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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Dual Diagnosis to Dual Disorder(s): Bridging Comorbidity and Integrated Clinical Understanding

edited by

Angelo G. I. Maremmani

submission deadline 20 Jul 2026 | 4 articles | Viewed by 3488 | Submission Open

Keywords: dual diagnosis; dual disorder; psychiatric comorbidity; addiction; integrated care; self-medication; substance use; mental illness; treatment models

(This special issue belongs to the Section Mental Health)

Acute Coronary Syndrome(ACS): From Emergency Intervention to Long-Term Prevention

edited by Marco Ciardetti and Alessio Mattesini

submission deadline 20 Jul 2026 | 2 articles | Viewed by 3350 | Submission Open

Keywords: acute coronary syndrome; primary percutaneous coronary intervention; antithrombotic therapy; secondary prevention; risk stratification

(This special issue belongs to the Section Cardiology)

Advances in Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis

edited by

Roberto Carbone

submission deadline 20 Jul 2026 | 2 articles | Viewed by 3154 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; idiopathic pulmonary fibrosis; heart failure; mitral valve disease

(This special issue belongs to the Section Respiratory Medicine)

Advances in Hepatitis: Prevention, Treatment, and Global Health Impact

edited by

Michał Brzdęk

Dorota Zarębska-Michaluk

and

Krystyna Dobrowolska

submission deadline 20 Jul 2026 | 4 articles | Viewed by 3023 | Submission Open

Keywords: hepatitis B; hepatitis C; liver disease; direct-acting antivirals (DAAs); global health; public health policy; viral hepa-titis elimination; health disparities; cirrhosis; vaccination programs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Obesity-Related Metabolic and Cardiovascular Disorders

edited by

Lucia Frittitta

and Federica Vinciguerra

submission deadline 20 Jul 2026 | 4 articles | Viewed by 3022 | Submission Open

Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Innovative Aspects in Dental Implantology and Related Clinical Research (Second Edition)

edited by

Carlo Barausse

and

Gerardo Pellegrino

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2935 | Submission Open

Keywords: dental implants; implantology; bone regeneration; implant-supported prosthesis; zygomatic implants; reconstructive surgery; pre-implant surgery; short implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Challenges and Advances in Periodontology and Oral Surgery: 2nd Edition

edited by

Glauco Chisci

submission deadline 20 Jul 2026 | 3 articles | Viewed by 2853 | Submission Open

Keywords: oral surgery; third molar; periodontitis; antibiotics; infection; pain; research; advances; complications; dental implants; bone regeneration; maxillofacial surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in the Management of Chronic Cough and Severe Asthma

edited by Ebymar Arismendi

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2838 | Submission Open

Keywords: asthma; chronic cough; biomarkers; exacerbations; biologics; precision medicine; airway inflammation; pediatric asthma

(This special issue belongs to the Section Respiratory Medicine)

Ocular Surface Disease: Epidemiology, Diagnosis and Management

edited by

Sandeep K. Dhallu

and

Nicole Carnt

submission deadline 20 Jul 2026 | 3 articles | Viewed by 2835 | Submission Open

Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies

(This special issue belongs to the Section Ophthalmology)

Insights on Cancer Diagnosis, Treatment and Side Effects Management

edited by

Octav Ginghină

Mihai-Teodor Georgescu

and

Laurentia Nicoleta Gales

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2775 | Submission Open

Keywords: cancer diagnosis; cancer treatment; side effects management; oncology; personalized medicine; supportive care

(This special issue belongs to the Section Oncology)

Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes

edited by Ivan Krečak, Marko Skelin and Zinaida Perić

submission deadline 20 Jul 2026 | 3 articles | Viewed by 2759 | Submission Open

Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis

(This special issue belongs to the Section Hematology)

Innovations in Interventional Cardiology: Advancing Minimally Invasive Cardiac Care

edited by

Konstantinos Stathogiannis

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2757 | Submission Open

Keywords: TAVI; TAVR; MTEER; TTEER; TTVR; ASD; PFO; IVUS; OCT

(This special issue belongs to the Section Cardiology)

Advances in Pacemaker Implantation: Past, Present, and Future Challenges

edited by Rahul N. Doshi and

Ankur A. Karnik

submission deadline 20 Jul 2026 | 1 articles | Viewed by 2699 | Submission Open

Keywords: pacing; physiologic pacing; left bundle area pacing; leadless pacing; lead management

(This special issue belongs to the Section Cardiology)

