Effects of Local Anesthetics

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 5581

Special Issue Editor


E-Mail Website
Guest Editor
Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany
Interests: anesthesiology; local anesthetics; inflammation; cancer; pulmonary vasculature

Special Issue Information

Dear Colleagues,

The Journal of Clinical Medicine (JCM) is supporting the publication of a Special Issue on the “Effects of Local Anesthetics”, for which I will serve as Guest Editor.

Local anesthetics have been used in clinical anesthesia for more than 100 years and are still among the most important drugs of our specialty. Besides their well-known—and extensively studied—“old” effects on the voltage-gated sodium channels, the drugs might exert several additional effects, from which our patients might benefit tremendously. These “new” effects might include various anti-inflammatory effects, e.g., on the endothelium or in the pathogenesis of pain, but also antimetastatic effects on malignant cells.

The Special Issue aims to promote research on this topic. By providing the opportunity to publish a serious number of articles on this important issue in modern anesthesiology, we hope we will be able to enhance the readers’ ability to appreciate the research and intensify their potential gain of knowledge.
I would therefore kindly invite you to submit your original research work or review articles—either referring to the “old” or the “new” effects of the drugs—to the JCM in order to get published in our Special Issue after a thorough peer-review by experts in the field.
I am very much looking forward to working with you on this Special Issue.

Sincerely,

Prof. Dr. Tobias Piegeler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Local anesthetics
  • Inflammation
  • Anesthesia and cancer
  • Enhanced recovery
  • Pain
  • Mechanism
  • Outcome.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

7 pages, 606 KiB  
Article
Influence of General and Local Anesthesia on Postoperative Pain after Impacted Third Molar Surgery
by Jeong-Kui Ku, Jae-Young Kim, Mi-Kyoung Jun, Yeong Kon Jeong and Jong-Ki Huh
J. Clin. Med. 2021, 10(12), 2674; https://doi.org/10.3390/jcm10122674 - 17 Jun 2021
Cited by 2 | Viewed by 2063
Abstract
This study examined the effects of general anesthesia on the postoperative pain level after third molar extractions compared to local anesthesia. This retrospective study included patients who underwent four simultaneous third molar extractions under general or local anesthesia and had records of their [...] Read more.
This study examined the effects of general anesthesia on the postoperative pain level after third molar extractions compared to local anesthesia. This retrospective study included patients who underwent four simultaneous third molar extractions under general or local anesthesia and had records of their postoperative pain levels (visual analog scale, VAS). The pain level was determined in the early (Postoperative day; POD < #3) and late (POD #3-7) periods. The operation time and recently modified difficulty index were analyzed to validate the homogenous condition of the extraction. Of the 227 male inpatients (aged 20.9 ± 1.3 years), 172 and 55 patients underwent third molar extractions under local and general anesthesia, respectively. The age and difficulty index were distributed equally, but the operation time was longer in general anesthesia than in local anesthesia (p < 0.001). The early and late periods featured similar pain outcomes. The operation time correlated with the total periods with a correlation coefficient of 0.271 (p < 0.001). In conclusion, the postoperative pain following whole third molar extraction was related to the operation time rather than the anesthetic methods. Full article
(This article belongs to the Special Issue Effects of Local Anesthetics)
Show Figures

Figure 1

Review

Jump to: Research

15 pages, 1046 KiB  
Review
Local Anesthetics and Recurrence after Cancer Surgery-What’s New? A Narrative Review
by Sarah D. Müller, Jonathan S. H. Ziegler and Tobias Piegeler
J. Clin. Med. 2021, 10(4), 719; https://doi.org/10.3390/jcm10040719 - 11 Feb 2021
Cited by 14 | Viewed by 2969
Abstract
The perioperative use of regional anesthesia and local anesthetics is part of almost every anesthesiologist’s daily clinical practice. Retrospective analyses and results from experimental studies pointed towards a potential beneficial effect of the local anesthetics regarding outcome—i.e., overall and/or recurrence-free survival—in patients undergoing [...] Read more.
The perioperative use of regional anesthesia and local anesthetics is part of almost every anesthesiologist’s daily clinical practice. Retrospective analyses and results from experimental studies pointed towards a potential beneficial effect of the local anesthetics regarding outcome—i.e., overall and/or recurrence-free survival—in patients undergoing cancer surgery. The perioperative period, where the anesthesiologist is responsible for the patients, might be crucial for the further course of the disease, as circulating tumor cells (shed from the primary tumor into the patient’s bloodstream) might form new micro-metastases independent of complete tumor removal. Due to their strong anti-inflammatory properties, local anesthetics might have a certain impact on these circulating tumor cells, either via direct or indirect measures, for example via blunting the inflammatory stress response as induced by the surgical stimulus. This narrative review highlights the foundation of these principles, features recent experimental and clinical data and provides an outlook regarding current and potential future research activities. Full article
(This article belongs to the Special Issue Effects of Local Anesthetics)
Show Figures

Figure 1

Back to TopTop