Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.3
3.2
Journals
Life
Special Issues
Modern Pharmacology and the Role of Natural Products and Leads...
share announcement

Modern Pharmacology and the Role of Natural Products and Leads in Ethnomedicine

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 8329

Special Issue Editor

Dr. Arjun Singh

E-Mail Website
Guest Editor
Molecular Pharmacology Program, Laboratory of Signal Transduction, Mortimer B. Zuckerman Research Center, 417 East 68th Street, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Interests: molecular pharmacology; cancer pharmacology; natural products; ethnomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We wish to concentrate on current developments, novel therapeutic techniques, and the ethnomedicinal significance of natural products, natural compounds, and their novel derivatives in our Special Issue on modern pharmacology. All of these actions point to a significant issue in human sickness and health. We need to identify the target pharmaceuticals so they can only be utilized for use in very good herbal remedies and for their pharmacological benefits, as the expense of healthcare continues to be a significant concern and a financial burden on low-income families. According to the WHO, most pharmaceuticals are available on the market but are very expensive and out of the reach of all patients. The number of these fatalities is increasing daily. Moreover, the prevalence of infections and diseases that are resistant to drugs is rising.

The WHO produced a report in 2019 to prevent a potentially catastrophic drug-resistance catastrophe; they forecast that, by 2050, drug-resistant infections will be responsible for around 10 million annual deaths, and that by 2030, drug resistance will lead to 24 million people into extreme poverty. Lastly, according to the WHO, cancer is the largest cause of mortality across the globe (in 2020 caused about 10 million deaths worldwide). Breast, lung, colon and rectum, prostate, skin, and stomach cancers were the most prevalent in 2020.

Thus, pharmacological repositioning or repurposing as well as natural leads and their derivatives can be used to discover novel and more effective treatments for the aforementioned disorders. Natural leads and their derivatives are examples of natural products that have anti-inflammatory, anti-bacterial, anti-fungal, anti-cancer, neuroprotective, cardioprotective, chemo-preventative, antimicrobial, and antimalarial properties.

Dr. Arjun Singh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • modern pharmacology
  • natural products
  • natural compounds
  • ethnomedicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 2104 KiB  
Article
Selection of a Digitalis purpurea Cell Line with Improved Bioconversion Capacity of Hydroquinone into Arbutin
by Carmen Elena Pop, Ana Coste, Ana-Maria Vlase, Constantin Deliu, Mircea Tămaș, Tibor Casian and Laurian Vlase
Life 2024, 14(1), 84; https://doi.org/10.3390/life14010084 - 4 Jan 2024
Cited by 1 | Viewed by 1308
Abstract
This study aimed to investigate the biotransformation capabilities of a hydroquinone-tolerant Digitalis purpurea cell line (DpHQ) for bioconverting hydroquinone (HQ) into arbutin, a compound with significant therapeutic and cosmetic applications. The research evaluated the influence of various HQ concentrations, feeding protocols, and carbon [...] Read more.
This study aimed to investigate the biotransformation capabilities of a hydroquinone-tolerant Digitalis purpurea cell line (DpHQ) for bioconverting hydroquinone (HQ) into arbutin, a compound with significant therapeutic and cosmetic applications. The research evaluated the influence of various HQ concentrations, feeding protocols, and carbon sources on arbutin bioconversion yield. By using HPLC-MS for the quantification of arbutin in biomass and medium, the study revealed that higher precursor (HQ) concentration led to a more pronounced growth inhibition under single dosing than sequential dosing. At lower sugar (3%) and precursor (4 mM HQ) levels, arbutin predominantly remained within the cells, whereas higher sugar (6%) and HQ (5–6 mM) levels promoted its release into the medium. Arbutin production ranged from 591 mg/L under single dosing to 3049 mg/L with sequential dosing, with the highest yield being achieved with 5 mM HQ in divided doses and 6% glucose. This study holds novelty for being the first to demonstrate the DpHQ’s tolerance to high concentrations of HQ and its efficient capabilities to bioconvert HQ to arbutin, indicating that D. purpurea is equipped with the enzymes required for this process. These aspects highlight its potential as a biotechnological source for arbutin synthesis. Full article
(This article belongs to the Special Issue Modern Pharmacology and the Role of Natural Products and Leads in Ethnomedicine)
►▼ Show Figures