Aortic Valve Disease: Current Evolution and Future Opportunities

edited by Gianluigi Perri

submission deadline 20 Jul 2026 | 3 articles | Viewed by 2618 | Submission Open

Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease

(This special issue belongs to the Section Cardiology)

Trauma Surgery: Strategies, Challenges and Vision of the Future

edited by

Shai Factor

and Yaniv S. Warschawski

submission deadline 20 Jul 2026 | 3 articles | Viewed by 2565 | Submission Open

Keywords: orthopaedic surgery; fractures; injuries; upper limb; trauma

(This special issue belongs to the Section Clinical Research Methods)

New Clinical Perception of Cardiac Rehabilitation

edited by

Antonello D’Andrea

and Mario Pacileo

submission deadline 20 Jul 2026 | 3 articles | Viewed by 2469 | Submission Open

Keywords: cardiac rehabilitation; digital health; exercise therapy; cardiovascular prevention; chronic disease management; psychosocial support; personalized medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition

edited by

Pablo Demelo-Rodríguez

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2414 | Submission Open

Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis

(This special issue belongs to the Section Hematology)

Paradigms, Advances and Future Directions in Oral Medicine

edited by

Pia Lopez-Jornet

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2370 | Submission Open

Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

State of the Art in Spinal Cord Injuries: Clinical Rehabilitation and Management

edited by

Valerio Pisani

submission deadline 20 Jul 2026 | 4 articles | Viewed by 2248 | Submission Open

Keywords: neurorehabilitation; assistive technologies; neuroplasticity; neuromodulation; spinal cord injury

(This special issue belongs to the Section Clinical Rehabilitation)

The Optimal Hybrid Revascularization Approach for Multilevel Peripheral Arterial Disease

edited by

Jin Hyun Joh

submission deadline 20 Jul 2026 | 1 articles | Viewed by 2238 | Submission Open

Keywords: peripheral arterial disease; revascularization; endovascular procedure; endarterectomy; limb salvage; patency; hybrid procedures; lower extremity; stents; angioplasty

(This special issue belongs to the Section Vascular Medicine)

Current Advances in Non-Trauma Emergency Critical and Resuscitation Medicine

edited by

Sebastian Bergrath

submission deadline 20 Jul 2026 | Viewed by 2139 | Submission Open

Keywords: resuscitation; non-trauma critically ill; emergency department; resuscitation room management; neuro-critical emergency care; emergency department critical care

(This special issue belongs to the Section Emergency Medicine)

Advances in Perioperative Anesthesia: Emerging Techniques and Clinical Practices

edited by Mitchell H. Tsai, Matthew Bergeron Allen and Roya Saffary

submission deadline 20 Jul 2026 | 3 articles | Viewed by 2103 | Submission Open

Keywords: perioperative medicine; goal-concordant care; anesthesia co-management; postoperative outcomes; perioperative anesthesia

(This special issue belongs to the Section Anesthesiology)

Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications

edited by

Petroula N. Nana

, Tilo Kölbel and José Ignacio F. Torrealba

submission deadline 20 Jul 2026 | 4 articles | Viewed by 2059 | Submission Open

Keywords: aortic aneurysm; aortic dissection; genetic aortic disease; acute aortic syndromes; endovascular repair; complica-tions; outcomes

(This special issue belongs to the Section Vascular Medicine)

Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine: 2nd Edition

edited by

Carlos Escobar

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2013 | Submission Open

Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)

Neuro-Cardiology: An Obligation for Combined Care of Stress and Heart Diseases

edited by Mario J. Garcia and

Fatih Yalcin

submission deadline 20 Jul 2026 | 1 articles | Viewed by 2010 | Submission Open

Keywords: neuro-cardiology; cardiovascular; segmental remodeling; stressors; hypertension; triple S

(This special issue belongs to the Section Cardiology)

Clinical Updates in Fractures: Orthopedics, Trauma Surgery, and Rehabilitation

edited by

Rahul Vaidya

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1986 | Submission Open

Keywords: orthopedic surgery; global orthopedic health; surgical techniques; outreach; inreach; artificial intelligence; robotics; outcome measures

(This special issue belongs to the Section Orthopedics)

Clinical Advances in Prenatal Diagnosis and Fetal Therapy

edited by

Mar Bennasar

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1968 | Submission Open

Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations

(This special issue belongs to the Section Obstetrics & Gynecology)

