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Clinical Advances in Chronic Obstructive Pulmonary Diseases in the Era...
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Clinical Advances in Chronic Obstructive Pulmonary Diseases in the Era of Precision Medicine

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1684

Special Issue Editors

Dr. Κonstantinos Bartziokas

E-Mail Website
Guest Editor
2nd Respiratory Medicine Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
Interests: asthma; COPD; pulmonology; lung disease
Special Issues, Collections and Topics in MDPI journals
Dr. Andriana I. Papaioannou

E-Mail Website
Guest Editor
1st Respiratory Department, Sotiria Chest Hospital, National and Kapodistrian University of Athens Medical School, 12462 Athens, Greece
Interests: spirometry; allergic diseases; pulmonology; lung diseases; asthma research; lung disease; chronic obstructive pulmonary disease; allergy

Special Issue Information

Dear Colleagues,

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD is complex and heterogeneous with respect to its aetiology, clinical presentation, phenotypes, and biological mechanisms. To address this complexity in clinical practice, and to move further toward personalized and precision medicine, a strategy based on the identification and treatment of so-called "treatable traits" has been proposed. There is an urgent need to identify COPD patients at high risk for poor outcomes and to understand at a mechanistic level why certain individuals are at high risk. Genetics, omics, and network analysis have begun to be used to unravel the heterogeneity of COPD and diagnose people with particular pathobiologies. Treating COPD patients according to their unique pathophysiological abnormalities and identifying high-risk individuals will become much easier with the availability of larger data sets, more omics, and new analytical techniques. These methods hold significant potential for COPD risk assessment, early intervention, medication repurposing, and the creation of innovative treatment strategies. This Special Issue will address precision medicine approaches, which focus on understanding an individual's disease risk, and tailoring management based on pathobiology, environmental exposures, and psychosocial issues. Therefore, to move this field forward, we invite original research, perspectives, and state-of-the-art reviews on clinical advances in COPD.

Dr. Κonstantinos Bartziokas
Dr. Andriana I. Papaioannou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized management
  • treatment
  • co-morbidities
  • COPD exacerbation
  • disease progression
  • mortality
  • pathogenesis
  • airway inflammation
  • biomarker

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Published Papers (2 papers)

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16 pages, 1490 KiB  
Article
Ex Vivo Lung Perfusion and Primary Graft Dysfunction Following Lung Transplantation: A Contemporary United Network for Organ Sharing Database Analysis
by Doug A. Gouchoe, Ervin Y. Cui, Divyaam Satija, Matthew C. Henn, Kukbin Choi, Justin P. Rosenheck, David R. Nunley, Nahush A. Mokadam, Asvin M. Ganapathi and Bryan A. Whitson
J. Clin. Med. 2024, 13(15), 4440; https://doi.org/10.3390/jcm13154440 - 29 Jul 2024
Viewed by 932
Abstract
Background: Primary graft dysfunction (PGD) has detrimental effects on recipients following lung transplantation. Here, we determined the contemporary trends of PGD in a national database, factors associated with the development of PGD grade 3 (PGD3) and ex vivo lung perfusion’s (EVLP) effect on [...] Read more.
Background: Primary graft dysfunction (PGD) has detrimental effects on recipients following lung transplantation. Here, we determined the contemporary trends of PGD in a national database, factors associated with the development of PGD grade 3 (PGD3) and ex vivo lung perfusion’s (EVLP) effect on this harmful postoperative complication. Methods: The United Network for Organ Sharing database was queried from 2015 to 2023, and recipients were stratified into No-PGD, PGD1/2, or PGD3. The groups were analyzed with comparative statistics, and survival was determined with Kaplan–Meier methods. Multivariable Cox regression was used to determine factors associated with increased mortality. PGD3 recipients were then stratified based on EVLP use prior to transplantation, and a 3:1 propensity match was performed to determine outcomes following transplantation. Finally, logistic regression models based on select criteria were used to determine risk factors associated with the development of PGD3 and mortality within 1 year. Results: A total of 21.4% of patients were identified as having PGD3 following lung transplant. Those with PGD3 suffered significantly worse perioperative morbidity, mortality, and had worse long-term survival. PGD3 was also independently associated with increased mortality. Matched EVLP PGD3 recipients had significantly higher use of ECMO postoperatively; however, they did not suffer other significant morbidity or mortality as compared to PGD3 recipients without EVLP use. Importantly, EVLP use prior to transplantation was significantly associated with decreased likelihood of PGD3 development, while having no significant association with early mortality. Conclusions: EVLP is associated with decreased PGD3 development, and further optimization of this technology is necessary to expand the donor pool. Full article
(This article belongs to the Special Issue Clinical Advances in Chronic Obstructive Pulmonary Diseases in the Era of Precision Medicine)
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10 pages, 1736 KiB  
Systematic Review
The Association Between Chronic Obstructive Pulmonary Disease (COPD) and Migraine: Systematic Review and Meta-Analysis
by Saleem Alshehri, Maha Saad Zain Al-Abeden, Mona Aldukain, Ali Aldukain, Dhai Almuteri, Assal Hobani, Abdulmalik Barakat and Nora Alzoum
J. Clin. Med. 2024, 13(22), 6944; https://doi.org/10.3390/jcm13226944 - 18 Nov 2024
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Abstract
Background/Objectives: Migraine and chronic obstructive pulmonary disease (COPD) are both common chronic conditions that may share underlying pathophysiological mechanisms despite presenting with distinct clinical features. Understanding the association between these two conditions could enhance treatment strategies and improve patient outcomes. This review [...] Read more.
Background/Objectives: Migraine and chronic obstructive pulmonary disease (COPD) are both common chronic conditions that may share underlying pathophysiological mechanisms despite presenting with distinct clinical features. Understanding the association between these two conditions could enhance treatment strategies and improve patient outcomes. This review aims to evaluate the relationship between COPD and migraine, highlighting shared risk factors and identifying gaps in the existing literature. Methods: A search was conducted across four electronic databases (PubMed, Ovid Medline, ScienceDirect, and Web of Science) following PRISMA guidelines up to January 2024. The search identified 85 studies, of which five met the inclusion criteria: observational studies, cohort studies, case–control studies, and randomized controlled trials examining the association between migraine and COPD. Studies not published in English and irrelevant study designs were excluded. The risk of bias was assessed using the JBI Critical Appraisal Tool, which evaluated aspects such as study design, participant selection, measurement methods, and the handling of confounding factors. Results: The review included five studies comprising 184,817 patients. All studies identified a significant association between COPD and migraine, with varying methodologies for diagnosing the conditions. Notably, COPD patients had an increased risk of migraine compared to controls, and migraine patients also demonstrated a higher risk of developing COPD. However, the evidence was marked by high heterogeneity and potential confounding factors. Conclusions: The findings suggest a significant association between COPD and migraine, potentially driven by shared mechanisms such as systemic inflammation. However, the predominance of cross-sectional studies limits causal inference. Future research should prioritize longitudinal studies to clarify the directionality and causality of the relationship between COPD and migraine while thoroughly addressing potential confounding factors. Full article
(This article belongs to the Special Issue Clinical Advances in Chronic Obstructive Pulmonary Diseases in the Era of Precision Medicine)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Outcomes and Histological Insights Following Lung Volume Reduction in COPD and Emphysema Patients
Authors: .
Affiliation: .

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