New Insights into Irritable Bowel Syndrome

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 26 October 2024 | Viewed by 805

Special Issue Editors


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Guest Editor
Division of Gastroenterology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy
Interests: disorders of gut-brain interaction; irritable bowel syndrome; eosinophilic gastrointestinal disorders; diarrhoea; abdominal pain; high-resolution manometry

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Guest Editor
Gastrointestinal Unit, Department of Translational Sciences and New Technology in Medicine and Surgery, University of Pisa, 56124 Pisa, Italy
Interests: disorders of gut-brain interaction; irritable bowel syndrome; FODMAPs; low-FODMAPs diet; anorectal manometry; chronic constipation; functional dyspepsia; gastroparesis
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Special Issue Information

Dear colleagues,

Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disease that represents a significant cause of morbidity worldwide. The disease significantly affects patients’ quality of life, work productivity and social functioning. The pathophysiology of IBS is not completely understood and its diagnosis should be made based on the Rome IV criteria. Nevertheless, the severity of the patient’s symptoms and concerns sometimes drives the physician to perform useless and/or expensive diagnostic tests, transforming IBS into a diagnosis of exclusion. Therefore, a deeper knowledge of IBS mechanisms is mandatory to improve the management of the disease. Conventional treatments include lifestyle changes, diets, probiotics, laxatives, antidiarrhoeals and antispasmodics. More recently, other therapies have been investigated in randomized controlled trials and observational studies, including faecal microbiota transplantation, central neuromodulators, intestinal secretagogues, drugs acting on opioid or 5-HT receptors, minimally absorbed antibiotics, and psychological therapies.

The scientific community will certainly benefit from updated reviews focusing on the optimal management of IBS. In this Special Issue, we invite you to submit your updated review addressing the management aspects and/or therapeutics of IBS.

We look forward to your contribution relating to this cutting-edge Special Issue of the Journal of Clinical Medicine.

Dr. Pierfrancesco Visaggi
Prof. Dr. Massimo Bellini
Guest Editors

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Keywords

  • irritable bowel syndrome
  • management
  • disorders of gut–brain interactions
  • neuromodulators
  • fecal microbiota
  • probiotics
  • diet
  • FODMAPs
  • intestinal secretagogues
  • 5-HT receptors

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Published Papers (1 paper)

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Review

17 pages, 1038 KiB  
Review
The Latest Data Concerning the Etiology and Pathogenesis of Irritable Bowel Syndrome
by Vlad Alexandru Ionescu, Gina Gheorghe, Teodor Florin Georgescu, Nicolae Bacalbasa, Florentina Gheorghe and Camelia Cristina Diaconu
J. Clin. Med. 2024, 13(17), 5124; https://doi.org/10.3390/jcm13175124 - 29 Aug 2024
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Abstract
Globally, irritable bowel syndrome (IBS) is present in approximately 10% of the population. While this condition does not pose a risk of complications, it has a substantial impact on the patient’s quality of life. Moreover, this disease has a significant financial impact on [...] Read more.
Globally, irritable bowel syndrome (IBS) is present in approximately 10% of the population. While this condition does not pose a risk of complications, it has a substantial impact on the patient’s quality of life. Moreover, this disease has a significant financial impact on healthcare systems. This includes the direct costs associated with the diagnosis and treatment of these patients, as well as the indirect costs that arise from work absenteeism and reduced productivity. In light of these data, recent research has focused on elucidating the pathophysiological basis of this condition in order to improve the quality of life for affected individuals. Despite extensive research to date, we still do not fully understand the precise mechanisms underlying IBS. Numerous studies have demonstrated the involvement of the gut–brain axis, visceral hypersensitivity, gastrointestinal dysmotility, gut microbiota dysbiosis, food allergies and intolerances, low-grade mucosal inflammation, genetic factors, and psychosocial factors. The acquisition of new data is crucial for the advancement of optimal therapeutic approaches aimed at enhancing the general health of these patients while simultaneously reducing the financial burden associated with this ailment. Full article
(This article belongs to the Special Issue New Insights into Irritable Bowel Syndrome)
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