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Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II
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Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 3387

Special Issue Editor

Prof. Dr. Izumi Asahina

E-Mail Website
Guest Editor
Department of Dentistry and Oral Surgery, Juntendo Hospital, 3-1-3 Hongo, Bunkyo‑ku, Tokyo 113‑8421, Japan
Interests: regenerative dentistry; bone tissue engineering; stem cell therapy; gene-activated matrix; implant dentistry; orthognathic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

An understanding of a wide range of bone regeneration, from periodontal defects to jawbone deficiency, is required in the daily practice of dentistry and oral and maxillofacial surgery. In particular, demands for bone regeneration are increasing due to the advancement of aging in our society. Autogenous bone grafts are still widely used as the gold standard because of their superior osteogenecity, though it has disadvantages such as limited availability and donor-site morbidity. However, recent advancements in material sciences and stem cell biology enable us to develop new strategies to regenerate bone deficiencies in the oral and maxillofacial regions. Thus, many clinical studies using new biomaterials, biological molecules, and/or stem cells have been conducted.

This Special Issue is intended to provide an overview of the recent advances in bone regeneration in dentistry and oral and maxillofacial surgery, and to give readers an idea of the strategies to standardize bone regeneration in the next era. The first part of this Special Issue has been successfully published. Now, we plan to publish a second part in response to the interests both from readers and authors.

On behalf of the Journal of Clinical Medicine, you are cordially invited to contribute an article to the Special Issue, “Bone Regeneration in Dentistry and Oral and Maxillofacial Surgery: Part II.” Research articles and reviews are welcome.

Prof. Dr. Izumi Asahina
Guest Editor

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • alveolar bone regeneration
  • jawbone reconstruction
  • clinical trial
  • biomaterials
  • tissue engineering
  • stem cells

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Published Papers (4 papers)

