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Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third...
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Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 2574

Special Issue Editor

Prof. Dr. Alin Laurentiu Tatu

E-Mail Website
Guest Editor
1. Clinical Department, Dermatology, Faculty of Medicine and Pharmacy, Dunarea de Jos University, Galati, Romania
2. Dermatology Department, Saint Parascheva Clinical Hospital of Infectious Diseases, Galati, Romania
3. Multidisciplinary Integrative Center for Dermatologic Interface Research MIC-DIR, Galati, Romania
Interests: Demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy; cutaneous comorbidities; skin cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Considering recent advances in the field, dermatovenerology has proven to be a specialty of clinical, investigative and therapeutic interest. Medical history and clinical examination, followed by non-invasive imaging, blood tests or the exploration of skin structures and their pathological changes, allow pathologists to better understand, detect and define diseases of the skin. Cutaneous signs and symptoms thus represent a window into the systemic state of the human body. Many diseases thought to be localized to the skin are now considered to be systemically involved in other areas. Each patient is unique, with their own comorbidities and anatomic or physiologic particularities.

Cutaneous skin diseases vary in appearance, evolution and prognosis, as well as in their response to various treatments. The management of skin disease comorbidities requires interdisciplinary collaboration among medical and surgical specialties. Novel treatments are now available for various skin conditions, including surgical, cosmetic and physiotherapeutic procedures. Drugs of both plant and chemical origin can produce systemic or adverse skin reactions. If classical therapy is ineffective or is not tolerated, off-the-label drugs or complementary and alternative medicine methods can be used as part of an integrative medicine treatment.

The new perspectives offered by translational medicine and research on the microbiome, endosymbionts, inflammatory molecules, diagnostics, treatments and observations of comorbidities, complications and their management are improving the standard of skin care, placing it in the context of personalized medicine and care.

This Special Issue of Life will collect and present data on the latest developments in the field. We welcome reviews and research/original articles. Life has no restrictions on the maximum length of research manuscripts, provided that the text is concise and comprehensive. Papers may have two corresponding authors and two first authors at most.

Given that the first and second edition of this Special Issue were a great success, we now invite you to publish in the third edition (https://www.mdpi.com/journal/life/special_issues/Dermatology_research; https://www.mdpi.com/journal/life/special_issues/U96NJI7EDI).

Prof. Dr. Alin Laurentiu Tatu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Demodex
  • endosymbionts
  • cutaneous microbiome
  • integrative medicine
  • optical coherence tomography
  • dermoscopy
  • confocal microscopy
  • cutaneous comorbidities keyword
  • inflammatory diseases
  • hair
  • skin cancer
  • comorbidities
  • skin surgery

