The Origin of Biomolecules on the Early Earth at Volcanic Hydrothermal Settings

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Origin of Life".

Deadline for manuscript submissions: closed (28 July 2023) | Viewed by 2916

Special Issue Editors

Lehrstuhl für Strukturelle Membranbiochemie, Fakultät Chemie, Technische Universität München, Lichtenbergstr. 4, 85748 Garching, Germany
Interests: origin of life, transition metal sulfides; catalysis, hydrothermal conditions; acetylene; carbon fixation; chemical evolution; early metabolism;

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Co-Guest Editor
Systems Biophysics, Physics Department, Center for Nanoscience, Ludwig-Maximilians-Universität München, Amalienstraße 54, 80799 Munich, Germany
Interests: thermophoresis; origin of life; non-equilibrium physics; hydrothermal systems; UV lesions; microfluidics; molecular evolution

Special Issue Information

Dear Colleagues,

The formation of biomolecules is an indispensable prerequisite for the emergence of life on Earth. Simple monomeric biomolecules provide the basis for the further evolution of more complex biomolecules, which are essential for extant biochemistry and life as we know it.

Concerning the origin of such biomolecules, different habitats and conditions have been discussed in the scientific community, but there is no consensus about even the principal questions: terrestrial origin or initiated through meteoritic impacts, hot or cold origin, UV radiation or not, tidal or deep-sea conditions, acidic or alkaline pH values, and so on.

Volcanic hydrothermal settings on early Earth constitute one of the possible habitats for the formation of biomolecules from inorganic precursors. Metal minerals like iron, nickel and cobalt, including their sulfides, are abundant in Earth´s crust and could act as catalytic surfaces in the aqueous environment. Hydrothermal exhalations deliver a constant flow of simple, gaseous substrates like CO2, CO, acetylene, H2, H2S, HCN, and NH3 as substrates for the formation of simple organic molecules. High pressure and temperature could promote carbon fixation reactions and the early evolution of important biomolecules. Temperature and pH gradients in hydrothermal fluid flows as well as different bonding strength to the mineral surface allow selectivity and trigger reaction pathways to ever more complex biomolecules.

It seems striking that in extant biochemistry iron and nickel sulfide clusters still play an important role in catalyzing carbon fixation and hydrogenation reactions. This could inform further exploration of these scenarios in the search for the emergence of life.

In this Special Issue we highlight all aspects of biomolecule formation under hydrothermal conditions.

Scientific perspectives, research or review articles are encouraged for submission.

Dr. Claudia Huber
Dr. Christof B. Mast
Guest Editors

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Published Papers (1 paper)

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10 pages, 1829 KiB  
Perspective
Template-Directed Replication and Chiral Resolution during Wet–Dry Cycling in Hydrothermal Pools
by David Ross and David Deamer
Life 2023, 13(8), 1749; https://doi.org/10.3390/life13081749 - 15 Aug 2023
Viewed by 985
Abstract
The commonly supposed template-based format for RNA self-replication requires both duplex assembly and disassembly. This requisite binary provision presents a challenge to the development of a serviceable self-replication model since chemical reactions are thermochemically unidirectional. We submit that a solution to this problem [...] Read more.
The commonly supposed template-based format for RNA self-replication requires both duplex assembly and disassembly. This requisite binary provision presents a challenge to the development of a serviceable self-replication model since chemical reactions are thermochemically unidirectional. We submit that a solution to this problem lies in volcanic landmasses that engage in continuous cycles of wetting and drying and thus uniquely provide the twofold state required for self-replication. Moreover, they offer conditions that initiate chain branching, and thus furnish a path to autocatalytic self-replication. The foundations of this dual thermochemical landscape arise from the broad differences in the properties of the bulk water phase on the one hand, and the air/water interfacial regions that emerge in the evaporative stages on the other. With this reaction system as a basis and employing recognized thermochemical and kinetic parameters, we present simulations displaying the spontaneous and autocatalyzed conversion of racemic and unactivated RNA monomers to necessarily homochiral duplex structures over characteristic periods of years. Full article
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