Reprogramming Myeloid Cells in Cancer: A New Challenge in Medicine
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 9036
Special Issue Editor
Special Issue Information
Dear Colleagues,
Since the beginning of this decade, antitumor immunotherapy has been recognized as a potent treatment option for several solid cancers such as melanoma, lung, renal cell, head and neck, colorectal, liver, bladder, gastric, cervical, urothelial, and breast next to hematological malignancies. The most common within the immunotherapeutic arsenal is represented by the immune checkpoint inhibitors. So far, their efficacy has been linked to tumor mutational burden, tumor cell-specific checkpoint positivity, abundance of tumor-infiltrating T cells, and an immune evasion profile. However, several recent studies have reported on the dual role of tumor infiltrating myeloid cells (TIMs). Not only have their abundance and suppressive functions within the tumor microenvironment have been linked to tumor progression, they can be highly positive for certain immune checkpoints. In addition, their capacity to recognize monoclonal antibodies via their Fc-receptors has been linked to antibody-dependent cellular cytotoxicity as well as the phenomenon of hyper-progression. As such, research into the exact role of tumor-infiltrating myeloid cells as well as strategies that aim to reprogram the TIMs in order to enhance the overall therapeutic effect are of utmost importance to further advance the exciting field of antitumor immunotherapy.
Dr. Cleo Goyvaerts
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Cancer immunology
- Tumor micro-environment
- Tumor infiltrating myeloid cells
- Monocytes
- Macrophages
- Dendritic cells
- Granulocytes
- Mast cells
- Immune checkpoint inhibitors
- Targeting
- Repolarization
- Biomarkers
- Functional assays to measure functionality
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
