Tricuspid Regurgitation: From Pathophysiology to New Therapeutic Approaches
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".
Deadline for manuscript submissions: 25 January 2025 | Viewed by 2816
Special Issue Editor
2. Fundación Interhospitalaria para la Investigación Cardiovascular (FIC), Calle Profesor Martín Lagos s/n, 28040 Madrid, Spain
Interests: echocardiography; cardiac imaging; clinical cardiology; cardiac function; cardiomyopathies; magnetic resonance; cardiovascular disease; heart failure; myocardial infarction
Special Issue Information
Dear Colleagues,
Following the surge of new catheter-based therapies, the tricuspid valve is no longer considered the forgotten valve. An in-depth review of the tricuspid valve anatomy was conducted to implement these new treatments and there is already initial data from clinical trials about their prognostic relevance. However, several aspects regarding tricuspid regurgitation mechanisms and evolution need to be clarified. We already know that tricuspid regurgitation is not as benign as previously believed. Nevertheless, surgical repair has been classically associated with high in-hospital mortality. Therefore, new criteria are needed to optimize the patient selection and timing for intervention. Moreover, due to the growing number of percutaneous treatment options and the increasing interest in surgical repair improvements, selection of the best therapeutic approach for each patient is required. Cardiac imaging may shed light on these aspects, incluing attaining a better understanding of the right ventricular volume overload management, refining key anatomic features for intervention timing and personalization, and predicting posprocedural functional and clinical response, among others. Thus, this Special Issue will encompass all recent advances in tricuspid regurgitation management, with a specific focus on imaging diagnosis.
Dr. Eduardo Pozo Osinalde
Guest Editor
Manuscript Submission Information
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Keywords
- tricuspid regurgitation
- right ventricular function
- heart failure
- cardiac imaging
- surgical repair and replacement
- percutaneous intervention
- prognosis
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: New therapeutic advances in the management of tricuspid valve regurgitation
Authors: Andreas Synetos; Nikolaos Ktenopoulos; Odysseas Katsaros; Konstantina Vlasopoulou; Theofanis Korovesis; Maria Drakopoulou; Anastasios Apostolos; Leonidas Koliastasis; Konstantinos Toutouzas; Constantinos Tsioufis
Affiliation: Hippocration General Hospital
Abstract: For original research articles, systematic reviews and meta-analyses, the abstract should be an objective representation of the article and consist of about 250 words. It must not contain results that have not been substantiated in the main text and should not exaggerate the main conclusion. The abstract should be structured to contain the following headings. Background/Objectives: highlight the purpose of the study, introduce your research question(s), and the context surrounding them. Methods: describe the main methods or treatments applied, highlighting any unique characteristics of the participant/patient samples. Include any relevant preregistration numbers. Clinical trials should include details that CONSORT has identified as essential. Results: summarize the article's main findings. Conclusions: describe the main takeaways and interpretations of the study. For other article type, such as Reviews, a 200 word unstructured abstract should be included.
Title: Assessment of tricuspid regurgitation by cardiac magnetic resonance imaging: current role and future applications
Authors: Lobke L. Pype; Blanca Domenech-Ximenos; Bernard P. Paelinck; Nicole Sturkenboom; Caroline M. Van De Heyning
Affiliation: Antwerp University Hospital, University of Antwerp
Abstract: Tricuspid regurgitation (TR) is a prevalent valvular disease with a significant mortality rate. Evaluation of TR severity and associated right heart remodeling and dysfunction is crucial to determine the optimal therapeutic strategy and to improve prognosis. While echocardiography remains the first-line imaging technique to evaluate TR, it has many limitations, both operator- and patient-related. Cardiovascular magnetic resonance imaging (CMR) has emerged as an innovative and comprehensive non-invasive cardiac imaging technique, with additional value beyond routine echocardiographic assessment. Besides its established role as the gold standard for evaluation of cardiac volumes, CMR can add important insights with regard to valvular anatomy and function. Accurate quantification of TR severity, including calculation of regurgitant volume and fraction, can be performed using either the well-known indirect volumetric method or novel 4D Flow imaging. In addition, CMR can be used to assess the impact on the right heart, including right heart remodeling, function and tissue characterization. Several CMR derived parameters have been associated with outcome, highlighting the importance of multi-modality imaging in patients with TR. The aim of this review is to provide an overview of the current role of CMR in assessment and management of patients with TR, and of its future applications.