Obsessive Compulsive Disorder: Clinical Advances and Future Perspectives

Dear Colleagues,

Obsessive compulsive disorder (OCD) is a complex and often debilitating mental disorder characterized by persistent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions) performed to relieve distress. Despite significant advances in the understanding of OCD, many aspects of its etiology, pathophysiology, and treatment remain unclear. This Special Issue aims to consolidate the latest research and clinical findings on OCD and to promote a comprehensive understanding of the disorder.

We invite contributions that explore neurobiological underpinnings, genetic and environmental influences, and innovative therapeutic interventions. In addition, we welcome studies on the impact of comorbid conditions, advances in diagnostic criteria, and the development of novel treatment modalities.

A major focus of this Special Issue will be on personalized treatment pathways for OCD, emphasizing the progression from initial treatment strategies to the management of the most resistant presentations of the disorder. We seek research on tailored therapeutic approaches, including cognitive–behavioral therapy (CBT), pharmacotherapy, and emerging treatments such as neuromodulation techniques. Papers that discuss treatment selection criteria, strategies for improving treatment adherence, and methods for optimizing outcomes in resistant-OCD cases are particularly encouraged.

We also encourage submissions that explore the phenomenology of OCD, examining the diverse manifestations and subjective experiences of the disorder. Understanding the different ways in which OCD presents and affects individuals may lead to more effective and empathetic treatment approaches.

In addition, this Special Issue invites research on the application of artificial intelligence (AI) to the study and treatment of OCD. We are interested in how AI can be used to analyze large datasets to gain new insights into the disorder, predict treatment response, and help select the most effective interventions for individual patients. Papers discussing AI-driven diagnostic tools, personalized treatment algorithms, and predictive models of treatment outcomes are highly encouraged.

By bringing together a diverse range of high-quality research works, this Special Issue aims to advance our knowledge of OCD, promote evidence-based practice, and ultimately improve outcomes for individuals affected by this challenging disorder.

Prof. Dr. Andrea Fagiolini
Guest Editor

Manuscript Submission Information

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• obsessions–compulsions
• anxiety
• OCD symptoms
• treatment options
• functional impairment