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Insights on Cancer Diagnosis, Treatment and Side Effects Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 30 January 2026 | Viewed by 563

Special Issue Editors


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Guest Editor
1. Department II, University of Medicine and Pharmacy "Carol Davila" Bucharest, 020021 Bucharest, Romania
2. Department of Surgery 3, “Prof. Dr. Al. Trestioreanu” Institute of Oncology, 022338 Bucharest, Romania
Interests: oncologic surgery; hepato-biliopancreatic surgery; endocrine surgery
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
2. “Prof. Dr. Al. Trestioreanu” Oncology Discipline, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: external beam radiotherapy; brachytherapy; radiobiology; radiophysics; image-guided radiotherapy; stereotactic radiotherapy; radiosurgery
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. "Prof. Dr. Alexandru Trestioreanu" Oncology and Palliative care Discipline, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
2. Medical Oncology II Department, "Prof. Dr. Alexandru Trestioreanu" Oncology Institute, 022328 Bucharest, Romania
Interests: breast cancer; cervical cancer; biomarkers; hereditary cancers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The landscape of oncology continues to evolve through meaningful progress in diagnosis, treatment, and supportive care. This Special Issue, “Insights on Cancer Diagnosis, Treatment and Side Effects Management,” invites contributions from all areas of cancer research and clinical practice that reflect the multidisciplinary nature of modern oncology.

We are seeking original articles and reviews that explore improvements in diagnostic accuracy and therapeutic strategies—including systemic therapies, surgery, radiotherapy, and emerging modalities—as well as approaches to managing the side effects and complications of treatment. Special attention will be given to work that fosters integration between specialties and enhances the patient-centered approach to cancer care.

This Special Issue aims to create a platform for sharing evidence-based insights and innovations that contribute to better outcomes and quality of life for individuals affected by cancer.

We look forward to your valuable contributions.

Dr. Octav Ginghină
Dr. Mihai-Teodor Georgescu
Dr. Laurentia Nicoletta Gales
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer diagnosis
  • cancer treatment
  • side effects management
  • oncology
  • personalized medicine
  • supportive care

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Published Papers (1 paper)

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Research

14 pages, 1193 KB  
Article
Impact of Chemoradiotherapy on Quality of Life in Cervical Cancer Patients: A Prospective Cohort Study
by Maria-Alexandra Barbu, Miruna Ghigeanu, Sarah Bahaa-Eddin, Alexandru Michire, Alexandra Hanu, Gentiana Eremia, Ianina Draganescu, Alina Birca and Mihai-Teodor Georgescu
J. Clin. Med. 2025, 14(17), 6023; https://doi.org/10.3390/jcm14176023 - 26 Aug 2025
Viewed by 386
Abstract
Background: Cervical cancer is considered to be a global health challenge, particularly in low- and middle-income countries. Romania reports one of the highest burdens in Europe due to limited access to screening and HPV vaccination. Chemoradiotherapy is standard for locally advanced disease, [...] Read more.
Background: Cervical cancer is considered to be a global health challenge, particularly in low- and middle-income countries. Romania reports one of the highest burdens in Europe due to limited access to screening and HPV vaccination. Chemoradiotherapy is standard for locally advanced disease, but the impact on quality of life (QoL) for a low- and middle-income population has not yet been explored. This study aims to evaluate the effect of chemoradiotherapy on the QoL of cervical cancer survivors in the Romanian population. Methods: This prospective observational study included 111 patients with stage I–IV cervical cancer undergoing chemoradiotherapy. QoL was assessed using the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire before, during, and after treatment. Demographic and clinical data were collected. The statistical analyses included t-tests, ANOVA, and linear mixed-effects models to evaluate changes over time and the influence of sociodemographic and treatment-related factors. Results: FACT-G scores significantly increased after treatment, with improvements in physical and functional well-being. Better before-treatment QoL was associated with urban residence, early-stage disease, marital status, and higher education. Among treatment toxicities, only nausea had a statistically significant negative effect on QoL during treatment, while other toxicities showed no significant impact. Conclusions: Chemoradiotherapy in cervical cancer patients was not associated with a substantial deterioration in quality of life during treatment and was followed by significant improvement after therapy completion. These findings highlight a favorable short-term QoL trajectory and emphasize the need for longitudinal studies to assess whether such benefits are maintained over the long term. Full article
(This article belongs to the Special Issue Insights on Cancer Diagnosis, Treatment and Side Effects Management)
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