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Advances in the Research of Endocrine and Metabolic Disorders in...
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Advances in the Research of Endocrine and Metabolic Disorders in the Human Reproductive System

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1627

Special Issue Editors

Dr. Kuan-Hao Tsui

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Interests: infertility; free radical biology; aging; precision medicine; endocrine
Dr. Chia-Jung Li

E-Mail Website
Co-Guest Editor
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Interests: mitochondrial medicine; free radical biology; reproduction; cancer biology; chronic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infertility is a disease of the reproductive system, with endocrine and metabolic abnormalities being the most common cause of reproductive disorders. There are still many unknown mechanisms of reproductive endocrine and metabolic abnormalities. Reproductive endocrine and metabolic disorders are centrally regulated by the hypothalamus. Hypothalamic metabolism affects hormonal imbalance, and hormonal imbalance and energy depletion lead to changes in metabolic pathways and impairment of the interrelationship between energy metabolism and reproduction. Reproductive health is affected by energy status, which in turn changes metabolic pathways and hormone levels. The primary goal is to gain sufficient knowledge from multi-omics to develop future diagnostic and therapeutic procedures to improve human reproductive health.

The purpose of this Special Issue is to dig deeper into the multifaceted research affecting infertility and to lay the theoretical foundation for individualized medicine. Both original manuscripts and reviews discussing genomic, transcriptomic, epigenomic, proteomic, and metabolomic abnormalities related to reproductive physiology in human and animal models are highly welcome.

Dr. Corinne Frere
Guest Editor

Dr. Chia-Jung Li
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Reproduction
  • Infertility
  • Transcriptomics
  • Epigenomics
  • Proteomics
  • Endocrine
  • Metabolism
  • Follicular microenvironment
  • Gynecological endocrinology
  • Assisted reproduction technology
  • Endometriosis
  • Multi-omics

Published Papers (1 paper)

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Research

11 pages, 1931 KiB  
Article
Intravascular Laser Blood Irradiation (ILIB) Enhances Antioxidant Activity and Energy Metabolism in Aging Ovaries
by Li-Te Lin, Chia-Jung Li, Chyi-Uei Chern, Pei-Hsuan Lin, Po-Wen Lin, Yu-Chen Chen, Hsiao-Wen Tsai and Kuan-Hao Tsui
J. Pers. Med. 2024, 14(6), 551; https://doi.org/10.3390/jpm14060551 - 22 May 2024
Viewed by 846
Abstract
Background: Ovarian aging is characterized by the accumulation of free radicals, leading to tissue damage and affecting reproductive health. Intravascular laser irradiation of blood (ILIB, using a low-energy He-Ne laser) is known for its efficacy in treating vascular-related diseases by reducing free radicals [...] Read more.
Background: Ovarian aging is characterized by the accumulation of free radicals, leading to tissue damage and affecting reproductive health. Intravascular laser irradiation of blood (ILIB, using a low-energy He-Ne laser) is known for its efficacy in treating vascular-related diseases by reducing free radicals and inflammation. However, its impact on ovarian aging remains unexplored. This study aimed to investigate the effects of ILIB on oxidative stress and energy metabolism in aging ovaries. Methods: Genetic analysis was conducted on 75 infertile patients with aging ovaries, divided into ILIB-treated and control (CTRL) groups. Patients underwent two courses of laser treatment, and clinical parameters were evaluated. Cumulus cells were collected for the genetic analysis of oxeiptosis, glycolysis, and the tricarboxylic acid (TCA) cycle. Results: The analysis of gene expression patterns revealed intriguing findings in ILIB-treated patients compared to the untreated group. Notably, ILIB treatment resulted in significant upregulation of oxeiptosis-related genes AIFM1 and NRF2, suggesting a potential protective effect against oxidative stress-induced cell death. Furthermore, ILIB treatment led to a downregulation of glycolysis-associated gene hexokinase 2 (HK2), indicating a shift away from anaerobic metabolism, along with an increase in PDHA levels, indicative of enhanced mitochondrial function. Consistent with these changes, ILIB-treated patients exhibited elevated expression of the key TCA cycle genes citrate synthase (CS), succinate dehydrogenase complex subunit A (SDHA), and fumarate hydratase (FH), signifying improved energy metabolism. Conclusion: The findings from this study underscore the potential of ILIB as a therapeutic strategy for mitigating ovarian aging. By targeting oxidative stress and enhancing energy metabolism, ILIB holds promise for preserving ovarian function and reproductive health in aging individuals. Further research is warranted to elucidate the underlying mechanisms and optimize the application of ILIB in clinical settings, with the ultimate goal of improving fertility outcomes in women experiencing age-related ovarian decline. Full article
(This article belongs to the Special Issue Advances in the Research of Endocrine and Metabolic Disorders in the Human Reproductive System)
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