Diabetes Mellitus: Current Research and Future Perspectives 2nd Edition

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 752

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Pediatric Unit, S. Chiara Hospital, 38122 Trento, Italy
Interests: diabetology; pediatric endocrinology; nutrition; obesity; bone metabolism
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Special Issue Information

Dear Colleagues,

The heterogeneity in age at onset and clinical presentation within the same form of diabetes, differences in the response to treatments in patients with the same phenotype, and the variability in the course of the disease require personalized management. The precision medicine approach has been applied to individuals with monogenic diabetes (i.e., MODY, neonatal diabetes) and to type 1 and type 2 diabetes to select treatments that are most likely to offer benefits and least likely to cause side effects, with improvement of clinical outcomes and economic cost saving.

In the last 10 years, genetic, metabolomic, immunologic, and other sophisticated tests have become less expensive and more widespread; therefore, it is expected that precision medicine will become increasingly applied to diabetes care.

This Special Issue of Journal of Personalized Medicine aims to highlight the current state of precision medicine applied to diabetes to show some of the latest findings and future perspectives and integrate expertise from basic science, clinical, and population-based approaches. Topics of interest include novel insights into gene testing, polymorphisms and bioinformatics, metabolites and intestinal microbiome analysis, as well as their association with the risk of disease, drug metabolism, or disease complications.

Dr. Roberto Franceschi
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes treatment
  • drug metabolism
  • disease complications
  • polymorphisms
  • epigenetics
  • metabolomics
  • proteomics

Published Papers (1 paper)

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Research

16 pages, 425 KiB  
Article
Coffee Consumption and CYP1A2 Polymorphism Involvement in Type 2 Diabetes in a Romanian Population
by Laura Claudia Popa, Simona Sorina Farcas and Nicoleta Ioana Andreescu
J. Pers. Med. 2024, 14(7), 717; https://doi.org/10.3390/jpm14070717 - 3 Jul 2024
Viewed by 530
Abstract
Cytochrome P450 1A2 (CYP1A2) is known to be the main enzyme directly responsible for caffeine metabolism. Rs762551 (NC_000015.10:g.74749576C>A) is a single nucleotide polymorphism of the CYP1A2 gene, and it is known mainly for metabolizing caffeine. A significant worldwide health issue, type 2 diabetes [...] Read more.
Cytochrome P450 1A2 (CYP1A2) is known to be the main enzyme directly responsible for caffeine metabolism. Rs762551 (NC_000015.10:g.74749576C>A) is a single nucleotide polymorphism of the CYP1A2 gene, and it is known mainly for metabolizing caffeine. A significant worldwide health issue, type 2 diabetes (T2DM), has been reported to be negatively associated with coffee consumption. Yet, some studies have proven that high intakes of coffee can lead to a late onset of T2DM. Objectives: This study aims to find any significant correlations among CYP1A2 polymorphism, coffee consumption, and T2DM. Methods: A total of 358 people were enrolled in this study—218 diagnosed with T2DM, and 140 representing the control sample. The qPCR technique was performed, analyzing rs762551 (assay C_8881221) on the LightCycler 480 (Roche, Basel, Switzerland) with Gene Scanning software version 1.5.1 (Roche). Results: Our first observation was that the diabetic patients were likely to consume more coffee than the non-diabetic subjects. People with the AA genotype, or the fast metabolizers, are the least common, yet they are the highest coffee consumers and present the highest glucose and cholesterol levels. Another important finding is the correlation between coffee intake and glucose level, which showed statistically significant differences between the diabetic group (p = 0.0002) and the control group (p = 0.029). Conclusions: The main conclusion of this study is that according to genotype, caffeine levels, glucose, and cholesterol are interconnected and proportionally related, regardless of type 2 diabetes. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Exploring the relationship between insulin resistance and restrictive lung diseases in type 2 diabetes: A study on lifestyle interventions and risk factors
Authors: Mani Roshan #1,2, Christian Mudrack #1, Alba Sulaj1,2, Ekaterina von Rauchhaupt1, Lukas Seebauer1,2, Elisabeth Kliemank1,2, Zoltan Kender1,2, Julia Szendroedi1,2, Stefan Kopf1,2
Affiliation: 1Department of Endocrinology, Diabetology, Metabolism and Clinical Chemistry (Internal Medicine 1), Heidelberg University Hospital, Heidelberg, Germany. 2German Center for Diabetes Research (DZD).

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