Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1114

Special Issue Editors


E-Mail Website1 Website2
Guest Editor
Department of Functional Genomics, Medical University of Lodz, 90-752 Lodz, Poland
Interests: carcinogenesis; gene expression regulation; molecular mechanisms; transcription factors
Special Issues, Collections and Topics in MDPI journals

E-Mail Website1 Website2
Guest Editor
1. Department of Biomedicine and Experimental Surgery, Medical University of Lodz, 90-136 Lodz, Poland
2. Department of Functional Genomics, Medical University of Lodz, 90-752 Lodz, Poland
Interests: cancer; neurology; in vitro; genetics; transcription factors
Special Issues, Collections and Topics in MDPI journals
1. Department of Biomedicine and Experimental Surgery, Medical University of Lodz, 90-136 Lodz, Poland
2. Department of Functional Genomics, Medical University of Lodz, 90-752 Lodz, Poland
Interests: carcinogenesis, functional genomics; high-throughput sequencing; in silico; transcription factors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the first volume of this Special Issue being a great success (https://www.mdpi.com/journal/life/special_issues/Therapeutic_Effect), we are very pleased to announce the second volume of our Special Issue titled “Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition”. Despite significant progress in diagnosis and treatment, cancer remains the biggest challenge of modern medicine. The rapid advancement in molecular technologies and new sophisticated bioinformatic analytic methods have introduced novel therapeutic perspectives. This fuels hope for overcoming the major issues associated with drug treatment, such as cancer heterogeneity or multidrug resistance. We cordially invite you to present your outstanding cancer-drug-related discoveries in this Special Issue to the wider scientific and academic community.

In this Special Issue, we would like to present a collection of articles, such as reviews and systematic reviews, original papers, clinical trials, molecular and bioinformatics studies.

We are looking forward to your submission.

Dr. Elżbieta Janina Płuciennik
Dr. Żaneta Kałuzińska-Kołat
Dr. Damian Kołat
Guest Editors

Manuscript Submission Information

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Keywords

  • cancer
  • therapy
  • cancer drug
  • molecular mechanism
  • signaling pathways
  • targeted therapy
  • in silico drug response studies
  • innovative cancer treatment

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Published Papers (1 paper)

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Review

33 pages, 1782 KiB  
Review
Cancer Patient-Derived Cell-Based Models: Applications and Challenges in Functional Precision Medicine
by Jelena Dinić, Sofija Jovanović Stojanov, Miodrag Dragoj, Marija Grozdanić, Ana Podolski-Renić and Milica Pešić
Life 2024, 14(9), 1142; https://doi.org/10.3390/life14091142 - 10 Sep 2024
Viewed by 791
Abstract
The field of oncology has witnessed remarkable progress in personalized cancer therapy. Functional precision medicine has emerged as a promising avenue for achieving superior treatment outcomes by integrating omics profiling and sensitivity testing of patient-derived cancer cells. This review paper provides an in-depth [...] Read more.
The field of oncology has witnessed remarkable progress in personalized cancer therapy. Functional precision medicine has emerged as a promising avenue for achieving superior treatment outcomes by integrating omics profiling and sensitivity testing of patient-derived cancer cells. This review paper provides an in-depth analysis of the evolution of cancer-directed drugs, resistance mechanisms, and the role of functional precision medicine platforms in revolutionizing individualized treatment strategies. Using two-dimensional (2D) and three-dimensional (3D) cell cultures, patient-derived xenograft (PDX) models, and advanced functional assays has significantly improved our understanding of tumor behavior and drug response. This progress will lead to identifying more effective treatments for more patients. Considering the limited eligibility of patients based on a genome-targeted approach for receiving targeted therapy, functional precision medicine provides unprecedented opportunities for customizing medical interventions according to individual patient traits and individual drug responses. This review delineates the current landscape, explores limitations, and presents future perspectives to inspire ongoing advancements in functional precision medicine for personalized cancer therapy. Full article
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