Diagnosis, Molecular Pathogenesis, and Targeted Therapies for Cholangiocarcinoma
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 14697
Special Issue Editor
Interests: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; hepatoblastoma; mouse models; cancer genetics and epigenetics; signal transduction; cancer metabolism; precision medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cholangiocarcinoma (CCA) is a highly lethal disease with few therapeutic options and rising incidence. The prognosis is generally poor, mainly due to the diagnosis of the disease at an advanced, inoperable stage. Thus, early markers of CCA should be identified and characterized for rapid detection and surgical removal of the tumor. Nonetheless, even when the tumor can be completely resected, often patients experience recurrence. Therefore, novel and effective therapies (possibly individualized) are urgently needed to significantly improve the prognosis of CCA patients. For this purpose, a deeper understanding of the molecular mechanisms involved in CCA development and progression is imperative. Over the last few years, the histopathological alterations ultimately leading to progressed CCA have been better defined. In addition, the landscape of genetic and epigenetic alterations associated with cholangiocarcinogenesis has been unraveled due to the improvement in the transcriptomic and sequencing methodologies. However, this advancement in the knowledge of CCA has not been successfully translated into curative therapies for CCA to date, although encouraging results are coming from preclinical and clinical studies.
Considering the importance of CCA in the field of medicine and research, the journal Journal of Clinical Medicine is launching this Special Issue.
We deeply encourage you and your co-workers to submit your articles reporting on this important topic. Reviews or original articles dealing with the biochemical and molecular aspects associated with CCA diagnosis, molecular pathogenesis, and targeted therapies in the preclinical (experimental) and clinical setting are welcome.
Prof. Dr. Diego F. Calvisi
Guest Editor
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Keywords
- cholangiocarcinoma
- precision medicine
- molecular mechanisms
- signal transduction
- histopathology
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