Life, Volume 15, Issue 10

Background: Primary headaches in children and adolescents impose emotional, cognitive, and functional burdens beyond pain. This review synthesizes their psychopathological and neuropsychological dimensions and outlines implications for assessment and...

Background: Postoperative delirium is frequent among elderly patients and often presents after major surgery or intervention. Validated screening tools should be routinely used to recognise this psychopathological syndrome. Delirium might be associat...

Introduction/Background: Most adrenal incidentalomas (AIs) are non-functioning adrenal tumors (NFATs) without clinically overt hormonal hypersecretion; one-third show subtle endocrine over-activity and mild autonomous cortisol secretion (MACS). One o...

Highly degraded sterols belonging to the incisterol group have been identified in a large set of microorganisms. The leading product in the family is demethylincisterol A3 (DM-A3), isolated from various fungi and endowed with marked antitumor propert...

(1) Background: Individuals affected by schizophrenia spectrum disorders (SSDs) have an increased risk for cardiometabolic diseases. Improved cardiorespiratory fitness (CRF) is associated with lower cardiometabolic risk. The aim of the study was to a...

Background: β-casomorphin-10 (CM-10), a peptide fragment derived from milk casein with the sequence YPFPGPIPNS, has demonstrated notable anxiolytic activity in BALB/c mice. Yet, its cellular responses and mechanistic pathways remain largely unch...

Kidney transplant recipients remain at high risk of cardiovascular events and premature death. Whether chronic histological changes in protocol allograft biopsies provide prognostic information for patient outcomes beyond graft survival remains uncer...

Breast cancer remains a leading cause of morbidity and mortality in women worldwide. Despite significant advances in targeted therapies, therapeutic resistance, metabolic toxicities, and disease recurrence continue to limit long-term efficacy. Metabo...

New brain imaging modalities and neuropsychological testing tools are used to study neuronal changes in brain injuries such as mild traumatic brain injury (mTBI). Here we utilized diffusion tensor imaging (DTI) parameters and Wisconsin Card Sorting T...

Exercise training is a versatile and powerful tool to improve muscle function [...]

The aim of this retrospective clinical pilot study is to evaluate multiparametric ultrasound liver parenchyma assessments in the diagnosis of Osler’s disease, and to detect micro-shunts using SRCEUS with quantifications at the capillary level....

Stuttering, a complex and multifactorial speech disorder, has long presented an enigma regarding its etiology. While earlier approaches often emphasized psychosocial influences, historical clinical and speech-language strategies have considered multi...

This study investigates the relationship between biosecurity implementation and the prevalence of ESBL-producing bacteria in Greek swine farms, revealing an alarming 82% prevalence rate, which is significantly higher than in other European nations. O...

Early intervention is pivotal for optimizing neurodevelopmental outcomes in children with language delay, where increased language stimulation can optimize therapeutic outcomes. Extending speech–language therapy from clinical settings to the ho...

A better understanding of diabetic kidney disease (DKD) will help optimize its management. Few animal models replicate human DKD characteristics as closely as ZSF1 male rats. To address the male-specific focus in murine model systems, we aimed to cha...

Background: Variceal upper gastrointestinal bleeding (VUGIB) remains a major cause of short-term mortality in cirrhosis despite advances in endoscopic and pharmacological therapy. Prognostic factors and outcomes were evaluated in a historical cohort,...

The highly pathogenic avian influenza (HPAI) H5N1 virus poses a growing global health threat, particularly following its unprecedented spillover into dairy cattle and subsequent transmission to more than 1000 dairy farms in 18 states. This study inve...

Pectus excavatum (PE) is the most common deformity of the chest wall seen in children and adolescents. Besides its visible depression of the chest, this condition often causes functional impairments affecting the cardiovascular and respiratory system...

Fencing demands a unique blend of endurance, explosive power, and asymmetric neuromuscular control. This study compared physiological profiles of elite (top 25 nationally ranked, n = 16) and non-elite (positions 26–102, n = 33) Polish male fenc...

Cutaneous aging is associated with oxidative stress and visible changes on the skin, such as uneven pigmentation, wrinkles, and loss of radiance. Glutathione (GSH), an endogenous antioxidant with anti-melanogenic properties, is considered a promising...

Hemodynamic monitoring is essential in the postoperative management of neonates undergoing cardiac surgery, enabling early identification of circulatory failure and its underlying cause, optimization of oxygen delivery to tissues, and evaluation of t...

Pediatric brain arteriovenous malformations (AVMs) are rare but high-risk vascular anomalies associated with substantial morbidity and mortality due to their elevated lifetime risk of rupture. Over the past decade, advances in microsurgical resection...

Visual skills are increasingly recognized as critical to athletic performance, yet it remains unclear whether participation in specific team sports is associated with enhanced visual function. This cross-sectional study compared visual acuity, periph...

Bast fibrous plants are recognized as potential sources of pectin, yet the structural characteristics and functional properties of pectic polysaccharides derived from these plants remain insufficiently investigated. In this study, three pectic polysa...

Meeting the growing demand for vegetable oil while promoting agricultural sustainability in Northeast China requires developing high-yield, high-oil-content soybean varieties. We present the comprehensive development and evaluation of Heinong 551, an...

