The Role of Autophagy in Cancer: Therapeutic Implications
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 2466
Special Issue Editor
Special Issue Information
Dear Colleagues,
Consistent with a physiological adaptive strategy to stressful conditions, disruption of autophagy was found to contribute to the pathogenesis of cancer. The molecular exploration of the significance of this cellular process for cancer development and progression that possesses an ambiguous dual role in reply to adverse stress events has only recently been initiated. As a physiological adaption to the frequently encountered apoptosis resistance in early phases of tumorigenesis, autophagy seems to resume a suppressive role that confines tumor necrosis and inflammation by the removal of cell damaging factors (e.g. oncoproteins), or even mediates cell death in malignant cells. During later stages of tumor development, autophagy appears to be reprogrammed by the cancer cell to prevent its elimination and support tumor progression. Here, autophagy provides cell survival factors and withdraws metabolic stress products that are particularly activated by pharmacological interference during cancer treatment. Increasing evidence also implicates an important role of autophagy in developing resistance to cancer therapeutics.
The underlying factors of the cell determining the protective or cytotoxic nature of the autophagic response are largely unclear, however. Nonetheless, it would be of crucial significance to affirm the context-dependent role of autophagy by previous investigation of the limiting molecular determinants for a positive therapeutic outcome. This special issue will therefore focus on new insights and address regulatory molecular mechanisms of autophagy that suppress or promote cancer development.
Dr. Carlo Rodolfo
Guest Editor
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Keywords
- Autophagy
- Cancer
- Dual role
- Cell death
- Molecular determinants
- Tumor-suppressive
- Tumor-promoting
- Apoptosis resistance
- Therapy resistance
- Cancer therapy
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