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Clinical Updates and Challenges of Multiple Sclerosis and Related Disorders
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Clinical Updates and Challenges of Multiple Sclerosis and Related Disorders

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2232

Special Issue Editor

Dr. Maddalena Sparaco

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Guest Editor
Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
Interests: multiple sclerosis; demyelinating disease of the central nervous system

Special Issue Information

Dear Colleagues,

Multiple Sclerosis (MS) and related disorders are defined by their debated pathophysiology, diverse clinical presentations and different disease courses. Recent advancements in understanding the pathophysiology of MS, emerging diagnostic techniques, novel imaging modalities, and cutting-edge biomarkers hold the potential to facilitate early and accurate diagnosis, to comprehend the course of disease, evaluate the impact of comorbidities on disease progression, and assess the role of prognostic factors. Additionally, the focus on patient-reported outcomes, the evolving landscape of disease-modifying therapies, rehabilitation strategies, and multidisciplinary approaches should enhance the management of clinical aspects and ensure a good quality of life for people with MS, moving toward personalized medicine in the management of MS.

This Special Issue aims to comprehensively explore the current landscape of MS and related disorders by providing a source for in-depth clinical updates and discussions on the challenges associated with diagnosis, management, treatment of disease, and the psychosocial dimensions of living with MS. By spotlighting these challenges, this Special Issue will foster an interdisciplinary dialogue to identify gaps in the knowledge and areas in need of further research.

Dr. Maddalena Sparaco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiple sclerosis
  • demyelinating disease of the central nervous
  • progression
  • patient reported outcomes
  • biomarkers
  • therapeutic approaches
  • monitoring strategies

Published Papers (2 papers)

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Research

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15 pages, 387 KiB  
Article
Investigating the Potential Influence of TAS2R16 Genetic Variants and Protein Levels on Multiple Sclerosis Development
by Greta Gedvilaite, Enrika Pileckaite, Ignas Ramanauskas, Loresa Kriauciuniene, Renata Balnyte and Rasa Liutkeviciene
J. Pers. Med. 2024, 14(4), 402; https://doi.org/10.3390/jpm14040402 - 10 Apr 2024
Viewed by 512
Abstract
The study aimed to investigate the association between the TAS2R16 gene (rs860170, rs978739, rs1357949), TAS2R16 serum levels, and multiple sclerosis (MS). A total of 265 healthy control subjects and 218 MS patients were included in the study. Single nucleotide polymorphisms (SNPs) were tested [...] Read more.
The study aimed to investigate the association between the TAS2R16 gene (rs860170, rs978739, rs1357949), TAS2R16 serum levels, and multiple sclerosis (MS). A total of 265 healthy control subjects and 218 MS patients were included in the study. Single nucleotide polymorphisms (SNPs) were tested by real-time polymerase chain reaction (RT-PCR). The serum concentration of TAS2R16 was measured using the ELISA method. Analyses revealed that the TAS2R16 rs860170 TT genotype was statistically significantly less frequent in the MS group than in the control group (p = 0.041), and the CC genotype was statistically significantly more frequent in the MS group than in the control group (p < 0.001). In the most robust (codominant) model, the CC genotype was found to increase the odds of MS by ~27-fold (p = 0.002), and each C allele increased the odds of MS by 1.8-fold (p < 0.001). Haplotype analysis of the rs860170, rs978739, and rs1357949 polymorphisms showed that the C-C-A haplotype was associated with a ~12-fold increased odds of MS occurrence (p = 0.02). Serum TAS2R16 levels were elevated in the MS group compared to control subjects (p = 0.014). Conclusions: The rs860170, rs978739, and rs1357949 polymorphisms demonstrated that the C-C-A haplotype and elevated TAS2R16 serum levels can promote the development of MS. These preliminary findings underscore the importance of specific genetic variants, such as rs860170, rs978739, and rs1357949, in MS risk. Additionally, elevated TAS2R16 serum levels in MS patients suggest a potential role in MS pathogenesis. These findings provide insights into the genetic and molecular mechanisms underlying MS and pave the way for personalized diagnostic and therapeutic strategies. Integrating genetic and serum biomarker data in MS research offers promising avenues for improving clinical outcomes and advancing precision medicine approaches in the future. Full article
(This article belongs to the Special Issue Clinical Updates and Challenges of Multiple Sclerosis and Related Disorders)
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Review

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12 pages, 882 KiB  
Review
Posterior Tibial Nerve Stimulation for the Treatment of Detrusor Overactivity in Multiple Sclerosis Patients: A Narrative Review
by Vaia Sapouna, Athanasios Zikopoulos, Sofia Thanopoulou, Dimitrios Zachariou, Ioannis Giannakis, Aris Kaltsas, Bou Sopheap, Nikolaos Sofikitis and Athanasios Zachariou
J. Pers. Med. 2024, 14(4), 355; https://doi.org/10.3390/jpm14040355 - 28 Mar 2024
Viewed by 1510
Abstract
Bladder dysfunction, particularly neurogenic detrusor overactivity (DO), poses a substantial challenge in multiple sclerosis (MS) patients, detrimentally impacting their quality of life (QoL). Conventional therapies often fall short, necessitating alternative approaches like posterior tibial nerve stimulation (PTNS) for effective management. This narrative review [...] Read more.
Bladder dysfunction, particularly neurogenic detrusor overactivity (DO), poses a substantial challenge in multiple sclerosis (MS) patients, detrimentally impacting their quality of life (QoL). Conventional therapies often fall short, necessitating alternative approaches like posterior tibial nerve stimulation (PTNS) for effective management. This narrative review critically examines the application of PTNS in treating DO among MS patients, aiming to provide a comprehensive synthesis of its efficacy, underlying mechanisms, and clinical outcomes. By evaluating a spectrum of studies, including randomized controlled trials and long-term follow-up research, the review elucidates PTNS’s role in enhancing bladder control and ameliorating symptoms of urgency and incontinence, thereby improving patient well-being. Despite its potential, the review acknowledges the limited scope of existing research specific to MS-induced neurogenic DO and calls for further investigation to optimize PTNS protocols and understand its long-term benefits. Highlighting PTNS’s minimal invasiveness and favorable safety profile, the review advocates for its consideration as a viable third-line treatment option in MS-related bladder dysfunction management. Through this analysis, the review contributes to the broader narrative of seeking effective, patient-centered therapeutic strategies for MS-related complications, underscoring the importance of personalized care in improving patient outcomes. Full article
(This article belongs to the Special Issue Clinical Updates and Challenges of Multiple Sclerosis and Related Disorders)
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