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New Clinical Advances in Macular Degeneration
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New Clinical Advances in Macular Degeneration

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 18 November 2024 | Viewed by 1223

Special Issue Editors

Dr. Alaa Din Abdin

E-Mail Website
Guest Editor
Department of Ophthalmology, Saarland University Medical Center (UKS), 66421 Homburg, Germany
Interests: macular degeneration
Prof. Dr. Berthold Seitz

E-Mail Website
Guest Editor
Department of Ophthalmology, Saarland University Medical Center, Kirrberger Str. 100, 66421 Homburg, Germany
Interests: cornea

Special Issue Information

Dear Colleagues,

Age-related macular degeneration (AMD) is a progressive macular disease that represents an increasing burden for both patients and healthcare systems worldwide. The clinical manifestations of AMD range from drusen to geographic atrophy and macular neovascularization.

Many attempts have been undertaken to improve disease classification and characterize biomarkers based on spectral-domain optical coherence tomography (SD OCT) and, more recently, OCT angiography. These validated biomarkers can be combined with clinical findings to create promising therapies.

Until a few years ago, there was no proven treatment for dry AMD. However, early and intermediate AMD have recently been recognized as multifactorial entities that respond to various therapies, including complement factors and statins. In addition, several studies have supported the use of anti-complement therapies to reduce the progression of geographic atrophy. On the other hand, many new agents against the vascular endothelial growth factor have recently been approved for the treatment of neovascular AMD. Nevertheless, we still have limited knowledge of the indication criteria and outcomes of these new treatment agents following different treatment protocols.

This Special Issue of the Journal of Clinical Medicine focuses on clinical advances in macular degeneration in terms of diagnostic methods, biomarkers, new therapeutic concepts, agents, and protocols.

Dr. Alaa Din Abdin
Prof. Dr. Berthold Seitz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • age-related macular degeneration
  • anti-vascular endothelial growth factor
  • complement factor
  • geographic atrophy
  • macular neovascularization
  • OCT and OCT angiography
  • biomarkers

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Published Papers (1 paper)

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15 pages, 5569 KiB  
Article
Natural History of Visual Acuity and Microperimetry-Based Functional Outcome Measures of the Macula in Patients with Geographic Atrophy: A Retrospective Chart Review Study in Germany
by Paul Kohlhas, Alaa Din Abdin, Wissam Aljundi, Ann-Isabel Mattern, Machteld Devenijn, Kathrin Borchert, Andreas Fricke, Tammo Viering, Jürgen Wasem, Berthold Seitz and Hakan Kaymak
J. Clin. Med. 2024, 13(13), 3959; https://doi.org/10.3390/jcm13133959 - 6 Jul 2024
Viewed by 949
Abstract
Background/Objectives: Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) leading to the progressive and irreversible loss of visual function. Characteristics of GA include atrophic lesions resulting from the loss of photoreceptors, retinal pigment epithelium, and choriocapillaris. During GA progression, [...] Read more.
Background/Objectives: Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD) leading to the progressive and irreversible loss of visual function. Characteristics of GA include atrophic lesions resulting from the loss of photoreceptors, retinal pigment epithelium, and choriocapillaris. During GA progression, atrophic lesions typically advance from the macular periphery to the center, affecting foveal light sensitivity and visual acuity. This study analyzed changes in light sensitivity and visual acuity during the natural course of GA progression using the topographic analysis of structural and functional changes based on Early Treatment Diabetic Retinopathy Study (ETDRS) charts, multimodal imaging, and microperimetry assessment. Methods: Medical chart data of GA patients between 2014 and 2022 from the Internationale Innovative Ophthalmochirurgie GbR (I.I.O.) research center (Düsseldorf, Germany) were retrospectively analyzed. All patient eyes fulfilling the phase 3 OAKS study inclusion criteria were included and followed up for 60 months. The imputation of missing measurements and dropouts was performed by linear mixed models. Results: A total of 20 GA eyes from 13 GA patients were included in the study. At the index, 53.8% of patients had bilateral GA, with 70.0% of the eyes showing multifocal GA and 30.0% subfoveal encroachment (SFE). A total of 35.0% of the eyes had 2–5, and 15.0% over 20, areas of atrophy. Over time, the GA lesion size increased from 6.4 mm2 to 11.8 mm2 (1.08 mm2/year). After an average observation time of 2.9 years, 78.6% of the initially unaffected study eyes developed SFE. The percentage of study eyes without visual impairment decreased from 55.0% to 30.0%, with mean normal-luminance best-corrected visual acuity (NL-BCVA) reducing from 63.7 to 55.7 ETDRS letters. The share of absolute scotoma points in microperimetry assessment increased from 15.7% to 43.5% while overall average macular sensitivity declined from 15.7 dB to 7.4 dB. Conclusions: The substantial deterioration of macular outcomes and visual function was comprehensively detected. The results were a documentation of structural and functional aspects of the natural progression of GA for a 60-month follow-up, providing a typical outline for AMD patients with GA. Full article
(This article belongs to the Special Issue New Clinical Advances in Macular Degeneration)
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