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Clinical Management in Gastroesophageal Reflux
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Clinical Management in Gastroesophageal Reflux

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 1227

Special Issue Editor

Dr. Katarina B. Greer

E-Mail Website
Guest Editor
1. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA
2. Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA
Interests: gastroenterology disease; gastroparesis; idiopathic constipation; colorectal cancer gastroesophageal reflux; Barrett’s esophagus; cancer screening

Special Issue Information

Dear Colleagues,

The burden of gastroesophageal reflux disease has increased in the past decades with increasing prevalence of obesity worldwide. The invasive management of gastroesophageal reflux has evolved over the years shifting from open to laparoscopic surgeries and minimally invasive endoscopic procedures. The durability of invasive procedures is still debated. Th side effects of the long-term use of medical therapies are closely followed to assure safety of the patients who require lifelong treatment of reflux. Benefits of screening for esophageal adenocarcinoma utilizing non-endoscopic approaches are yet to be examined in large prospective trials. Despite international guidelines and worldwide consensus updates, evidence gaps are seen across the spectrum of reflux management. The aim of this Special Issue is to provide a comprehensive overview of the advances in diagnosis and treatment of gastroesophageal reflux, with particular interest in the use of innovative techniques and technologies. Therefore, researchers in the field of foregut disease management are encouraged to submit their findings as original articles or reviews to this Special Issue.

Dr. Katarina B. Greer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • GERD
  • diagnosis of refractory GERD
  • minimally invasive surgery
  • Barrett’s esophagus
  • esophageal adenocarcinoma screening

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Published Papers (1 paper)

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Research

11 pages, 1922 KiB  
Article
Association between Oral Microbiome and Gastroesophageal Reflux Severity
by Declan J. Power, Vincent Ho and Jerry Zhou
J. Clin. Med. 2024, 13(15), 4479; https://doi.org/10.3390/jcm13154479 - 31 Jul 2024
Viewed by 1054
Abstract
Background/Objectives: Gastroesophageal reflux disease (GORD) is caused by gastric contents refluxing back into the oesophagus and oral cavity. It can lead to injuries to the mucosa in the form of erosion and ulcers. Our past research have shown acid reflux severity and disease [...] Read more.
Background/Objectives: Gastroesophageal reflux disease (GORD) is caused by gastric contents refluxing back into the oesophagus and oral cavity. It can lead to injuries to the mucosa in the form of erosion and ulcers. Our past research have shown acid reflux severity and disease progression is associated with alternations in the microbiota of the distal oesophagus. The aim of this study was to explore whether changes in the oral microbiota occurred in GORD patients and establish any associations with reflux severity. Methods: Fresh mouthwash samples were collected from 58 patients experiencing reflux symptoms referred for 24 h pH monitoring. The participants were categorised into three groups based on their DeMeester scores: Normal (<14.72), Mild (14.2–50), and Moderate/severe (>51). Microorganism identity and diversity were generated using hypervariable tag sequencing and analysing the V1–V3 region of the 16S rRNA gene. Results: No differences in microbiota diversity were found in oral microbiota between groups using the Chiao1 diversity index and Shannon diversity index. Microbiota in the Mild group showed reductions in Rothia dentocariosa and Lautropia, while Moryella and Clostridiales_1 were increased compared with the Normal group. In the Moderate/severe group, the abundance of Rothia aeria was reduced compared with the Normal group, while Schwartzia, Rs_045, Paludibacter, S. satelles, Treponema, and T. socranskii all had increased abundance. The abundance of Prevotella pallens was higher in the Mild group compared with Moderate/severe, while S. satelles and Paludibacter abundances were lower. Conclusions: Our study shows the oral microbiome show significant differences between acid reflux severity groups, as categorised by DeMeester score. Full article
(This article belongs to the Special Issue Clinical Management in Gastroesophageal Reflux)
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