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Hepatobiliary and Pancreatic Surgery: Diagnosis, Management and Future Opportunities
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Hepatobiliary and Pancreatic Surgery: Diagnosis, Management and Future Opportunities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 313

Special Issue Editor

Dr. Tomoyuki Abe

E-Mail Website
Guest Editor
Department of Gastroenterological Surgery, National Hospital Organization Higashihiroshima Medical Center, Higashihiroshima 7390041, Japan
Interests: laparoscopic hepatectomy; HCC; ICC; acute cholecystitis; bailout surgery

Special Issue Information

Dear Colleagues,

The global adoption of minimally invasive techniques, such as laparoscopic and robot-assisted surgery, has been rapid in hepatobiliary and pancreatic surgery. However, there is still a lack of comprehensive studies comparing these methods to open surgery, particularly in terms of short- and long-term outcomes. While the benefits of laparoscopic surgery have been established through numerous studies, the efficacy of robot-assisted surgery remains uncertain. The rapid advancements in minimally invasive techniques have significantly impacted clinical practice, reducing hospital stays and complications. This Special Issue seeks to examine the future prospects of surgical procedures in hepatobiliary and pancreatic surgery in greater depth.

Dr. Tomoyuki Abe
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • laparoscopic hepatectomy
  • HCC
  • ICC
  • acute cholecystitis
  • bailout surgery

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Published Papers (1 paper)

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Research

14 pages, 628 KiB  
Article
Discrepancy Between Conventional Coagulation Tests and Thromboelastography During the Early Postoperative Phase of Liver Resection in Neoplastic Patients: A Prospective Study Using the New-Generation TEG®6s
by Rita Gaspari, Paola Aceto, Simone Carelli, Alfonso Wolfango Avolio, Maria Grazia Bocci, Stefania Postorino, Giorgia Spinazzola, Mariagiovanna Caporale, Felice Giuliante and Massimo Antonelli
J. Clin. Med. 2025, 14(9), 2866; https://doi.org/10.3390/jcm14092866 - 22 Apr 2025
Abstract
Background: Thromboelastography-6s (TEG®6s), a novel device developed to assess coagulation status, presents advantages such as less frequent calibration, ease of use, and greater stability against movements compared to the previous system (TEG5000). This is the first study in the literature [...] Read more.
Background: Thromboelastography-6s (TEG®6s), a novel device developed to assess coagulation status, presents advantages such as less frequent calibration, ease of use, and greater stability against movements compared to the previous system (TEG5000). This is the first study in the literature to compare coagulation profiles in the early postoperative period of liver resection (LR) using conventional coagulation tests (CCTs) and TEG®6s. Methods: Forty-six adult patients admitted to the ICU post-surgery after elective LR for malignancy were included. CCTs were used to classify patients into hypocoagulable (HCG) (platelet count < 80 × 109/L, international normalized ratio ≥ 1.4, or activated partial thromboplastin time > 38 s) and normocoagulable (all other cases) groups. Mann–Whitney tests, Spearman’s correlation, and linear regression were used. Results: On ICU admission, nineteen (41.3%) patients had a hypocoagulable profile based on CCTs, but only two (10.5%) of them were rated as hypocoagulable by TEG (p = 0.165). Intraoperatively, HCG patients experienced higher estimated blood loss (EBL) (p = 0.002); they required more fluids (p = 0.019), and more of them received red blood cell transfusions (p = 0.025). They also had higher postoperative arterial lactate levels (p = 0.036). Postoperative 12 h EBL was similar in the two groups (around 150 mL). The ICU stay was longer for HCG group (p = 0.010). Weak associations were observed between TEG/CCTs measures of coagulation initiation [e.g., between R time citrated rapid TEG, and international normalized ratio (r2 = 0.448; p < 0.001)], clot formation [i.e., between conventional fibrinogen value using Clauss method and α-angle citrated rapid TEG (r2 = 0.542; p < 0.001)], and clot strength [e.g., between conventional fibrinogen and citrated kaolin maximum amplitude (r2 = 0.484; p < 0.001)]. Conclusions: CCTs revealed hypocoagulability that was not confirmed by TEG®6s. However, the thromboelastography coagulation profile was more consistent with the detected non-relevant postoperative bleeding. Full article
(This article belongs to the Special Issue Hepatobiliary and Pancreatic Surgery: Diagnosis, Management and Future Opportunities)
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