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Coronary Heart Disease: Causes, Diagnosis and Management
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Coronary Heart Disease: Causes, Diagnosis and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 1510

Special Issue Editor

Dr. Andrea Denegri

E-Mail Website
Guest Editor
Cardiology Division, Parma University Hospital, 43125 Parma, Italy
Interests: acute coronary syndromes; inflammation; interventional cardiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are currently working on a Special Issue of the Journal of Clinical Medicine, focusing on coronary heart disease. Despite remarkable progress being made in recent decades, coronary heart disease is still the leading cause of morbidity and mortality worldwide, representing a major public health issue, with a huge impact in terms of costs and quality of life. Great research efforts are needed to improve the diagnosis and treatment of this disease.

From pathophysiology to assessment and management, we aim to offer readers an overview of the latest advances in the field and to examine the most intriguing challenges and expected developments that may impact our daily clinical practice.

Therefore, we encourage you to submit to this Special Issue, providing additional insights on the causes, diagnosis, and management of coronary heart disease, considering emerging evidences in pharmacological therapies, invasive and non-invasive tools for the identification and stratification of patients who may benefit from coronary revascularization and technical advancements in percutaneous and surgical revascularization, particularly for complex high-risk procedures.

We very much look forward to receiving your contributions to this exciting project.

Dr. Andrea Denegri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary heart disease
  • coronary revascularization
  • coronary artery disease
  • ischemic heart disease
  • atherosclerosis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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32 pages, 1844 KiB  
Article
Relationship Between Inflammatory Readings and the Degree of Coronary Atherosclerosis (Pilot Study)
by Agnė Liuizė (Abramavičiūtė), Aušra Mongirdienė and Jolanta Laukaitienė
J. Clin. Med. 2025, 14(1), 122; https://doi.org/10.3390/jcm14010122 - 28 Dec 2024
Cited by 2 | Viewed by 980
Abstract
Background/Objectives: Some calculated total blood count readings are investigated as novel additional readings to help with evaluation of personalized CAD patients’ clinical management and prognosis. We aimed to investigate the association between readings such as NLR, MLR, PLR, NMR, LMR, MHR, SII, and [...] Read more.
Background/Objectives: Some calculated total blood count readings are investigated as novel additional readings to help with evaluation of personalized CAD patients’ clinical management and prognosis. We aimed to investigate the association between readings such as NLR, MLR, PLR, NMR, LMR, MHR, SII, and SIRI and the severity of CAD in patients with SAP. Methods: This retrospective pilot study included 166 patients. All patients underwent CA or CCTA, or both, to assess severity of CAD. Patients were divided three ways: (1) according to presence (n = 146) or absence (n = 20) of CAD; (2) according to Gensini score; (3) according to the CAD-RADS score. Results: Patients with CAD had lower LMR, higher NLR, SIRI, MLR, and SII compared to patients without CAD (p < 0.001 and p = 0.018, respectively for SII). According to the CAD severity by Gensini score, the NLR, MLR, SII, and SIRI values increase and LMR decreases gradually with severity of CAD (p < 0.001). A moderate correlation was found between SII (r = 0.511, p < 0.001), NLR (r = 0.567, p < 0.001), and SIRI (r = 0.474, p < 0.001) and severity of CAD according to Gensini score. MLR and LMR had a low corelation with severity of CAD according to Gensini score (r = 0.356, p < 0.001; r = −0.355, p < 0.001, respectively). The CAD-RADS score weakly correlated with NLR and MHR (r = 0.365, p < 0.001; r = 0.346, p < 0.001, respectively), and moderately with LMR, MLR, and SIRI (r = −0.454, p < 0.001; r = 0.455, p < 0.001; r = 0.522, p < 0.001, respectively). Conclusions: NLR, LMR, and SIRI appear to be potential predictors of chronic inflammation, and SIRI is the best predictor of the degree of atherosclerosis of all the other assessed blood parameters. Full article
(This article belongs to the Special Issue Coronary Heart Disease: Causes, Diagnosis and Management)
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Review

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21 pages, 2640 KiB  
Review
Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis
by Makhabbat Bekbossynova, Timur Saliev, Tatyana Ivanova-Razumova, Saltanat Andossova, Aknur Kali and Gulzhan Myrzakhmetova
J. Clin. Med. 2025, 14(7), 2352; https://doi.org/10.3390/jcm14072352 - 29 Mar 2025
Viewed by 248
Abstract
Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, traditionally linked to elevated cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C). However, despite aggressive lipid-lowering strategies, residual cardiovascular risk persists, underscoring the need to explore additional contributing factors. This review examines emerging [...] Read more.
Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, traditionally linked to elevated cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C). However, despite aggressive lipid-lowering strategies, residual cardiovascular risk persists, underscoring the need to explore additional contributing factors. This review examines emerging risk factors beyond cholesterol, including chronic inflammation, gut microbiota composition, oxidative stress, and environmental exposures. Inflammation plays a pivotal role in atherogenesis, with markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) serving as indicators of disease activity. The gut microbiome, particularly metabolites like trimethylamine N-oxide (TMAO), has been implicated in vascular inflammation and plaque development, while beneficial short-chain fatty acids (SCFAs) demonstrate protective effects. Oxidative stress further exacerbates endothelial dysfunction and plaque instability, driven by reactive oxygen species (ROS) and lipid peroxidation. Additionally, environmental factors, including air pollution, heavy metal exposure, endocrine disruptors, and chronic psychological stress, have emerged as significant contributors to cardiovascular disease. Understanding these novel risk factors offers a broader perspective on atherosclerosis pathogenesis and provides new avenues for targeted prevention and therapeutic interventions. Full article
(This article belongs to the Special Issue Coronary Heart Disease: Causes, Diagnosis and Management)
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