Artificial Intelligence and Machine Learning in Clinical Practice

edited by Theodosis Kalamatianos and

Ioannis Kakkos

submission deadline 20 Jul 2026 | 3 articles | Viewed by 1921 | Submission Open

Keywords: artificial intelligence in healthcare; medical image/signal analysis; clinical decision support systems; predictive analytics; personalized medicine; explainable AI; diagnosis; prognosis

(This special issue belongs to the Section General Surgery)

Pre-Hospital and In-Hospital Emergency Care Research

edited by

Marcus Eng Hock Ong

Fahad Javaid Siddiqui

and Yohei Okada

submission deadline 20 Jul 2026 | 3 articles | Viewed by 1892 | Submission Open

Keywords: pre-hospital; in-hospital; emergency care; emergency medical services; acute care

(This special issue belongs to the Section Emergency Medicine)

Integrating Artificial Intelligence into Plastic, Reconstructive, and Aesthetic Surgery: Innovations, Challenges, and Clinical Application

edited by

Roberto Cuomo

and

Gianluca Marcaccini

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1774 | Submission Open

Keywords: plastic; reconstructive; aesthetic surgery; artificial intelligence; AI in plastic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Outcomes in Bipolar and Depressive Disorders

edited by

Luca J. Steardo

and Francesco Monaco

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1709 | Submission Open

Keywords: mood disorders; clinical outcomes; treatment response; psychopathology; pathophysiology

(This special issue belongs to the Section Mental Health)

Clinical Diagnosis and Treatment in Oncology: Radiotherapy and Imaging Analysis

edited by

Giuseppe Ferrera

Pierpaolo Alongi

and

Francesco Cuccia

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1703 | Submission Open

Keywords: radiomics; metabolic imaging; radiotherapy; predictive factors; response models; PET-CT; artificial intelligence; biomarkers; machine-learning

(This special issue belongs to the Section Oncology)

Recent Management of Hip Fractures

edited by

Toshiyuki Kawai

submission deadline 20 Jul 2026 | 3 articles | Viewed by 1662 | Submission Open

Keywords: hip fracture; internal fixation; hemiarthroplasty; arthroplasty and fixation; osteoporosis management; fracture prevention; multidisciplinary care; surgical treatment; rehabilitation strategies

(This special issue belongs to the Section Orthopedics)

Recent Advances and Future Perspectives of Subarachnoid Hemorrhage

edited by Alexandros Doukas and Athanasios K. Petridis

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1648 | Submission Open

Keywords: subarachnoid hemorrhage; neuromonitoring; neurocritical care; neurointerventions; neurointensive care

(This special issue belongs to the Section Clinical Neurology)

Reducing Modifiable Risk Factors to Prevent and Control Non-Communicable Diseases: 2nd Edition

edited by

Daniele Piovani

and

Gisella Figlioli

submission deadline 20 Jul 2026 | 3 articles | Viewed by 1583 | Submission Open

Keywords: non-communicable disease; chronic disease; cardiovascular disease; cancer; chronic respiratory disease; diabetes; mental health; tobacco use; physical inactivity; unhealthy diet; alcohol use; disease prevention

(This special issue belongs to the Section Epidemiology & Public Health)

Spine Surgery: Clinical Advances and Practice Updates

edited by

Junho Song

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1376 | Submission Open

Keywords: spine surgery; minimally invasive spine surgery; endoscopic spine surgery; robotics; artificial intelligence; spinal deformity; scoliosis; spinal trauma

(This special issue belongs to the Section Orthopedics)

Advances in Chronic Pain Research and Therapy

edited by Elena Makovac

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1305 | Submission Open

Keywords: chronic pain; pain perception; brain-body interactions; therapeutic effectiveness; integrated approach

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Clinical Management of Temporomandibular Joint Diseases

edited by

João Luiz Monteiro

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1286 | Submission Open

Keywords: minimally invasive surgical procedure; artificial intelligence; temporomandibular joint disorders; temporomandibular disorders; temporomandibular joint

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cardiopulmonary Resuscitation in the Emergency Care Unit

edited by

Martín Otero-Agra

, Felipe Fernández-Méndez,

Myriam Santos-Folgar

and

María Fernández-Méndez

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1243 | Submission Open

Keywords: cardiopulmonary resuscitation; advanced life support; new technologies; special circumstances; emergency care unit

(This special issue belongs to the Section Emergency Medicine)

Diagnosis, Treatment and Prognosis of Head and Neck Cancer

edited by

Armando De Virgilio

and Elena Russo

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1156 | Submission Open

Keywords: head and neck neoplasms; surgical procedures; minimally invasive surgical procedures; radiotherapy; immunotherapy; biomarkers; treatment outcome; early diagnosis; prognosis; quality of life

