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New Advances in Hepato-Pancreato-Biliary (HPB) Surgery
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New Advances in Hepato-Pancreato-Biliary (HPB) Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 4200

Special Issue Editors

Dr. Dimitrios Symeonidis

E-Mail Website
Guest Editor
Assistant Professor, Department of Surgery, University Hospital of Larissa, Larissa, Greece
Interests: HPB surgery
Prof. Dr. Dimitris Zacharoulis

E-Mail Website
Guest Editor
Department of Surgery, University Hospital of Larissa, Larissa, Greece
Interests: HPB surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Konstantinos Tepetes

E-Mail Website
Guest Editor
Department of Surgery, University Hospital of Larissa, Larissa, Greece
Interests: HPB surgery

Special Issue Information

Dear Colleagues,

The treatment of malignant tumors located in the pancreas, the liver or the extrahepatic biliary tree requires an MDT approach. Surgery represents the only treatment option with curative intent. Recently, significant progress has been documented in regard to the operative and the oncological outcomes following various HPB procedures. However, we still have a long way to go and focused research on the field becomes of paramount importance.

We are pleased to invite you to contribute your valuable work to the Special Issue “New Advances in HPB surgery”. This Special Issue aims to highlight the most recent innovations in the management of patients with pancreatic, liver and biliary malignancies focusing especially on perioperative management and the operative / interventional outcomes.

We look forward to receiving your contributions.

Dr. Dimitrios Symeonidis
Prof. Dr. Dimitris Zacharoulis
Prof. Dr. Konstantinos Tepetes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreatic cancer
  • colorectal cancer liver metastases
  • hepatocellular carcinoma
  • pancreaticoduodenectomy
  • distal pancreatectomy
  • liver resection
  • hepatectomy

Published Papers (2 papers)

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Research

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12 pages, 9862 KiB  
Article
Prognostic Value of Combined Neutrophil-to-Lymphocyte Ratio and Imaging Tumor Capsule in Solitary Hepatocellular Carcinoma Patients after Narrow-Margin Hepatectomy
by Desheng Chen, Pengjuan Mao, Chen Sun, Xuhui Fan, Qi Zhu, Zeping Chen, Zeping He, Yichao Lou and Hongcheng Sun
J. Clin. Med. 2024, 13(2), 351; https://doi.org/10.3390/jcm13020351 - 8 Jan 2024
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Abstract
Background: The study aimed to investigate the clinical value and prognostic patterns of the neutrophil-to-lymphocyte ratio (NLR) and imaging tumor capsule (ITC) in solitary hepatocellular carcinoma (HCC) patients undergoing narrow-margin hepatectomy. Methods: Data for solitary HCC patients treated with narrow-margin surgery were extracted [...] Read more.
Background: The study aimed to investigate the clinical value and prognostic patterns of the neutrophil-to-lymphocyte ratio (NLR) and imaging tumor capsule (ITC) in solitary hepatocellular carcinoma (HCC) patients undergoing narrow-margin hepatectomy. Methods: Data for solitary HCC patients treated with narrow-margin surgery were extracted from Shanghai General Hospital. Clinical features of recurrence-free survival (RFS), overall survival (OS), and early recurrence were investigated by Cox/logistic regression. The significant variables were subsequently incorporated into the nomogram pattern. Survival analysis stratified by NLR and ITC was also performed. Results: The study included a cohort of 222 patients, with median RFS and OS of 24.083 and 32.283 months, respectively. Both an NLR ≥ 2.80 and incomplete ITC had a significant impact on prognosis. NLR and ITC independently affected RFS and OS, whereas alpha-fetoprotein (AFP) and ITC were identified as independent factors for early relapse. The RFS and OS nomogram, generated based on the Cox model, demonstrated good performance in validation. The combination of NLR and ITC showed greater predictive accuracy for 5-year RFS and OS. Subgroups with an NLR ≥ 2.80 and incomplete ITC had the worst prognosis. Conclusions: Both NLR and ITC significantly affected RFS, OS, and early recurrence among solitary HCC patients who underwent narrow-margin hepatectomy. The combination of NLR and ITC has the potential to guide rational clinical treatment and determine the prognosis. Full article
(This article belongs to the Special Issue New Advances in Hepato-Pancreato-Biliary (HPB) Surgery)
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17 pages, 931 KiB  
Systematic Review
BILE: A Literature Review Based Novel Clinical Classification and Treatment Algorithm of Iatrogenic Bile Duct Injuries
by Dimitrios Symeonidis, Konstantinos Tepetes, George Tzovaras, Athina A. Samara and Dimitrios Zacharoulis
J. Clin. Med. 2023, 12(11), 3786; https://doi.org/10.3390/jcm12113786 - 31 May 2023
Viewed by 2982
Abstract
Purposes: The management of patients with iatrogenic bile duct injuries (IBDI) is a challenging field, often with dismal medico legal projections. Attempts to classify IBDI have been made repeatedly and the final results were either analytical and extensive but not useful in everyday [...] Read more.
Purposes: The management of patients with iatrogenic bile duct injuries (IBDI) is a challenging field, often with dismal medico legal projections. Attempts to classify IBDI have been made repeatedly and the final results were either analytical and extensive but not useful in everyday clinical practice systems, or simple and user friendly but with limited clinical correspondence approaches. The purpose of the present review is to propose a novel, clinical classification system of IBDI by reviewing the relevant literature. Methods: A systematic literature review was conducted by performing bibliographic searches in the available electronic databases, including PubMed, Scopus, and the Cochrane Library. Results: Based on the literature results, we propose a five (5) stage (A, B, C, D and E) classification system for IBDI (BILE Classification). Each stage is correlated with the recommended and most appropriate treatment. Although the proposed classification scheme is clinically oriented, the anatomical correspondence of each IBDI stage has been incorporated as well, using the Strasberg classification. Conclusions: BILE classification represents a novel, simple, and dynamic in nature classification system of IBDI. The proposed classification focuses on the clinical consequences of IBDI and provides an action map that can appropriately guide the treatment plan. Full article
(This article belongs to the Special Issue New Advances in Hepato-Pancreato-Biliary (HPB) Surgery)
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