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Clinical Advances in Angina Pectoris
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Clinical Advances in Angina Pectoris

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (18 May 2024) | Viewed by 6260

Special Issue Editors

Dr. Carlo Zivelonghi

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Guest Editor
Hartcentrum ZNA, Middelheim, Antwerp, Belgium
Interests: PCI; CTO PCI; intracoronary physiology; refractory angina; complex PCI; CHIP
Dr. Valeria Paradies

E-Mail Website
Guest Editor
Maasstad Hospital, Rotterdam, The Netherlands
Interests: percutaneous coronary intervention; intravascular imaging and physiology; microvascular dysfunction; CHIP

Special Issue Information

Dear Colleagues,

Angina pectoris is a chronic disabling condition affecting a growing number of patients with ischemic heart disease. It becomes refractory when complaints persist despite optimal medical therapy due to severe and/or diffuse coronary artery disease (CAD) without options for percutaneous or surgical revascularization procedures. Furthermore, a growing proportion of patients complaining of angina pectoris appear to suffer from microvascular dysfunction without obstructive coronary artery disease. The recent progress in the diagnosis and treatment of this condition represents for the clinical and interventional cardiologist an opportunity to further improve the identification of the affected patients and their clinical outcome.

The availability of advanced physiology measurements allows us not only to better identify patients with epicardial and microvascular disease, but also to guide the cardiologist to the best treatment option. Similarly, the continuous improvements in materials and techniques for complex revascularisation procedures (such as Chronic Total Occlusions) allow for not only an extremely high success rate, but also for a less invasive approach and potentially reduced complications rate. Finally, a recently introduced device for the treatment of refractory angina (such as the Coronary Sinus Reducer) may provide additional tools when revascularisation procedures and physiology-guided optimal medical therapy are not sufficiently effective. In this Special Issue, we welcome authors to submit papers on the clinical advance of refractory angina as well as angina without obstructive coronary artery disease in terms of both diagnosis and treatment.

Dr. Carlo Zivelonghi
Dr. Valeria Paradies
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • angina pectoris
  • refractory angina
  • chronic total occlusion
  • microvascular dysfunction
  • intracoronary physiology
  • coronary sinus reducer

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Published Papers (4 papers)

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Research

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9 pages, 210 KiB  
Article
Safety and Effectiveness of Coronary Sinus Reducer in the Therapy of Refractory Angina Pectoris—Mid-Term Results of the Real-Life Cohort
by Szymon Włodarczak, Piotr Rola, Artur Jastrzębski, Karol Turkiewicz, Andrzej Korda, Piotr Włodarczak, Mateusz Barycki, Jan Jakub Kulczycki, Łukasz Furtan, Adrian Włodarczak and Maciej Lesiak
J. Clin. Med. 2024, 13(15), 4413; https://doi.org/10.3390/jcm13154413 - 28 Jul 2024
Viewed by 818
Abstract
Background: Despite continuous improvements in revascularization techniques, refractory angina without potential revascularization options remains a relevant clinical issue with significant impact on the patient’s quality of life. Recently, a novel device, the Coronary Sinus Reducer (CSR), has been introduced into clinical practice as [...] Read more.
Background: Despite continuous improvements in revascularization techniques, refractory angina without potential revascularization options remains a relevant clinical issue with significant impact on the patient’s quality of life. Recently, a novel device, the Coronary Sinus Reducer (CSR), has been introduced into clinical practice as a therapeutic option for patients with disabling angina pectoris. In this single-center, observational study, we evaluated the mid-term (3-month) safety and efficacy of the CSR in a real-world cohort. Methods: The study population consisted of 55 patients with refractory angina without potential revascularization options, who were predominantly men (87.3%) with a high cardiovascular risk factor burden and advanced angina (baseline CCS angina class 3.15 ± 0.6). In terms of procedure safety, all patients underwent successful device deployment with only one periprocedural complication. Results: At the 3-month follow-up, we observed a statistically significant improvement in angina control measured CCS class and SAQ-7 total questionnaire along with increased abolition of physical limitation—6-MWT (233.3 ± 107.1 vs. 305.2 ± 126.8; p < 0.0001). Additionally, we observed significant improvement in terms of quality of life measurements SF-36, the EQ-5D-5L questionnaire, and the EQ-VAS. Conclusions: Our real-world data suggest that CSR implantation is a relatively safe procedure and appears to be particularly effective in relieving angina symptoms and improving quality of life in subjects with refractory angina. Full article
(This article belongs to the Special Issue Clinical Advances in Angina Pectoris)