Figure 1

14 pages, 3023 KiB  
Article
Hypolipidemic and Antihyperlipidemic Effects of Holarrhena pubescens Methanolic Extract Is Mediated through Inhibition of Lipase Activity and Lipid Accumulation
by AbdulRahman A. I. Alyahya, Mohammed Asad, Mohammed Alrouji, Kamal Eldin Ahmed Abdelsalam, Adel Mashan Rashed Al-Mutairi and Monjid Ahmed Ibrahim Ahmed
Life 2023, 13(7), 1435; https://doi.org/10.3390/life13071435 - 24 Jun 2023
Viewed by 2315
Abstract
Holarrhena pubescens seeds are used in the treatment of various diseases, especially diabetes and associated complications, in different parts of the world. The present study was undertaken to determine the hypolipidemic and antihyperlipidemic effects of methanolic extract of H. pubescens seeds in rats. [...] Read more.
Holarrhena pubescens seeds are used in the treatment of various diseases, especially diabetes and associated complications, in different parts of the world. The present study was undertaken to determine the hypolipidemic and antihyperlipidemic effects of methanolic extract of H. pubescens seeds in rats. The extract was subjected to LC-MS analysis to determine the chemical constituents. The hypolipidemic action was studied by determining the effect of 28-day oral administration of seed extract on serum cholesterol, serum triglycerides, and serum HDL-cholesterol levels. The antihyperlipidemic action was studied in rats fed with a high-fat diet containing cholesterol and saturated fat, and the same lipid parameters were estimated during 28-day treatment. To elucidate its probable mechanism of action, in vitro studies on the inhibition of lipid accumulation in preadipocytes, DPP-IV inhibitory effect, and lipase enzyme inhibition were studied. The seed extract reduced serum levels of cholesterol and triglycerides in both normal rats and animals fed with a high-fat diet without a significant effect on HDL-cholesterol levels. The seed extract was highly effective in inhibiting lipase enzyme activity but showed a modest effect on the inhibition of lipid accumulation and DPP-IV. The results demonstrated that H. pubescens seed extract has hypolipidemic and antihyperlipidemic effects mediated probably through inhibition of lipase enzyme activity. Full article
(This article belongs to the Special Issue Modern Pharmacology and the Role of Natural Products and Leads in Ethnomedicine)
►▼ Show Figures

Figure 1

27 pages, 1783 KiB  
Article
Phytochemical Profile, Antioxidant, Antimicrobial, and Antidiabetic Activities of Ajuga iva (L.)
by Soukaina Saidi, Firdaous Remok, Nadia Handaq, Aziz Drioiche, Aman Allah Gourich, Naoual El Menyiy, Smail Amalich, Mohamed Elouardi, Hanane Touijer, Mohamed Bouhrim, Latifa Bouissane, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Mohammed Bourhia and Touriya Zair
Life 2023, 13(5), 1165; https://doi.org/10.3390/life13051165 - 11 May 2023
Cited by 9 | Viewed by 3793
Abstract
In Morocco, many applications in ethnomedicine on Ajuga iva (L.) have been recognized as able to treat various pathologies such as diabetes, stress, and microbial infections. The objective of this work is to carry out phytochemical, biological, and pharmacological investigations on the extracts [...] Read more.
In Morocco, many applications in ethnomedicine on Ajuga iva (L.) have been recognized as able to treat various pathologies such as diabetes, stress, and microbial infections. The objective of this work is to carry out phytochemical, biological, and pharmacological investigations on the extracts of Ajuga iva leaves in order to confirm its therapeutic effects. The phytochemical screening carried out on the different extracts of Ajuga iva showed its richness in primary (lipids and proteins) and secondary metabolites (flavonoids, tannins, reducing compounds, oses, and holoside. The best contents of polyphenols, flavonoids, and tannins evaluated by spectrophotometric methods were found in the hydroethanolic extract (69.850 ± 2.783 mg EAG/g DE, 17.127 ± 0.474 mg EQ/g DE, 5.566 ± 0.000 mg EQC/g DE), respectively. Analysis of the chemical composition of the aqueous extract by LC/UV/MS revealed 32 polyphenolic compounds including ferulic acid (19.06%), quercetin (10.19%), coumaric acid (9.63%), and apigenin-7-(2-O-apiosylglucoside) (6.8%). The antioxidant activity of Ajuga iva extracts was evaluated by three methods (DPPH*, FRAP, CAT). The hydroethanolic extract recorded the strongest reducing power: DPPH* (IC50 = 59.92 ± 0.7 µg/mL), FRAP (EC50 = 196.85 ± 1.54 (µg/mL), and CAT (199.21 ± 0.37 mg EAG/gE). A strong correlation between phenolic compounds and antioxidant activities was confirmed by the determination of Pearson’s coefficient. The antimicrobial activity of Ajuga iva studied by the microtiter method revealed potent antifungal and antibacterial qualities against Candida parapsilosis and Staphylococcus aureus BLACT. An in vivo oral glucose tolerance test (OGTT) using normal rats revealed that the antihyperglycemic action of the aqueous extract significantly reduced postprandial hyperglycaemia at (30 min, p < 0.01) and area under the curve (AUC glucose), p < 0.01. Similarly, the aqueous extract, tested on pancreatic α-amylase enzyme activity in vitro and in vivo significantly inhibited pancreatic α-amylase activity with IC50 = 1.52 ± 0.03 mg/mL. In conclusion, the extract from Ajuga iva could be a good source of bioactive molecules, which exhibit potent antioxidant and antimicrobial activity, as well as strong antidiabetic activity, for applications in the pharmaceutical industry. Full article
(This article belongs to the Special Issue Modern Pharmacology and the Role of Natural Products and Leads in Ethnomedicine)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop