Hepatobiliary and Pancreatic Surgery: Diagnosis, Management and Future Opportunities
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 170
Special Issue Editor
Special Issue Information
Dear Colleagues,
The global adoption of minimally invasive techniques, such as laparoscopic and robot-assisted surgery, has been rapid in hepatobiliary and pancreatic surgery. However, there is still a lack of comprehensive studies comparing these methods to open surgery, particularly in terms of short- and long-term outcomes. While the benefits of laparoscopic surgery have been established through numerous studies, the efficacy of robot-assisted surgery remains uncertain. The rapid advancements in minimally invasive techniques have significantly impacted clinical practice, reducing hospital stays and complications. This Special Issue seeks to examine the future prospects of surgical procedures in hepatobiliary and pancreatic surgery in greater depth.
Dr. Tomoyuki Abe
Guest Editor
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Keywords
- laparoscopic hepatectomy
- HCC
- ICC
- acute cholecystitis
- bailout surgery
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Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Preoperative elevated Neutrophil-to-Lymphocite Ratio should be an indication for neoadjuvant chemotherapy in patients with periampullary and pancreatic cancers and normal levels of preoperative CA 19.9.
Authors: Pau Plá Sánchez; Joaquín Marchena Gómez; Natalia Afonso Luis; Francisco José Cruz Benavides
Affiliation: Universidad de Las Palmas de Gran Canaria
Abstract: Background. One of the most important prognostic factors in periampullary and pancreatic cancers is perineural infiltration, whose preoperative detection could be decisive in selecting which patients should not undergo upfront surgery. We evaluated CA 19.9 and the Neutrophil-to-lymphocyte ratio (NLR) as preoperative predictors of perineural invasion (PNI).
Methods: Retrospective analysis including patients with periampullary and pancreatic cancers who underwent curative resection from January 2013 to August 2023 in our institution. A univariate analysis and multivariate analysis were performed to analyze the association between the CA 19.9 and NLR with the existence of PNI.
Results: A total of 136 patients were included in the study. PNI was observed in 95 (69.9%) patients. The selected cut-off points were NLR: 2.2, and CA 19.9: 37 U/mL. In univariate analysis, NLR (p=0.001) and CA 19.9 (p=0.006) were statistically significantly associated with PNI. In multivariate analysis, baseline NLR levels (p=0.012; OR: 1.95; 95%CI: 1.16-3.29) as well as CA 19.9 levels (p=0.026; OR: 1.67; 95%CI: 1.06-2.64) remained independent prognostic factors for PNI. The area under de ROC curves was 0.67 for CA 19.9 (p=0.004) and 0.72 for NLR (p
