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Innovations in Retinal Imaging
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Innovations in Retinal Imaging

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (27 April 2023) | Viewed by 4418

Special Issue Editors

Dr. Rachid Tahiri

E-Mail Website
Guest Editor
Ambulatory Surgery Department, Avranches Granville Hospital, Granville, France
Interests: medical retina; surgical retina; cataract surgery; optical coherence tomography (OCT); ophthalmic imaging; retinal imaging
Dr. Florence Coscas

E-Mail Website
Guest Editor
1. Odeon Ophthalmology Center, Paris, France
2. President of the Retina French Society, Paris, France
Interests: medical retina; age-related macular degeneration; OCT; OCT angiography; fluorescein angiography
Dr. Michel Puech

E-Mail Website
Guest Editor
1. Explore Vision, Paris, France
2. President of VuExplorer Institute, Rueil Malmaison, France
3. President of the 2022 World Ophthalmic Ultrasound Congress (SIDUO XXVIII), Paris, France
Interests: ophthalmic imaging; medical retina; age-related macular degeneration; glaucoma; OCT; ocular ultrasound imaging

Special Issue Information

Dear Colleagues,

Retinal imaging has changed dramatically during the last three decades, with increasingly more accurate and innovative technologies. Consequently, it plays an essential role in the documentation, diagnosis, follow-up, and understanding of the pathophysiologic of numerous retinal diseases. Since the development of the first prototype of optical coherence tomography (OCT) in 1993, many innovations have been developed, such as spectral-domain OCT (SD-OCT), swept-source OCT (SS-OCT), en face OCT, OCT angiography, and intraoperative OCT. These innovations have unquestionably improved the resolution and, thus, revolutionized the accuracy of the diagnosis and the management of retinal diseases.

Retinal imaging is a booming field; the development of new technologies, such as multimodal imaging and ultrawide field retinal imaging, makes it possible to describe increasingly reliable, accurate, and precise semiologies. In addition, among new innovative retinal imaging technologies, laser Doppler holography has been shown to be a promising tool that opens exciting perspectives for a better understanding of retinal vascular conditions.

Despite this revolution in ophthalmic imaging, numerous challenges are emerging, such as the place of artificial intelligence (AI). Indeed, the development of this technology is creating unprecedented eye-care paradigms, as the United States Food and Drug Administration approved autonomous AI to detect diabetic retinopathy. Thus, it has enabled disease diagnosis without a clinician's participation. With the galloping development of digital imaging technology, telemedicine, and digital health, the advent of AI could profoundly change how we deliver care to our patients in the next few years.

This Special Issue aims to attract original research and review articles on retinal imaging innovations. We are particularly interested in articles reporting novel concepts, new technologies, or new semiologies. We believe this Special Issue will improve our knowledge and understanding and spot a frontier of information regarding the progress, hopes, and challenges of emerging imaging technologies in ophthalmology.

Dr. Rachid Tahiri
Dr. Florence Coscas
Dr. Michel Puech
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retinal imaging
  • optical coherence tomography (OCT)
  • spectral-domain OCT
  • swept-source OCT
  • en face OCT
  • OCT-angiography
  • directional OCT (D-OCT)
  • intraoperative OCT
  • retinal diseases new semiology
  • ocular echography
  • fluorescein angiography
  • indocyanine green angiography
  • laser doppler holography
  • adaptative optics ophthalmoscope
  • scanning laser ophthalmoscope
  • ultra-wide-field imaging
  • multimodal imaging
  • age-related macular degenerescence
  • retinal central vein occlusion
  • diabetic retinopathy
  • macular diabetic edema
  • retinal dystrophies
  • retinopathy of prematurity
  • retinoblastoma
  • artificial intelligence in retinal imaging

Published Papers (3 papers)