Review

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34 pages, 1998 KiB  
Review
Clinical Updates in Coronary Artery Disease: A Comprehensive Review
by Andrea Bottardi, Guy F. A. Prado, Mattia Lunardi, Simone Fezzi, Gabriele Pesarini, Domenico Tavella, Roberto Scarsini and Flavio Ribichini
J. Clin. Med. 2024, 13(16), 4600; https://doi.org/10.3390/jcm13164600 - 6 Aug 2024
Viewed by 694
Abstract
Despite significant goals achieved in diagnosis and treatment in recent decades, coronary artery disease (CAD) remains a high mortality entity and continues to pose substantial challenges to healthcare systems globally. After the latest guidelines, novel data have emerged and have not been yet [...] Read more.
Despite significant goals achieved in diagnosis and treatment in recent decades, coronary artery disease (CAD) remains a high mortality entity and continues to pose substantial challenges to healthcare systems globally. After the latest guidelines, novel data have emerged and have not been yet considered for routine practice. The scope of this review is to go beyond the guidelines, providing insights into the most recent clinical updates in CAD, focusing on non-invasive diagnostic techniques, risk stratification, medical management and interventional therapies in the acute and stable scenarios. Highlighting and synthesizing the latest developments in these areas, this review aims to contribute to the understanding and management of CAD helping healthcare providers worldwide. Full article
(This article belongs to the Special Issue Clinical Advances in Angina Pectoris)
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18 pages, 9112 KiB  
Review
Coronary Vascular (DYS) Function and Invasive Physiology Assessment: Insights into Bolus and Continuous Thermodilution Methods
by Matteo Maurina, Alice Benedetti, Giulio Stefanini, Gianluigi Condorelli, Carlos Collet, Carlo Zivelonghi, Pieter C. Smits and Valeria Paradies
J. Clin. Med. 2023, 12(14), 4864; https://doi.org/10.3390/jcm12144864 - 24 Jul 2023
Cited by 1 | Viewed by 2115
Abstract
A considerable number of patients with angina or myocardial ischemia have no significant coronary artery disease on invasive angiography. In recent years, several steps towards a better comprehension of the pathophysiology of these conditions, angina or ischemia with non-obstructive coronary arteries (ANOCA/INOCA), have [...] Read more.
A considerable number of patients with angina or myocardial ischemia have no significant coronary artery disease on invasive angiography. In recent years, several steps towards a better comprehension of the pathophysiology of these conditions, angina or ischemia with non-obstructive coronary arteries (ANOCA/INOCA), have been made. Nevertheless, several gaps in knowledge still remain. This review is intended to provide a comprehensive overview of ANOCA and INOCA, with a particular focus on pathophysiology, recent diagnostic innovations, gaps in knowledge and treatment modalities. Full article
(This article belongs to the Special Issue Clinical Advances in Angina Pectoris)
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22 pages, 5401 KiB  
Review
Percutaneous Coronary Intervention for Chronic Total Occlusion—Contemporary Approach and Future Directions
by Emil Julian Dąbrowski, Michał Święczkowski, Joanna Maria Dudzik, Oliwia Grunwald, Tomasz Januszko, Paweł Muszyński, Piotr Pogorzelski, Justyna Tokarewicz, Maciej Południewski, Marcin Kożuch and Sławomir Dobrzycki
J. Clin. Med. 2023, 12(11), 3762; https://doi.org/10.3390/jcm12113762 - 30 May 2023
Cited by 1 | Viewed by 1962
Abstract
In the aging society, the issue of coronary chronic total occlusion (CTO) has become a challenge for invasive cardiologists. Despite the lack of clear indications in European and American guidelines, the rates of percutaneous coronary interventions (PCI) for CTO increased over the last [...] Read more.
In the aging society, the issue of coronary chronic total occlusion (CTO) has become a challenge for invasive cardiologists. Despite the lack of clear indications in European and American guidelines, the rates of percutaneous coronary interventions (PCI) for CTO increased over the last years. Well-conducted randomized clinical trials (RCT) and large observational studies brought significant and substantial progress in many CTO blind spots. However, the results regarding the rationale behind revascularization and the long-term benefit of CTO are inconclusive. Knowing the uncertainties regarding PCI CTO, our work sought to sum up and provide a comprehensive review of the latest evidence on percutaneous recanalization of coronary artery chronic total occlusion. Full article
(This article belongs to the Special Issue Clinical Advances in Angina Pectoris)
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