(This special issue belongs to the Section Oncology)

Pulmonary Disease and Comorbidities, Clinical and Epidemiological Studies: From Neonates to Adults

edited by

Roxana Maria Nemes

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1149 | Submission Open

Keywords: pulmonary disorders; comorbidity; neonatal lung disease; pediatric pulmonology; adult respiratory disease; chronic respiratory conditions; clinical epidemiology; pulmonary function testing; diagnostic imaging; lung biomarkers; risk factors

(This special issue belongs to the Section Respiratory Medicine)

Colorectal Cancer: Early Detection, Treatment Advances and Patient Outcomes

edited by

Damiano Caputo

Roberto Cammarata

and Federica Giordano

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1131 | Submission Open

Keywords: colorectal cancer; early detection; prevention; innovation; screening; precision medicine; biomarkers; genetic profile

(This special issue belongs to the Section Oncology)

Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome

edited by

Maria Amicone

and

Antonio Pisani

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1128 | Submission Open

Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet

(This special issue belongs to the Section Nephrology & Urology)

Echocardiography in Clinical Cardiac Imaging: Advances and Emerging Applications

edited by

Marina Leitman

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1117 | Submission Open

Keywords: echocardiography; cardiac Imaging; speckle-tracking echocardiography; artificial intelligence; myocardial function; valvular heart disease; precision cardiology

(This special issue belongs to the Section Cardiology)

Clinical Challenges in Heart Failure Management: 2nd Edition

edited by Paolo Severino, Gaetano M. Ruocco and

Andrea D'Amato

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1116 | Submission Open

Keywords: acute heart failure; chronic heart failure; inotropic support; left ventricular assist device; cardiac contractility modulation; guanylate cyclase stimulators; quality of life; telemedicine; palliative care

(This special issue belongs to the Section Cardiology)

Early Diagnosis and Treatment of Hepatitis B and C: Bridging Innovation and Implementation

edited by

Rawi Hazzan

and

Fadi Abu Baker

submission deadline 20 Jul 2026 | 2 articles | Viewed by 1110 | Submission Open

Keywords: hepatitis B virus (HBV); hepatitis C virus (HCV); hepatitis delta virus (HDV); early diagnosis; viral hepatitis elimination; functional cure; direct-acting antivirals (DAAs); antiviral therapy; treatment adherence; care cascade; screening programs; health policy

(This special issue belongs to the Section Infectious Diseases)

Current Status and Future of Urological Surgery

edited by

Filippo Marino

, Davide De Marchi and

Luca Di Gianfrancesco

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1041 | Submission Open

Keywords: urological surgery; robotic-assisted surgery; minimally invasive surgery; artificial intelligence; augmented reality; surgical navigation; endourology; laparoscopic urology; reconstructive urology; functional urology; bph treatment; urinary incontinence; prostate cancer surgery; bladder cancer surgery; surgical innovation; digital surgery

(This special issue belongs to the Section Nephrology & Urology)

Minimally Invasive Spine Surgery: Evidence, Advances and Controversies

edited by

Miltiadis Georgiopoulos

, Constantine Constantoyannis,

Mark A. MacLean

and Oliver Lasry

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1041 | Submission Open

Keywords: spine surgery; minimally invasive; MIS; MISS; endoscopic; tubular; fusion; laminectomy; discectomy; decompression; percutaneous; robotic; robotic-assisted; navigation; augmented-reality

(This special issue belongs to the Section Clinical Neurology)

Current Challenges in Adult Congenital Heart Diseases

edited by

Agata Bielecka-Dabrowa

submission deadline 20 Jul 2026 | 2 articles | Viewed by 999 | Submission Open

Keywords: adult congenital heart disease; quality of life; pregnancy in congenital heart disease; heart failure; arrhythmia; septal defect; congenital valve stenosis; coarctation of the Aorta; Fontan circulation; Tetralogy of Fallot

(This special issue belongs to the Section Cardiology)

Novel Perspectives in Transcatheter Aortic Valve Implantation

edited by Nay Min Htun

submission deadline 20 Jul 2026 | 1 articles | Viewed by 966 | Submission Open

Keywords: TAVI; life-time management; TAVI-in-TAVI; bicuspid valve; pure aortic regurgitation; small annuli

(This special issue belongs to the Section Cardiology)

Displaying special issue 501-550 on page 11 of 32.

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