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Radiation-Induced Heart Diseases
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Radiation-Induced Heart Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 5480

Special Issue Editor

Prof. Dr. Maurizio Galderisi

E-Mail Website
Guest Editor
Department of Advanced Biomedical Science, University of Naples, Naples, Italy
Interests: study of the cardiovascular effects of oncological treatments; pathophysiology of cardiovascular diseases; evaluation of valvular pathologies; application of advanced echocardiography techniques (strain imaging; speckle tracking; 3d echocardiography)

Special Issue Information

Dear Colleagues,

Radiotherapy treatment is considered a valuable resource for the treatment of a broad range of solid tumors, such as breast, lung, and esophageal cancer and Hodgkin’s lymphoma. Nevertheless, radiation therapy usually includes ionizing radiation of the surrounding tissue that provides important side effects, especially involving the heart. Cardiovascular toxicity may impair long-term prognosis in cancer survivors. Consequently, careful watching of possible acute and long-term side effects should be a priority in this subset of patients. Indeed, the resulting cardiac disease may appear acutely but very often it develops several years after the irradiation. The main recognized cardiovascular complications related to radiotherapy include pericarditis, coronary artery disease, myocardial infarction, valvular heart disease, rhythm abnormalities, non-ischemic myocardial and conduction system damages, and peripheral artery diseases. Other than conventional cardiovascular risk factors, cumulative dose, daily fraction, and concomitant chemotherapy agents seem to influence the risk of cardiotoxicity after radiotherapy. Finally, it has to be considered that advances in the delivery of chest radiotherapy have reduced heart damage in patients undergoing radiotherapy.

The present Special Issue aims to give insight into the mentioned aspects of cardiovascular side-effects in radiation therapy, highlighting the importance of prevention, new diagnostic techniques to promptly assess cardiotoxicity and cardioprotective therapeutics, incorporating all the elements that are necessary to reduce mortality and morbidity of oncologic patients undergoing radiotherapy.

Prof. Dr. Maurizio Galderisi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Radiation therapy
  • Radiotherapy-induced cardiovascular disease
  • Cardiotoxicity
  • Cardiovascular prevention
  • Standard and advanced echocardiography
  • Cardioprotective therapeutics

Published Papers (2 papers)

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Research

16 pages, 2024 KiB  
Article
Relationship between Changes in Myocardial F-18 Fluorodeoxyglucose Uptake and Radiation Dose after Adjuvant Three-Dimensional Conformal Radiotherapy in Patients with Breast Cancer
by In Young Jo, Jeong Won Lee, Woo Chul Kim, Chul Kee Min, Eun Seog Kim, Seung-Gu Yeo and Sang Mi Lee
J. Clin. Med. 2020, 9(3), 666; https://doi.org/10.3390/jcm9030666 - 2 Mar 2020
Cited by 7 | Viewed by 2156
Abstract
This study aimed to assess the relationship between radiation dose and changes in the irradiated myocardial F-18 fluorodeoxyglucose (FDG) uptake after radiotherapy (RT) in breast cancer patients. The data of 55 patients with left and 48 patients with right breast cancer who underwent [...] Read more.
This study aimed to assess the relationship between radiation dose and changes in the irradiated myocardial F-18 fluorodeoxyglucose (FDG) uptake after radiotherapy (RT) in breast cancer patients. The data of 55 patients with left and 48 patients with right breast cancer who underwent curative surgical resection and adjuvant three-dimensional conformal RT and staging (PET1), post-adjuvant chemotherapy (PET2), post-RT (PET3), and surveillance (PET4) FDG positron emission tomography/computed tomography (PET/CT) were retrospectively reviewed. The median interval between PET1 and curative surgical resection, between the end of adjuvant chemotherapy and PET2, between the end of RT and PET3, and between the end of RT and PET4 were five days, 13 days, 132 days, and 353 days, respectively. The myocardial-to-blood pool uptake ratio was measured in all patients. For patients with left breast cancer, the 30 Gy- (30 Gy) and 47.5 Gy-irradiated myocardium-to-low-irradiated myocardium (47.5 Gy) FDG uptake ratios were additionally measured. There were no differences in the myocardial-to-blood pool uptake ratios between left and right breast cancer on all PET scans. For left breast cancer, higher 30 Gy and 47.5 Gy uptake ratios were observed on PET3 than on PET1 and PET2. Both uptake ratios decreased on PET4 compared to PET3, but, were still higher compared to PET1. On PET3 and PET4, the 47.5 Gy were higher than the 30 Gy uptake ratios, while there were no differences between them on PET1 and PET2. Although the whole myocardium FDG uptake showed no significant change, the irradiated myocardium FDG uptake significantly increased after RT and was related to radiation dose to the myocardium in breast cancer patients. These results might be an imaging evidence that supports the increased risk of heart disease after RT in patients with left breast cancer. Full article
(This article belongs to the Special Issue Radiation-Induced Heart Diseases)
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10 pages, 2187 KiB  
Article
Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy
by Marijana Tadic, Martin Genger, Cesare Cuspidi, Evgeny Belyavskiy, Athanasios Frydas, Aleksandar Dordevic, Daniel A. Morris, Jakob Völkl, Abdul Shokor Parwani, Burkert Pieske and Sabine Haßfeld
J. Clin. Med. 2019, 8(4), 421; https://doi.org/10.3390/jcm8040421 - 27 Mar 2019
Cited by 14 | Viewed by 3057
Abstract
We aimed to explore left atrial (LA) remodeling in the patients with solid cancer before initiation of chemo- or radiotherapy. This retrospective investigation included 92 chemo- and radiotherapy-naive cancer patients and 40 age- and gender-matched controls with a similar cardiovascular risk profile as [...] Read more.
We aimed to explore left atrial (LA) remodeling in the patients with solid cancer before initiation of chemo- or radiotherapy. This retrospective investigation included 92 chemo- and radiotherapy-naive cancer patients and 40 age- and gender-matched controls with a similar cardiovascular risk profile as the cancer group. All participants underwent comprehensive echocardiographic examination before the start of chemo- or radiotherapy. LA phasic function was evaluated in volumetric and strain method. Indexed minimal and pre-A LA volumes were significantly higher in the cancer patients. Total and passive LA emptying fraction (EF) were significantly lower, whereas active LAEF was significantly higher in the cancer patients. LA total longitudinal strain was significantly lower in the cancer patients. Strain rate analysis of LA phasic function showed that LA function during systole and early diastole was reduced in the cancer group, while it was increased during late diastole. These findings indicated that LA reservoir and conduit functions, assessed with LA volumetric and strain analysis, were deteriorated in the cancer group. On the other hand, LA booster pump function was elevated in the cancer group in comparison with the controls. In the whole population, cancer was associated with reduced LA total longitudinal strain independently of age, gender, BMI, LV hypertrophy, E/e’ ratio, diabetes, and hypertension. LA phasic function was impaired in the chemo- and radiotherapy-naive cancer patients in comparison with the control group. Cancer, LV hypertrophy, and hypertension were associated with reduced LA longitudinal strain independently of other important clinical parameters. Full article
(This article belongs to the Special Issue Radiation-Induced Heart Diseases)
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