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Research

12 pages, 1317 KiB  
Article
Utilization of a Cortical Xenogeneic Membrane for Guided Bone Regeneration: A Retrospective Case Series
by Cyril Debortoli, Arthur Falguiere, Fabrice Campana, Jean-Hugues Catherine, Delphine Tardivo and Romain Lan
J. Clin. Med. 2024, 13(15), 4575; https://doi.org/10.3390/jcm13154575 - 5 Aug 2024
Viewed by 396
Abstract
Background: Guided bone regeneration (GBR) is a reliable technique used in vertical and horizontal bone defects. The posterior mandibular region is an area limited by anatomic constraints. The use of resorbable membranes with a cortical component could compensate for the lack of [...] Read more.
Background: Guided bone regeneration (GBR) is a reliable technique used in vertical and horizontal bone defects. The posterior mandibular region is an area limited by anatomic constraints. The use of resorbable membranes with a cortical component could compensate for the lack of rigidity of resorbable membranes without the complications of non-resorbable membranes. The aim of this study was to evaluate the mean bone gains of a xenogeneic cortical membrane in horizontal and vertical bone defects in comparison with other membranes in the literature. Methods: A porcine cortical membrane was used to perform 7 GBR in the posterior mandibular region of five patients. Preoperative (T0) and six months postoperative (T1) cone beam computed tomography were superimposed to measure the horizontal and vertical bone gain. Implants were positioned at all sites, six months after GBR. Complications and bone resorption around the implants were also documented. Results: The mean horizontal and vertical bone gains were 3.83 ± 1.41 mm and 4.17 ± 1.86 mm, respectively. The analysis of repeatability was 0.997. As many as 40% of patients experienced pain refractory to analgesics. No exposure or infectious phenomenon was observed. Conclusions: This xenogeneic cortical membrane seemed to provide interesting results in the regeneration of horizontal and vertical bone defects. Comparative and prospective studies are necessary to validate the effectiveness of this membrane. Full article
(This article belongs to the Special Issue Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II)
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18 pages, 5221 KiB  
Article
Tooth Autotransplantation, Autogenous Dentin Graft, and Growth Factors Application: A Method for Preserving the Alveolar Ridge in Cases of Severe Infraocclusion—A Case Report and Literature Review
by Paulina Adamska, Dorota Pylińska-Dąbrowska, Marcin Stasiak, Hanna Sobczak-Zagalska, Antoni Jusyk, Adam Zedler and Michał Studniarek
J. Clin. Med. 2024, 13(13), 3902; https://doi.org/10.3390/jcm13133902 - 3 Jul 2024
Viewed by 712
Abstract
Background: Tooth infraocclusion is a process in which a completely or partially erupted tooth gradually moves away from the occlusal plane. Submerged teeth can lead to serious complications. Treating teeth with infraocclusion is very challenging. One of the procedures allowing for the [...] Read more.
Background: Tooth infraocclusion is a process in which a completely or partially erupted tooth gradually moves away from the occlusal plane. Submerged teeth can lead to serious complications. Treating teeth with infraocclusion is very challenging. One of the procedures allowing for the replacement of a missing tooth is autotransplantation. The aim of this paper is to review the literature on teeth autotransplantation, supported by a case report involving the autotransplantation of a third mandibular molar into the site of an extracted infraoccluded first mandibular molar, as well as the utilization of advanced platelet-rich fibrin (A-PRF) alongside autogenous dentin grafts for bone tissue regeneration. Methods: A severely infraoccluded first permanent right mandibular molar was extracted and then ground to obtain the dentin graft. A-PRF clots (collected from the patient’s peripheral blood) were added to the autogenous dentin graft, to create the A-PRF membrane. An atraumatic extraction of the lower left third molar was performed and then it was transplanted into the socket of tooth no. 46. Immediately after transplantation, tooth no. 38 was stabilized with orthodontic bracket splints for 3 months. The patient attended regular follow-up visits within 12 months. Results: After one year, the patient did not report any pain. In the clinical examination, the tooth and surrounding tissues did not show any signs of infection. However, radiographically, cervical inflammatory resorption, unchanged pulp canal dimensions, absent root growth, periapical radiolucency, and lack of apical and marginal healing were observed. Reconstruction of the bone defect was obtained and the alveolar ridge of the mandible was preserved. Due to poor stability of the tooth and severe resorption, the tooth needed to be extracted. Conclusions: This study is designed to critically evaluate the efficacy of autotransplantation, the application of growth factors, and the integration of autogenous dentin grafts in remedying dental deficiencies resulting from reinclusion. We aim to point out the possible causes of treatment failure. Full article
(This article belongs to the Special Issue Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II)
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10 pages, 1501 KiB  
Article
A Prospective Study of the Assessment of the Efficacy of a Biodegradable Poly(l-lactic acid/ε-caprolactone) Membrane for Guided Bone Regeneration
by Rena Shido, Seigo Ohba, Risa Tominaga, Yoshinori Sumita and Izumi Asahina
J. Clin. Med. 2023, 12(18), 5994; https://doi.org/10.3390/jcm12185994 - 15 Sep 2023
Viewed by 881
Abstract
Biodegradable guided bone regeneration (GBR) membranes consist primarily of collagen and aliphatic polyesters. This study assessed the comparative efficacy of a poly(l-lactic-caprolactone) [P(LA/CL)] membrane versus that of a collagen membrane in GBR. Patients requiring GBR simultaneously or before dental implant placement [...] Read more.
Biodegradable guided bone regeneration (GBR) membranes consist primarily of collagen and aliphatic polyesters. This study assessed the comparative efficacy of a poly(l-lactic-caprolactone) [P(LA/CL)] membrane versus that of a collagen membrane in GBR. Patients requiring GBR simultaneously or before dental implant placement in edentulous regions were randomly assigned to one of two membranes. Within each membrane, they were subdivided into 3 groups: dental implants were placed simultaneously with GBR in groups A and B, and 180 days post-GBR in group C. The augmented bone width was measured at 1, 3, and 6 mm from the implant’s neck (groups A and B) or the reference line (group C), utilizing cone-beam computed tomography images, immediately and 150 days post-surgery. A histological study was performed to evaluate bone formation in group C. No adverse events were observed. In the collagen group, the absorbed ratios of the augmented bone were 40.9 ± 36.7%, 29.4 ± 30.1%, and 11.1 ± 22.0% at 1, 3, and 6 mm, respectively; the ratio at 6 mm was significantly lower than that at 1 mm (p = 0.0442). In the P(LA/CL) group, those were 26.2 ± 27.3%, 17.1 ± 19.7%, and 13.3 ± 16.4% at 1, 3, and 6 mm, respectively, with no significant difference at each point. No significant inter-membrane differences were observed. The bone augmentation potential of the P(LA/CL) membrane matched that of the collagen membrane. P(LA/CL) could be used as a safe and effective membrane in GBR. Full article
(This article belongs to the Special Issue Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II)
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11 pages, 2880 KiB  
Article
Biomolecular Mechanisms and Case Series Study of Socket Preservation with Tooth Grafts
by Elio Minetti, Gianna Dipalma, Andrea Palermo, Assunta Patano, Alessio Danilo Inchingolo, Angelo Michele Inchingolo and Francesco Inchingolo
J. Clin. Med. 2023, 12(17), 5611; https://doi.org/10.3390/jcm12175611 - 28 Aug 2023
Cited by 2 | Viewed by 893
Abstract
The purpose of this research was to assess the effectiveness of an innovative medical device capable of extracting tooth graft materials directly from the patient’s own teeth. Twenty consecutive tooth grafting procedures were conducted, with an average follow-up period of 18 months. Methods: [...] Read more.
The purpose of this research was to assess the effectiveness of an innovative medical device capable of extracting tooth graft materials directly from the patient’s own teeth. Twenty consecutive tooth grafting procedures were conducted, with an average follow-up period of 18 months. Methods: Twenty patients requiring tooth extraction underwent socket preservation utilizing the extracted tooth as the grafting material. Results: After a 4-month healing period, the defects were significantly filled with newly formed hard tissue. Subsequently, bone biopsies were performed during dental implant placement to evaluate histological outcomes. The tissue exhibited a similar density to medium-density bone, displaying a homogeneous and uniform appearance without any visible signs of inflammation. The post-operative healing phase was free from infective complications or indications of graft particles within the regenerated bone structure. The histomorphometric analyses revealed the following results: bone total volume, BV% 52.6 ± 13.09, vital bone VB% 40.39 ± 15.86, residual graft % 12.20 ± 12.34. Conclusion: The study demonstrated positive bony healing in guided regenerative surgery procedures using autologous tooth grafts. However, further research with an extended follow-up period is necessary to thoroughly assess the potential of demineralized dentin autografts. Full article
(This article belongs to the Special Issue Bone Regeneration in Dentistry, Oral and Maxillofacial Surgery: Part II)
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