Clinical Insights on Cross-Talk between Tissues/Organs in the Setting of Metabolic Diseases
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 31917
Special Issue Editors
2. Portuguese Diabetes Association - Education and Research Center (APDP-ERC), Lisbon, Portugal
3. Department of Medical Sciences, University of Aveiro, Aveiro, Portugal
Interests: prediabetes; diabetes; obesity; autonomic dysfunction; insulin resistance; insulin clearance; non-alcoholic fatty liver disease; metabolic associated liver disease; fibrosis; gut-liver cross talk; brain-liver cross talk; translational research; clinical research
2. Portuguese Diabetes Association - Education and Research Center (APDP-ERC), Lisbon, Portugal
Interests: metabolic flux analysis; noninvasive measurements of hepatic stable-isotope tracer metabolism; intermediary metabolism; type 1 and type 2 diabetes; fatty liver disease; rare metabolic diseases
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Special Issue Information
Dear Colleagues,
Some of the most prevalent metabolic diseases today, including Type 2 diabetes and non-alcoholic fatty liver disease, involve altered or disrupted communication between different tissues and/or organs. The communication modes include signaling events transmitted by endocrine hormones, cytokines, neurons, metabolites, and exosomes and can involve both constitutive tissues and commensal microbiota. Identifying and characterizing these processes in the clinical setting requires integrating hitherto unconnected disciplines and diagnostic methods: for example, imaging of liver fat and fibrosis with the characterization of intestinal microbiome activity to understand the role of intestinal dysbiosis in driving fatty liver disease.
This Special Issue of the Journal of Clinical Medicine will report new advances in the integration of epidemiology, natural history, and novel pathogenic mechanisms that enhance our understanding of biological cross-talk in disease settings with a strong focus on those measurements and methodologies that can be applied in the clinical setting. The implication of tissue cross-talk processes in clinical diagnosis and treatment will also be highlighted. Therefore, researchers in the area of metabolic diseases are welcome to submit original research articles, meta-analyses, or reviews to this Special Issue.
Prof. Paula M. Macedo
Prof. John Jones
Guest Editors
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Keywords
- Noninvasive methods of diagnosis
- Oxidative stress in metabolic organs
- Lipotoxicity
- Cell death mechanisms
- Inflammation
- Insulin Resistance
- Organs Cross talk
- Pancreas-liver axis
- Gut-liver axis
- Brain-liver axis
- Glucidic and lipid metabolism
- Metabolic organs dysfunction at the basis of risk factors for cardiovascular diseases
- Fibrogenesis
- In vitro/in vivo models of metabolic organs
- Epidemiological aspects
- Natural history of dysmetabolism
- Emerging medical therapies
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