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Clinical Updates in the Management of Ventricular Tachycardia
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Clinical Updates in the Management of Ventricular Tachycardia

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (20 October 2021) | Viewed by 6282

Special Issue Editor

Dr. Pasquale Vergara

E-Mail Website
Guest Editor
Department of Arrhythmology and Cardiac Electrophysiology, San Raffaele Scientific Institute, Milan, Italy
Interests: electrophysiology; catheter ablation; VT ablation; SCD; ACM; MVP

Special Issue Information

Dear Colleagues,

I am very pleased to invite you to this Special Issue of the Journal of Clinical Medicine on “Clinical Updates in the Management of Ventricular Tachycardia”. The scope of this Issue is to provide insights on clinical approaches to ventricular tachycardia. Particular focus will be given to current imaging techniques for pathophysiological characterization, diagnosis, and procedural planning in different etiologies. Attention will be paid to recent progresses in the field of cardiac magnetic resonance. Furthermore, a multimodality approach to risk stratification of arrhythmic cardiac death will be provided, especially in challenging subgroups like patients with preserved left ventricle ejection fraction. Light will be shed on contemporary pharmacological therapies and recent technological advances in the ablation of ventricular tachycardia. The growing body of knowledge about the pathophysiology and the risk stratification can allow us to more precisely target the arrhythmic substrate and to introduce the topic of tailored, patient-centered therapies such as ICD in primary prevention.

Dr. Pasquale Vergara
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ventricular tachycardia
  • sudden cardiac death
  • catheter ablation
  • antiarrhythmic drugs
  • cardiac magnetic resonance
  • risk stratification
  • ICD
  • ischemic cardiomyopathy
  • nonischemic cardiomyopathy
  • arrhythmogenic cardiomyopathy

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Published Papers (2 papers)

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Research

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10 pages, 1670 KiB  
Article
Appropriate ICD Interventions for Ventricular Arrhythmias Are Predicted by Higher Syntax Scores I and II in Patients with Ischemic Heart Disease
by Teresa Strisciuglio, Giuseppe Ammirati, Valerio Pergola, Lucio Addeo, Maria Angela Losi, Aniello Viggiano, Livio Imparato, Vincenzo Russo, Enrico Melillo, Gerardo Nigro, Giuseppe Stabile, Antonio D’Onofrio, Giovanni Esposito and Antonio Rapacciuolo
J. Clin. Med. 2021, 10(9), 1843; https://doi.org/10.3390/jcm10091843 - 23 Apr 2021
Cited by 1 | Viewed by 1689
Abstract
Aims. The occurrence of ventricular arrhythmias (VAs) in ischemic heart disease (IHD) patients is related to the presence and extent of fibrotic/scar tissue. As coronary atherosclerosis is the underlying cause of myocardial ischemia and fibrosis, in IHD patients implanted with an implantable cardioverter [...] Read more.
Aims. The occurrence of ventricular arrhythmias (VAs) in ischemic heart disease (IHD) patients is related to the presence and extent of fibrotic/scar tissue. As coronary atherosclerosis is the underlying cause of myocardial ischemia and fibrosis, in IHD patients implanted with an implantable cardioverter defibrillator (ICD) we investigated the relation between the VA burden and the complexity of coronary atherosclerotic lesions. Methods and results. In IHD patients who underwent coronary angiography and ICD implant, the Syntax scores I and II (SSI-II), as index of the severity of the coronary atherosclerotic disease, and the occurrence of VA were assessed. Overall 144 patients were included (123 males). Of these 22 patients (15%) experienced at least one episode of VA (cycle length 298 ± 19 msec) that required ICD intervention. The number of episodes per patient and per year was 4 ± 6 and 2.8 ± 4, respectively. Patients that experienced a VA compared to those free from arrhythmic events did not have distinct baseline clinical characteristics except for a higher SS I and SS II (21 (IQR 13–38) vs. 16 (IQR 10–23); p = 0.037; and 50 (IQR 39–62) vs. 42 (IQR 34–50); p = 0.012). In the binary logistic regression analyses the SS I and II were the only independent predictors of VA occurrence. A higher SS II was also associated with an earlier time to first event (p = 0.005). Conclusion. Higher SS I-II scores reflect a more severe coronary atherosclerosis and are associated with a greater VA burden. Further studies are needed to better clarify the ability of SSI-II to stratify the risk of IHD patients to develop life-threatening VA. Full article
(This article belongs to the Special Issue Clinical Updates in the Management of Ventricular Tachycardia)
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Review

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18 pages, 6745 KiB  
Review
Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification
by Luigi Pannone, Giulio Falasconi, Lorenzo Cianfanelli, Luca Baldetti, Francesco Moroni, Roberto Spoladore and Pasquale Vergara
J. Clin. Med. 2021, 10(9), 1823; https://doi.org/10.3390/jcm10091823 - 22 Apr 2021
Cited by 10 | Viewed by 4205
Abstract
Sudden cardiac death (SCD) is the leading cause of cardiovascular mortality in patients with coronary artery disease without severe systolic dysfunction and in heart failure with preserved ejection fraction. From a global health perspective, while risk may be lower, the absolute number of [...] Read more.
Sudden cardiac death (SCD) is the leading cause of cardiovascular mortality in patients with coronary artery disease without severe systolic dysfunction and in heart failure with preserved ejection fraction. From a global health perspective, while risk may be lower, the absolute number of SCDs in patients with left ventricle ejection fraction >35% is higher than in those with severely reduced left ventricle ejection fraction (defined as ≤35%). Despite these observations and the high amount of available data, to date there are no clear recommendations to reduce the sudden cardiac death burden in the population with mid-range or preserved left ventricle ejection fraction. Ongoing improvements in risk stratification based on electrophysiological and imaging techniques point towards a more precise identification of patients who would benefit from ICD implantation, which is still an unmet need in this subset of patients. The aim of this review is to provide a state-of-the-art approach in sudden cardiac death risk stratification of patients with mid-range and preserved left ventricular ejection fraction and one of the following etiologies: ischemic cardiomyopathy, heart failure, atrial fibrillation or myocarditis. Full article
(This article belongs to the Special Issue Clinical Updates in the Management of Ventricular Tachycardia)
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