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Outcome of Complex Congenital Heart Defects
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Outcome of Complex Congenital Heart Defects

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 389

Special Issue Editors

Dr. Cristina Ciuca

E-Mail Website
Guest Editor
Pediatric Cardiology and Adult Congenital Heart Disease Program, Department of Cardio-Thoracic and Vascular Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
Interests: congenital heart disease; cardiac imaging; exercise capacity; pregnancy
Special Issues, Collections and Topics in MDPI journals
Dr. Emanuela Angeli

E-Mail Website
Guest Editor
Pediatric Cardiology and Adult Congenital Heart Disease Program, Department of Cardio-Thoracic and Vascular Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
Interests: congenital heart disease; cardiac surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Congenital heart diseases (CHD) are the most common congenital defects in live-born children, with an estimated incidence of almost one per 100 babies. The spectrum of CHD ranges from an isolated defect in the atrial septum without the need for any intervention to complex structural cardiovascular abnormalities requiring  multiple  interventions early in life.

Due to the advances in the care for patients with CHD, survival has significantly improved over the last few decades. Therefore, a multidisciplinary long-term follow-up should be planned to involve an ACHD (adults with congenital heart disease) team. Cardiac surgeons, cardiologists and CHD sub-specialists continuously encounter challenges as these adult patients develop new comorbidities. Patients often require long-term follow-up with lifelong cardiac problems and sometimes need re-operation on surgical repairs carried out previously. 

The aim of this Special Issue is to gather research on the outcome of congenital heart disease, focusing on diagnosis, therapy, and outcome of complex CHD lesions. The submissions presented in this Special Issue will include review articles, research manuscripts, short contributions, and case reports. This may be also an opportunity for cardiac surgeons, cardiologists, obstetricians, sonographers, fellows, and trainees to contribute and showcase their area of expertise. 

You may choose our Joint Special Issue in Journal of Cardiovascular Development and Disease.

Dr. Cristina Ciuca
Dr. Emanuela Angeli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • congenital heart disease
  • fontan circulation
  • tetralogy of Fallot
  • transposition of the great arteries
  • ebstein disease
  • coarctation of the aorta
  • systemic right ventricle in biventricular circulation
  • heart transplantation in congenital heart disease
  • septal defects
  • adults with congenital heart disease
  • exercise capacity

Published Papers (1 paper)

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24 pages, 3540 KiB  
Systematic Review
Comparison of Morbidity and Mortality Outcomes between Hybrid Palliation and Norwood Palliation Procedures for Hypoplastic Left Heart Syndrome: Meta-Analysis and Systematic Review
by Christopher Iskander, Ugonna Nwankwo, Krithika K. Kumanan, Saurabh Chiwane, Vernat Exil, Lia Lowrie, Corinne Tan, Charles Huddleston and Hemant S. Agarwal
J. Clin. Med. 2024, 13(14), 4244; https://doi.org/10.3390/jcm13144244 (registering DOI) - 20 Jul 2024
Viewed by 81
Abstract
Background/Objectives: Hybrid palliation (HP) procedures for hypoplastic left heart syndrome (HLHS) are increasing. Our objective was to compare mortality and morbidity following HP and NP (Norwood palliation) procedures. Methods: Systematic review and meta-analysis of HLHS patients of peer-reviewed literature between 2000 [...] Read more.
Background/Objectives: Hybrid palliation (HP) procedures for hypoplastic left heart syndrome (HLHS) are increasing. Our objective was to compare mortality and morbidity following HP and NP (Norwood palliation) procedures. Methods: Systematic review and meta-analysis of HLHS patients of peer-reviewed literature between 2000 and 2023. Mortality and/or heart transplantation in HP versus NP in the neonatal period, interstage period, and at 1, 3 and 5 years of age, and morbidity including completion of Stage II and Stage III palliation, unexpected interventions, pulmonary artery pressures, right ventricle function, neurodevelopmental outcomes and length of hospital stay were evaluated. Results: Twenty-one (meta-analysis: 16; qualitative synthesis: 5) studies evaluating 1182 HLHS patients included. HP patients had higher interstage mortality (RR = 1.61; 95% CI: 1.10–2.33; p = 0.01) and 1-year mortality (RR = 1.22; 95% CI: 1.03–1.43; p = 0.02) compared to NP patients without differences in 3- and 5-years mortality. HP procedure in high-risk HLHS patients had lower mortality (RR = 0.48; 95% CI: 0.27–0.87; p = 0.01) only in the neonatal period. HP patients underwent fewer Stage II (RR = 0.90; 95% CI: 0.81–1.00; p = 0.05) and Stage III palliation (RR = 0.78; 95% CI: 0.69–0.90; p < 0.01), had more unplanned interventions (RR = 3.38; 95% CI: 2.04–5.59; p < 0.01), and longer hospital stay after Stage I palliation (weighted mean difference = 12.88; 95% CI: 1.15–24.62; p = 0.03) compared to NP patients. Conclusions: Our study reveals that HP, compared to NP for HLHS, is associated with increased morbidity risk without an improved survival rate. Full article
(This article belongs to the Special Issue Outcome of Complex Congenital Heart Defects)
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