Personalized Therapy and Clinical Outcome for Lung Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 2922

Special Issue Editor


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Guest Editor
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
Interests: lung surgery; idiopathic pulmonary fibrosis; biomarker

Special Issue Information

Dear Colleagues,

Personalized drug treatment based on biomarker-derived evidence of molecular pathway and oncogene addiction is essential for lung cancer therapy. Recently, the development of immune-checkpoint inhibitors has dramatically altered the strategy of lung cancer treatment. Although these drugs have significantly improved the clinical outcome of lung cancer, conventional therapies such as surgery, radiation, and chemotherapy still have crucial roles. Given the development of systemic therapy, local therapy is no longer limited to early-stage cancer and can be applied to advanced cancer with oligometastasis. Systemic and/or local therapy should be ‘personalized’ considering patient’s conditions in terms of age, comorbidity, and nutrition status as well as cancer stage and biomarkers.

This Special Issue on “Personalized Therapy and Clinical Outcome for lung Cancer” aims to provide recent information based on both translational studies and clinical trials. For this purpose, we invite investigators to submit original research articles and systematic reviews that will help readers to understand and develop personalized strategies for lung cancer treatment, including systemic therapy, surgery, and radiotherapy.

Dr. Atsushi Hata
Guest Editor

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Keywords

  • Lung cancer therapy
  • personalized therapy
  • targeted therapy
  • surgery
  • radiotherapy
  • molecular targeted drug
  • biomarkers
  • combination therapy

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Published Papers (1 paper)

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Review

16 pages, 5091 KiB  
Review
First-Line Anaplastic Lymphoma Kinase (ALK) Inhibitors for ALK-Positive Lung Cancer in Asian Populations: Systematic Review and Network Meta-Analysis
by Kuan-Li Wu, Hsiao-Ling Chen, Ying-Ming Tsai, Tai-Huang Lee, Hsiu-Mei Chang, Yu-Chen Tsai, Cheng-Hao Chuang, Yong-Chieh Chang, Yu-Kang Tu, Chih-Jen Yang, Jen-Yu Hung and Inn-Wen Chong
J. Clin. Med. 2021, 10(19), 4376; https://doi.org/10.3390/jcm10194376 - 25 Sep 2021
Cited by 9 | Viewed by 2597
Abstract
Various anaplastic lymphoma kinase inhibitors (ALKIs) have been approved for first-line use in treating anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). To date, no head-to-head comparison of these newer generation ALKIs has been made, and different efficacies of ALKIs may present [...] Read more.
Various anaplastic lymphoma kinase inhibitors (ALKIs) have been approved for first-line use in treating anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). To date, no head-to-head comparison of these newer generation ALKIs has been made, and different efficacies of ALKIs may present across ethnicity. This study aims to compare newer generation ALKIs for treatment efficacy in Asian groups using network meta-analysis. Phase II/III trials that enrolled treatment-naïve Asian ALK-rearranged NSCLC patients treated by ALKIs were included. Progression-free survival (PFS) and overall response rate (ORR) of each trial were extracted as indicators of drug efficacy. Surfaces under cumulative ranking curves (SUCRAs) were calculated as a numeric presentation of the overall ranking associated with each agent. After a systematic literature review, six phase III clinical trials were included. Our results showed that newer generation ALKIs, such as alectinib, brigatinib, ensartinib, and lorlatinib, all demonstrated superior efficacy to crizotinib. Among those, ensartinib exhibited the best overall SUCRA value and ranked first among all agents. According to our network meta-analysis, ensartinib may currently be the most effective first-line treatment for Asian patients with ALK-positive NSCLC. However, this conclusion needs further validation by a larger scale of clinical trials or posthoc analysis of Asian populations. Moreover, in our comparison, low-dose alectinib (300 mg twice daily) exhibited an efficacy profile similar to a higher dose regimen in Asian populations. Full article
(This article belongs to the Special Issue Personalized Therapy and Clinical Outcome for Lung Cancer)
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