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Life
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Immunomodulatory Effects of Adipose-Derived Stem Cells
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Immunomodulatory Effects of Adipose-Derived Stem Cells

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2804

Special Issue Editors

Dr. Anna Barbara Di Stefano

E-Mail Website
Guest Editor
BIOPLAST-Laboratory of BIOlogy and Regenerative Medicine-PLASTic Surgery, Plastic and Reconstructive Surgery Unit, Department of Surgical, Oncological and Oral Sciences, University of Palermo, 90127 Palermo, Italy
Interests: stem cells; cell biology; molecular investigations; bioengineering of cells; tissues; organs; regenerative medicine
Dr. Serena Meraviglia

E-Mail Website
Guest Editor
Department of Biomedicine, Neurosciences and Advanced Diagnosis, University of Palermo, 90133 Palermo, Italy
Interests: cell biology; molecular investigations; immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Adipose-derived stem cells (ASCs), abundant in the human body, could be harvested with minimal invasiveness and are becoming increasingly widespread in treating various diseases. The regenerative properties of these cells are widely known. The aim of this Special Issue is to evaluate, in particular, the immunomodulatory effects of adipose stem cells. Thus, this Special Issue welcomes full papers and review articles on the 'immuno-privileged' properties of ASCs.

This Special Issue will serve as a reference text for researchers and academics, as well as those studying the ASCs properties and their potential clinical uses. Researchers working in the field of regenerative medicine and immunological related pathways are encouraged to publish their recent findings in this Special Issue of Life.

Dr. Anna Barbara Di Stefano
Dr. Serena Meraviglia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adipose stem cells
  • immunological activities
  • regenerative medicine
  • stemness
  • differentiative potential
  • plastic and reconstructive surgery
  • pre-clinical and clinical applications

Published Papers (1 paper)

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Research

14 pages, 1841 KiB  
Article
Suppression of Lipid Accumulation in the Differentiation of 3T3-L1 Preadipocytes and Human Adipose Stem Cells into Adipocytes by TAK-715, a Specific Inhibitor of p38 MAPK
by Nivethasri Lakshmana Perumal, Amila Mufida, Anil Kumar Yadav, Dae-Gu Son, Young-Wook Ryoo, Sung-Ae Kim and Byeong-Churl Jang
Life 2023, 13(2), 412; https://doi.org/10.3390/life13020412 - 1 Feb 2023
Cited by 1 | Viewed by 2505
Abstract
Excessive preadipocyte differentiation is linked with obesity. Although previous studies have shown that p38 MAPK is associated with adipogenesis, the regulation of preadipocyte differentiation by TAK-715, an inhibitor of p38 mitogen-activated protein kinase (MAPK), remains unclear. Interestingly, TAK-715 at 10 μM vastly suppressed [...] Read more.
Excessive preadipocyte differentiation is linked with obesity. Although previous studies have shown that p38 MAPK is associated with adipogenesis, the regulation of preadipocyte differentiation by TAK-715, an inhibitor of p38 mitogen-activated protein kinase (MAPK), remains unclear. Interestingly, TAK-715 at 10 μM vastly suppressed the accumulation of lipid and intracellular triglyceride (TG) content with no cytotoxicity during 3T3-L1 preadipocyte differentiation. On mechanistic levels, TAK-715 significantly decreased the expressions of the CCAAT/enhancer-binding protein-α (C/EBP-α), peroxisome proliferator-activated receptor gamma (PPAR-γ), fatty acid synthase (FAS), and perilipin A. Similarly, the phosphorylation of the signal transducer and activator of transcription-3 (STAT-3) in differentiating 3T3-L1 cells was also reduced with TAK-715 treatment. Moreover, TAK-715 significantly blocked the phosphorylation of activating transcription factor-2 (ATF-2), a p38 MAPK downstream molecule, during 3T3-L1 preadipocyte differentiation. Of importance, TAK-715 also markedly impeded the phosphorylation of p38 MAPK and suppressed lipid accumulation during the adipocyte differentiation of human adipose stem cells (hASCs). Concisely, this is the first report that TAK-715 (10 μM) has potent anti-adipogenic effects on the adipogenesis process of 3T3-L1 cells and hASCs through the regulation of the expression and phosphorylation of p38 MAPK, C/EBP-α, PPAR-γ, STAT-3, FAS, and perilipin A. Full article
(This article belongs to the Special Issue Immunomodulatory Effects of Adipose-Derived Stem Cells)
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