SPECT and PET Imaging of Small Animals Volume 2nd Edition

A special issue of Journal of Imaging (ISSN 2313-433X). This special issue belongs to the section "Medical Imaging".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1468

Special Issue Editors


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Guest Editor
PET/CT Department and Small Animal PET/CT Unit, Centre for Clinical Research, Experimental Surgery & Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), GR-11527 Athens, Greece
Interests: iterative reconstruction algorithms in PET; medical image processing; radiomics; clinical and preclinical PET/CT
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Research Center of Mathematics, Academy of Athens, GR-11527 Athens, Greece
Interests: mathematical methods in medical image reconstruction; analytic reconstruction methods for PET and SPECT; emission tomography
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Research Center of Mathematics, Academy of Athens, GR-11527 Athens, Greece
Interests: PET and SPECT imaging; small-animal imaging; multimodality imaging; molecular imaging; image reconstruction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past two decades, there has been a great demand for dedicated small-animal imaging systems for biomedical research applications. Several commercial and research small-animal imaging systems have recently emerged, including PET, PET/CT, and PET/MR, as well as SPECT and SPECT/CT scanners. These small-animal imaging modalities are powerful tools providing crucial biological and physiological information to researchers. Non-invasive in vivo imaging of small animals has become an important tool in biomedical research.

There are many preclinical applications of small-animal PET and SPECT systems, for example, in the areas of cardiology, neurology, and oncology. Small-animal imaging focuses on the study of various diseases like cancer, with a tremendous impact on applications such as drug development. Furthermore, small-animal imaging systems facilitate the monitoring of pharmacological and therapeutic intervention for these diseases. In recent years, there has been an increased demand for improved drug development and for in vivo monitoring of internal organs’ morphological and functional characteristics. In this direction, there are several aspects of medicine that can be thoroughly explored by microPET and microSPECT systems, including diagnosis and novel therapeutic interventions. Therefore, therapeutics, clinical trials, and translational research can greatly benefit from small-animal imaging. The future of small-animal imaging lies in the upgrade of relevant hardware and software, in the development of novel applications, and in the improvement of camera sensitivity, spatial resolution, and sophisticated image reconstruction.

The aim of this Special Issue is to present novel and diverse research articles that demonstrate new instrumentation developments, imaging protocols, reconstruction algorithms, and imaging applications in small-animal PET and SPECT imaging. This is not limited to special application areas.

Dr. Anastasios Gaitanis
Dr. Nicholas E. Protonotarios
Dr. George Kastis
Guest Editors

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Keywords

  • small-animal imaging (i.e., PET- and SPECT-based scanners, instrumentation)
  • small-animal imaging applications (i.e., drug discovery, quantification)
  • radionuclide imaging
  • imaging protocols
  • image reconstruction
  • image processing
  • radiomics

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Published Papers (1 paper)

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13 pages, 789 KiB  
Article
Noninvasive Quantification of Glucose Metabolism in Mice Myocardium Using the Spline Reconstruction Technique
by Alexandros Vrachliotis, Anastasios Gaitanis, Nicholas E. Protonotarios, George A. Kastis and Lena Costaridou
J. Imaging 2024, 10(7), 170; https://doi.org/10.3390/jimaging10070170 - 16 Jul 2024
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Abstract
The spline reconstruction technique (SRT) is a fast algorithm based on a novel numerical implementation of an analytic representation of the inverse Radon transform. The purpose of this study was to compare the SRT, filtered back-projection (FBP), and the Tera-Tomo 3D algorithm for [...] Read more.
The spline reconstruction technique (SRT) is a fast algorithm based on a novel numerical implementation of an analytic representation of the inverse Radon transform. The purpose of this study was to compare the SRT, filtered back-projection (FBP), and the Tera-Tomo 3D algorithm for various iteration numbers, using small-animal dynamic PET data obtained from a Mediso nanoScan® PET/CT scanner. For this purpose, Patlak graphical kinetic analysis was employed to noninvasively quantify the myocardial metabolic rate of glucose (MRGlu) in seven male C57BL/6 mice (n=7). All analytic reconstructions were performed via software for tomographic image reconstruction. The analysis of all PET-reconstructed images was conducted with PMOD software (version 3.506, PMOD Technologies LLC, Fällanden, Switzerland) using the inferior vena cava as the image-derived input function. Statistical significance was determined by employing the one-way analysis of variance test. The results revealed that the differences between the values of MRGlu obtained via SRT versus FBP, and the variants of he Tera-Tomo 3D algorithm were not statistically significant (p > 0.05). Overall, the SRT appears to perform similarly to the other algorithms investigated, providing a valid alternative analytic method for preclinical dynamic PET studies. Full article
(This article belongs to the Special Issue SPECT and PET Imaging of Small Animals Volume 2nd Edition)
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