Recent Advances in Osteoarthritis Management and Regenerative Strategies
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 44985
Special Issue Editors
Interests: osteoarthritis; musculoskeletal pathologies; cell-based therapies; mesenchymal stromal cells; ortho biological systems; 3D bioprinting; regenerative medicine
Special Issue Information
Dear Colleagues,
Osteoarthritis (OA) is one of the leading musculoskeletal diseases worldwide, with an enormous impact on patients’ daily life together with high costs for the health care system. Preclinical and clinical investigations showed the multi-coloured nature of OA based on complex molecular and cellular changes in the osteochondral unit, synovial membrane and meniscus. Cell-based therapies and other regenerative options showed promising effects in targeting molecular pathways involved in OA. Despite several advances in the last decades, many unsolved questions (e.g., cells versus no cells; optimal cell source and dosage; best delivery route; autologous versus allogenic treatment; etc.) remain challenging, leading to a lack of specific long-term therapies. Thus, there is a compelling demand for establishing new and mini-invasive treatment modalities to counteract OA evolution.
This special issue will give evidence on the progress of the state-of-the-art for OA care by outlining recent scientific updates for boosting clinical translation. We invite authors to propose original research and review articles, communications, and concept papers highlighting preclinical and clinical advances on relevant pathophysiological processes, models and therapeutic options to improve success in OA care. Potential topics include, but are not limited to:
- novel concepts on the crosstalk among joint tissue in OA setting;
- recent updates of the role of the synovial milieu on cartilage repair;
- recognition of new targets and biomarkers (e.g., extracellular vesicles, cytokines) as diagnostic tools;
- identification of peculiar and reliable in vitro and in vivo models mimicking OA microenvironment;
- preclinical studies estimating the regenerative capacity of original approaches;
- clinical studies presenting therapeutic procedures or personalized strategies for OA management.
Dr. Brunella Grigolo
Dr. Giovanna Desando
Guest Editors
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Keywords
- Osteoarthritis
- Osteochondral repair
- Synovial membrane
- Inflammation
- Hypertrophy
- Oxidative stress
- Cell-based therapy
- Tissue engineering
- 3D printing
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