Background: Massive intraoperative blood loss (IBL) is a serious complication in complex spine surgeries such as deformity correction, multilevel fusion, tumor resection, and revision procedures. While no strict definition exists, blood loss exceedin...

Prompt reversal of anticoagulation in the elderly population with subdural hematoma (SDH) is critical to reduce morbidity and facilitate timely surgical intervention. In patients receiving dabigatran, idarucizumab provides rapid anticoagulation rever...

We developed a model that classifies normal and abnormal brain MRI images. This study initially referenced a small-scale real patient dataset (98 normal and 155 abnormal MRI images) provided by the National Institute of Aging (NIA) to illustrate the...

Background: This study aimed to evaluate the effects of Trimix^® on the microvilli and glycocalyx of ocular conjunctival epithelial cells, assessing drug persistence on the cell surface and its interaction with the glycocalyx. Microvilli, vital in...

Heart failure remains a significant global health concern, profoundly impacting the lives of millions and placing considerable strain on healthcare systems worldwide [...]

Dirofilariosis, a parasitic disease caused by nematodes of the genus Dirofilaria, primarily affects dogs but can also infect other carnivores and, more rarely, humans. In Europe, the most commonly involved species are D. immitis and D. repens, transm...

Cell-based therapeutics are redefining interventions for vision loss by enabling tissue replacement, regeneration, and neuroprotection. This review surveys contemporary cellular strategies in ophthalmology through the lenses of therapeutic effectiven...

Managing women with diminished ovarian reserve for in vitro fertilization (IVF) is challenging, often resulting in low oocyte yield and cycle failures. We hypothesize that coupling in vitro fertilization (IVF) with rescue in vitro maturation (r-IVM)...

Background: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by progressive fibrosis, systemic inflammation and vascular dysfunction, with manifestations that can affect multiple organs, including the heart. Cardiac involvement in...

In the original publication [...]

HP, as an isotropic physical stress, has been widely applied in cell biology and reproductive research to simulate the effects of environmental pressure on cellular functions. In this study, the elastic silicone membrane of a novel bionic inseminatio...

Brown algae (Phaeophyceae) play vital ecological roles in marine ecosystems and are important models for studying organelle genome evolution. Despite their significance, mitogenome data for many taxa remain limited. In this study, we present the comp...

Preterm prelabor rupture of membranes (PPROM) is a leading cause of preterm birth and significant neonatal morbidity. The vaginal microbiome is implicated in its pathogenesis, but its detailed characteristics and functional consequences remain to be...

Background: MicroRNA-129 (miR-129) is a tumor suppressor involved in regulating oncogenic pathways, but its role in gastric adenocarcinoma and its potential connections to vascular and neurological dysfunction remain insufficiently defined. Objective...

Chronic insomnia is a prevalent and disabling sleep disorder with growing evidence linking it to cardiovascular and cerebrovascular morbidity. Stroke, a leading cause of mortality and a long-term disability worldwide, may be influenced by sleep distu...

Background: Serous papillary adenofibroma cyst (SPAC) of the ovary is a rare benign epithelial tumor that can mimic borderline or malignant ovarian neoplasms. Reports in young women are particularly scarce. Purpose: The aim of this study is to presen...

Highly selective inhibitors of the members of the cAMP-selective cyclic nucleotide phosphodiesterases, or PDE4 family, have shown clinically meaningful activity in two different classes of lung disease: roflumilast in obstructive lung disease, specif...

Diffusion basis spectrum imaging–derived restricted fraction (DBSI-RF) isolates the low apparent diffusion coefficient water signal attributed to cellular crowding. It is therefore proposed as a putative magnetic resonance imaging (MRI) marker...

Antibiotics are essential for treating bacterial and fungal infections in plants, animals, and humans. Their widespread use in agriculture and the food industry has significantly enhanced animal health and productivity. However, extensive and often i...

Dietary fiber plays an important role in animal nutrition by influencing gut health, feed intake, and metabolism. In swine production, studies suggest that fibers may also affect reproductive traits, but findings remain inconsistent, especially in ad...

Objectives: This study evaluated the utility of complex morphometric analyses for predicting radiation pneumonitis (RP) and proposed a quantitative prognostic framework for patients with non-small cell lung cancer (NSCLC) undergoing curative-intent r...

Rice (Oryza sativa L.) is a salt-sensitive crop, where even moderate soil salinity (electrical conductivity ≥ 3.5 dS/m) can cause significant yield reduction. During the seedling stage, the underdeveloped root system has limited capacity for salt...

Background: Diabetes mellitus is a well-established risk factor for surgical site infections (SSIs), particularly periprosthetic joint infections (PJIs) following joint arthroplasty. Although strict glycemic control in the early postoperative period...

Platelets play a pivotal role in coagulation, traditionally recognized for their involvement in thrombin generation via the prothrombinase complex and for regulating thrombopoietin (TPO) synthesis through platelet-mediated TPO uptake. However, recent...

Background/Objective: The recurrence of hallux valgus (HV) after primary surgical correction remains a clinical challenge, often requiring combined approaches to address both bony realignment and soft tissue imbalance. While locking plates have shown...