressive aphasia, aphasia in degenerative disorders, neuropsychiatric disorders associated with aphasia, and studies of neuroimaging, neurophysiology, computer modeling, biomarkers, eye tracking, predictors of recovery, outcome measures, language rehabilitation, pharmacotherapy, and non-invasive brain stimulation applied aphasia.

Prof. Dr. Marcelo L. Berthier
Prof. Dr. Guadalupe Dávila
Dr. Diana Lopez-Barroso
Guest Editors

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Keywords

  • Post-stroke aphasia
  • Primary progressive aphasia
  • Aphasia therapy
  • Pharmacotherapy
  • Non-invasive brain stimulation

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Published Papers (2 papers)

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Review

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23 pages, 612 KiB  
Review
Novel Advances to Post-Stroke Aphasia Pharmacology and Rehabilitation
by Natalia Cichon, Lidia Wlodarczyk, Joanna Saluk-Bijak, Michal Bijak, Justyna Redlicka, Leslaw Gorniak and Elzbieta Miller
J. Clin. Med. 2021, 10(17), 3778; https://doi.org/10.3390/jcm10173778 - 24 Aug 2021
Cited by 28 | Viewed by 11925
Abstract
Aphasia is one of the most common clinical features of functional impairment after a stroke. Approximately 21–40% of stroke patients sustain permanent aphasia, which progressively worsens one’s quality of life and rehabilitation outcomes. Post-stroke aphasia treatment strategies include speech language therapies, cognitive neurorehabilitation, [...] Read more.
Aphasia is one of the most common clinical features of functional impairment after a stroke. Approximately 21–40% of stroke patients sustain permanent aphasia, which progressively worsens one’s quality of life and rehabilitation outcomes. Post-stroke aphasia treatment strategies include speech language therapies, cognitive neurorehabilitation, telerehabilitation, computer-based management, experimental pharmacotherapy, and physical medicine. This review focuses on current evidence of the effectiveness of impairment-based aphasia therapies and communication-based therapies (as well as the timing and optimal treatment intensities for these interventions). Moreover, we present specific interventions, such as constraint-induced aphasia therapy (CIAT) and melodic intonation therapy (MIT). Accumulated data suggest that using transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) is safe and can be used to modulate cortical excitability. Therefore, we review clinical studies that present TMS and tDCS as (possible) promising therapies in speech and language recovery, stimulating neuroplasticity. Several drugs have been used in aphasia pharmacotherapy, but evidence from clinical studies suggest that only nootropic agents, donepezil and memantine, may improve the prognosis of aphasia. This article is an overview on the current state of knowledge related to post-stroke aphasia pharmacology, rehabilitation, and future trends. Full article
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12 pages, 411 KiB  
Systematic Review
Melodic Intonation Therapy in Post-Stroke Non-Fluent Aphasia and Its Effects on Brain Plasticity
by Natalia García-Casares, Amanda Barros-Cano and Juan A. García-Arnés
J. Clin. Med. 2022, 11(12), 3503; https://doi.org/10.3390/jcm11123503 - 17 Jun 2022
Cited by 7 | Viewed by 5795
Abstract
Melodic Intonation Therapy (MIT) is one of the most well-known therapies for the rehabilitation of speech in patients with non-fluent aphasia and which is thought to promote right-hemisphere involvement in language processing. This review focuses on the study of language lateralization and/or neuroplastic [...] Read more.
Melodic Intonation Therapy (MIT) is one of the most well-known therapies for the rehabilitation of speech in patients with non-fluent aphasia and which is thought to promote right-hemisphere involvement in language processing. This review focuses on the study of language lateralization and/or neuroplastic reorganization with neuroimaging and/or neurophysiological techniques in non-fluent aphasic patients post-stroke during or after MIT. A systematic search was carried out according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) in databases (PubMed, Scopus, EMBASE, Dialnet, Web of Science, Cochrane) with the keywords melodic intonation therapy, neuroimaging, functional magnetic resonance, and positron emission tomography and the boolean operators AND and OR. Articles including patients of all ages and either sex with any type of aphasia post-stroke and in any language, which studied language lateralization and/or neuroplastic reorganization after or during MIT were included. Articles which did not achieve the objectives, revisions and conferences were excluded. Different results were obtained from the 16 studies included in the review: predominantly greater activation of the right hemisphere but also of the left hemisphere or both. MIT is an effective therapy to rehabilitate non-fluent aphasic patients post-stroke. It involves different neurobiological mechanisms and depends on multiple individual factors. Studies with larger samples are necessary. Full article
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