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Research

10 pages, 11096 KiB  
Article
Predictive Factors of Visual Outcome in Treatment-Naïve Diabetic Macular Edema: Preliminary Results from the Clinical Study “FOVEA”
by Rita Serra, Florence Coscas, Jean François Boulet, Diogo Cabral, Thi Ha Chau Tran, Giuliana Solinas, Antonio Pinna, Marco Lupidi, Gabriel Coscas and Fovea Study Group
J. Clin. Med. 2023, 12(12), 3870; https://doi.org/10.3390/jcm12123870 - 6 Jun 2023
Cited by 2 | Viewed by 1062
Abstract
Diabetic macular edema (DME) is a common cause of vision impairment in diabetic retinopathy. The aim of this study was to analyze the relationship between visual outcome and anatomic changes detected by traditional multimodal retinal imaging and optical coherence tomography angiography (OCTA) in [...] Read more.
Diabetic macular edema (DME) is a common cause of vision impairment in diabetic retinopathy. The aim of this study was to analyze the relationship between visual outcome and anatomic changes detected by traditional multimodal retinal imaging and optical coherence tomography angiography (OCTA) in DME eyes under treatment with Aflibercept. Methods: Sixty-six DME eyes of 62 patients under treatment with intravitreal Aflibercept and with one-year follow-up were enrolled. All participants underwent a full ophthalmic evaluation, including best correct visual acuity (BCVA) measurement, spectral-domain optical coherence tomography, fluorescein angiography and OCTA, both at baseline and final examination. Fractal OCTA analysis of the superficial and deep capillary plexus (SCP and DCP) was performed to estimate vascular perfusion density and lacunarity (LAC). Results: At the final examination, there was a significant improvement in terms of BCVA and central macular thickness (CMT). Furthermore, eyes with CMT <373 µm at baseline reached the higher BCVA at the last follow-up. Eyes with CMT ≥373 µm and DCP LAC <0.41 reached a higher final BCVA, if compared with eyes showing the same CMT but higher initial LAC. Conclusion: A 12-month treatment with intravitreal Aflibercept for DME resulted in significant visual and anatomic improvement. Multimodal retinal imaging, together with fractal OCTA analysis, may provide useful biomarkers, predictive of visual outcome in DME. Full article
(This article belongs to the Special Issue Innovations in Retinal Imaging)
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9 pages, 807 KiB  
Article
Relevance of Visual Acuity Measurement for Therapeutic Decisions in Age-Related Macular Degeneration
by Thibaud Mathis, Batoul El Ameen, Mayeul Chaperon, Yasmine Serrar, François Devin, Mikhail Dziadzko, Amina Rezkallah and Laurent Kodjikian
J. Clin. Med. 2023, 12(2), 522; https://doi.org/10.3390/jcm12020522 - 9 Jan 2023
Cited by 1 | Viewed by 1297
Abstract
The aim of this study is to assess if the decision to retreat could be determined by anatomical criteria (mostly driven by optical coherence tomography (OCT)-guided strategy) rather than the gold standard (visual acuity (VA) and OCT) in patients with neovascular age-related macular [...] Read more.
The aim of this study is to assess if the decision to retreat could be determined by anatomical criteria (mostly driven by optical coherence tomography (OCT)-guided strategy) rather than the gold standard (visual acuity (VA) and OCT) in patients with neovascular age-related macular degeneration (nAMD). A cross-sectional study of 142 eyes already treated for nAMD from September 2021 to December 2021 was performed. At inclusion, a first therapeutic decision was made based on the analysis of the OCT. This decision was then maintained or modified after being made aware of the patient’s VA. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated. The OCT-guided strategy matched the gold standard for treatment decisions in 131 of the 142 eyes included (92.3%). The sensitivity and specificity of the OCT-guided strategy for the retreatment decision were 94.0% and 89.8%, respectively. PPV and NPV were 92.9% and 91.4%, respectively. Considering the treatment regimen, eyes followed under the Pro ReNata regimen showed better sensitivity (100%) and specificity (93.3%) than eyes followed under the treat and extend regimen (93.5% and 88.6%, respectively). Based on the findings of this study, the follow-up for selected patients with nAMD under anti-VEGF treatment could be monitored without regular VA testing with acceptable performance. Full article
(This article belongs to the Special Issue Innovations in Retinal Imaging)
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10 pages, 1570 KiB  
Article
Evaluation of the Correlation between Regional Retinal Ganglion Cell Damage and Visual Field Sensitivity in Patients with Advanced Glaucoma
by Amina Rezkallah, Ikrame Douma, Maxime Bonjour, Thibaud Mathis, Laurent Kodjikian and Philippe Denis
J. Clin. Med. 2022, 11(16), 4880; https://doi.org/10.3390/jcm11164880 - 19 Aug 2022
Cited by 2 | Viewed by 1302
Abstract
(1) Background: to investigate the correlation between structural (retinal ganglion cells and retinal nerve fibers) and functional alterations analyzed point-by-point in the central 10 degrees of the visual field of patients with advanced glaucoma using Humphrey 10-2 visual field tests. (2) Methods: Single-center [...] Read more.
(1) Background: to investigate the correlation between structural (retinal ganglion cells and retinal nerve fibers) and functional alterations analyzed point-by-point in the central 10 degrees of the visual field of patients with advanced glaucoma using Humphrey 10-2 visual field tests. (2) Methods: Single-center prospective cohort study carried on from October 2018 to February 2019 at the Croix-Rousse hospital, Lyon, France. The primary outcome measure was the point-by-point correlation between retinal sensitivity (Humphrey 10-2) and retinal ganglion cell complex (GCC) thickness. (3) Results: 29 eyes of 27 patients were examined. Of these, 15 eyes had a mean deviation (MD) less than −20 dB. There were statistically significant linear relationships between GCC thickness and 10-2 visual field sensitivity for several points in the lower part of the visual field, with lower retinal sensitivity being associated with thicker GCC layers. There were no strong linear relationships or statistically significant correlations in the other regions of the visual field. For the patients with MD < −20 dB, there were statistically significant linear relationships between GCC thickness and 10-2 visual field sensitivity for several points in the superior nasal region. Retinal sensitivity was not correlated with retinal nerve fibre layer thickness. (4) Conclusions: In this study of patients with advanced glaucoma, GCC thickness was linearly associated with 10-2 visual field sensitivity in certain regions, negatively for patients with less-severe glaucoma. The initial thickening raises questions about the apoptosis mechanism, while the thinning observed in the most severe cases is consistent with the ganglion cell death identified on visual field tests. Full article
(This article belongs to the Special Issue Innovations in Retinal Imaging)
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