Unraveling and Discovering Novel Pathways Regulating Uterine Function and Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1930

Special Issue Editor


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Guest Editor
Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 7C6, Canada
Interests: uterine physiology; endometritis; endometrial inflammation; uterine development; cell signaling; pathways; hippo signaling

Special Issue Information

Dear Colleagues,

Although the ovary has always been considered the commanding officer of reproductive physiology through the regulation of numerous hormones, one should not forget the major contribution of the uterus, the bearer of life. Throughout the estrous cycle and gestation, the uterus can adapt to numerous signals and undergo morphologic changes in an intricate and timed manner. Yet, many alterations or diseases affecting the uterus can have substantial impacts on the reproductive efficiency of humans and animals. Through this Special Issue, we wish to highlight and renew the importance of the uterus by understanding the numerous signaling pathways and factors that can influence uterine physiology and its response to diseases. We therefore invite you to submit your original manuscripts that study the uterus in any species and cover a large range of subjects, including normal uterine physiology, the mechanisms of uterine adaptation to hormones and gestation, pathogenesis of different uterine diseases, novel therapeutic avenues for uterine diseases, the use of animal models for human uterine diseases, etc.

Dr. Guillaume St-Jean
Guest Editor

Manuscript Submission Information

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Keywords

  • uterus
  • uterine function
  • endometrial diseases
  • uterine cancers
  • signaling pathways
  • molecular biology
  • animal models

Published Papers (1 paper)

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Review

17 pages, 3758 KiB  
Review
Uncommon Morphologic Types of Endometrial Cancer and Their Mimickers: How Much Does Molecular Classification Improve the Practice for Challenging Cases?
by Ozlen Saglam
Life 2024, 14(3), 387; https://doi.org/10.3390/life14030387 - 14 Mar 2024
Viewed by 1660
Abstract
The previous endometrial cancer (EC) FIGO staging primarily relied on the extent of the disease spread into the anatomical sites at diagnosis. The most recent one (2023) incorporates clinicopathological features such as histological subtype, tumor grade, the extent of lymphovascular space invasion (LVI), [...] Read more.
The previous endometrial cancer (EC) FIGO staging primarily relied on the extent of the disease spread into the anatomical sites at diagnosis. The most recent one (2023) incorporates clinicopathological features such as histological subtype, tumor grade, the extent of lymphovascular space invasion (LVI), and, when available, molecular subtypes of EC. The emphasis on accurate histological typing, tumor grading, and the molecular features of the cancer is stronger than ever. This review addresses challenging diagnostic patterns in the histologic subtyping and grading EC under five categories: 1. EC with spindle cells, 2. EC with clear cells, 3. EC with a papillary architecture, 4. EC with a biphasic morphology, and 5. EC with a microglandular architecture. The morphological features differentiating low- and high-grade cancers are discussed, along with relevant clinical work-ups. Recent molecular genetic findings regarding the diagnosis and prognosis of the disease and the results of related clinical trials are summarized. The potential challenges in the evaluation of LVI follow these sections. The final section of the review includes an overview of the literature on incorporating molecular subtypes of EC into clinical practice. Full article
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