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

12 pages, 523 KB  
Article
Comparative Effectiveness and Safety of Fractional Laser and Fractional Radiofrequency for Atrophic Acne Scars: A Retrospective Propensity Score Analysis
by Chadakan Yan, Phichayut Phinyo, Yuri Yogya, Mati Chuamanochan and Rungsima Wanitphakdeedecha
Life 2025, 15(9), 1379; https://doi.org/10.3390/life15091379 - 1 Sep 2025
Viewed by 298
Abstract
Fractional laser (FL) and fractional radiofrequency (FRF) are effective treatments for atrophic acne scars, yet comparative data in Asian populations with darker skin types remain limited. This retrospective cohort study compared the clinical effectiveness and safety of FL and FRF in Thai patients [...] Read more.
Fractional laser (FL) and fractional radiofrequency (FRF) are effective treatments for atrophic acne scars, yet comparative data in Asian populations with darker skin types remain limited. This retrospective cohort study compared the clinical effectiveness and safety of FL and FRF in Thai patients aged 18–60 years with Fitzpatrick skin types III–IV who underwent at least two treatment sessions between 2012 and 2023. Baseline characteristics were balanced using propensity score stratification, and missing data were addressed through multiple imputation with chained equations. The primary endpoint was the proportion of patients achieving ≥25% improvement in scarring at 6 months, with equivalence testing performed using a 20% margin. A total of 397 patients (254 FL, 143 FRF) were included, with balanced baseline characteristics after stratification. At 6 months, 88.1% of FRF-treated and 71.9% of FL-treated patients achieved the primary endpoint. FRF showed numerically greater mean improvement at all time points, though differences were not statistically significant. FL met the non-inferiority criterion but not equivalence. FRF was associated with significantly higher pain scores (p < 0.001), while adverse events, including post-inflammatory hyperpigmentation, were rare and similar between groups. Both modalities demonstrated meaningful clinical benefit and acceptable safety, although statistical equivalence could not be established and FRF was associated with greater procedural discomfort. Full article
(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition)
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16 pages, 1003 KB  
Article
MMP-2—Potential Predictor of Epithelial–Mesenchymal Transition in Squamous Cell Carcinogenesis
by Doinița Temelie-Olinici, Bild Walther, Laura Gheucă-Solovăstru, Mihaela Perțea, Daniela-Anicuța Leca, Bogdan-Vasile Grecu, Ioana-Alina Halip, Mădălina Mocanu, Ioana-Adriana Popescu, Adriana-Ionela Pătrașcu and Dan Vâță
Life 2025, 15(7), 1060; https://doi.org/10.3390/life15071060 - 2 Jul 2025
Viewed by 496
Abstract
Epithelial–mesenchymal transition (EMT) is one of the key steps in cutaneous carcinogenesis. At the molecular level, this cellular dedifferentiation is modulated by the interaction of signalling pathways that favour basement membrane degradation under the influence of proinflammatory cytokines and matrix metalloproteinases (MMPs). Given [...] Read more.
Epithelial–mesenchymal transition (EMT) is one of the key steps in cutaneous carcinogenesis. At the molecular level, this cellular dedifferentiation is modulated by the interaction of signalling pathways that favour basement membrane degradation under the influence of proinflammatory cytokines and matrix metalloproteinases (MMPs). Given the intricate role of these endopeptidases in modulating extracellular matrix turnover, the present study aimed primarily to identify the MMP-2 expression profile during the early stages of cutaneous malignant transformation. Forty-eight lesions with malignant transformation potential were excised in healthy tissue. Following the histopathological diagnosis of keratoacanthoma, Bowen’s disease and actinic keratosis, the biological preparations were deparaffinised and homogenised in order to perform the FRET technique using the “MMP-2 Assay Kit Fluorometric”. The results of the previous part of this research indicate that MMP-2 expression is more intense in lesions of actinic keratosis compared to normal tissues and to keratoacanthoma or Bowen’s disease lesions, inversely proportional to the histopathological degree of dysplasia. Monitoring metalloproteinase activity in dysplastic epithelium may improve the detection of malignant transformation and guide treatment decisions. Full article
(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition)
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18 pages, 821 KB  
Article
Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging
by Florin Ciprian Bujoreanu, Diana Sabina Radaschin, Mihail Alexandru Badea, Laura Bujoreanu Bezman, Carmen Pantiș, Carmen Tiutiuca, Liliana Baroiu, Elena Niculeț, Alina Pleșea Condratovici and Alin Laurențiu Tatu
Life 2025, 15(3), 485; https://doi.org/10.3390/life15030485 - 17 Mar 2025
Viewed by 1312
Abstract
Psoriasis is one of the most frequent immune-mediated chronic inflammatory cutaneous disease that exerts a considerable psychological impact, including low self-esteem, stigmatization, and depression. In recent years, biologic therapies have substantially transformed the therapeutic landscape for individuals with moderate-to-severe psoriasis, shifting treatment towards [...] Read more.
Psoriasis is one of the most frequent immune-mediated chronic inflammatory cutaneous disease that exerts a considerable psychological impact, including low self-esteem, stigmatization, and depression. In recent years, biologic therapies have substantially transformed the therapeutic landscape for individuals with moderate-to-severe psoriasis, shifting treatment towards a more targeted and personalized approach. Seborrheic keratoses (SKs) are common benign skin lesions, and their association with psoriasis and biologic therapy remains poorly understood. Our retrospective study evaluated a small cohort of patients with moderate-to-severe psoriasis undergoing biologic therapy at a tertiary dermatology center in Southeastern Europe to evaluate potential correlations with SK development. Smokers had fewer SKs, whereas postmenopausal women and osteoporosis patients had significantly higher SK counts, implicating hormonal influences. PUVA therapy was linked to an increased SK count, whereas UVB and methotrexate treatments had a lesser effect. These findings suggest that biologic therapy and systemic factors may influence SK development, emphasizing the need for further prospective research. Full article
(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy—Third Edition)
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